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Application of lactobacillus paracasei N1115 in preventing colonitis, corresponding probiotic powder and application

A technology of probiotics and lactobacilli, applied in the field of bioengineering, can solve problems such as unclear mechanism, no clear and effective methods and means, and poor effect, and achieve the effects of good taste, easy preservation, and prevention of colitis

Inactive Publication Date: 2019-03-19
JUNLEBAO DAIRY GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the mechanism of IBD is not clear, there are no clear and effective methods and means for the prevention of IBD in the prior art. At present, traditional Chinese medicine or combined traditional Chinese and Western medicine are generally used in China, but the effect is not good.

Method used

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  • Application of lactobacillus paracasei N1115 in preventing colonitis, corresponding probiotic powder and application
  • Application of lactobacillus paracasei N1115 in preventing colonitis, corresponding probiotic powder and application
  • Application of lactobacillus paracasei N1115 in preventing colonitis, corresponding probiotic powder and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 The application of Lactobacillus paracasei N1115 to prevent colitis

[0032] In this embodiment, newborn C57BL / 6 mice were used as test subjects. The mice used were 12 female and 12 male mice provided by Vanderbilt University in the United States, with a body weight of 1.5 g, including:

[0033] Step 1. Intervention: 24 newborn C57BL / 6 mice were randomly divided into two groups, with 6 males and 6 males in each group. One group was the Lactobacillus paracasei N1115 intervention group, and the other group was the control group. Among them, the mice in the Lactobacillus paracasei N1115 intervention group were fed with 10 bacteria of Lactobacillus paracasei N1115 every day from the first day after birth to the seventh day after birth. 7 CFU (20μl water contains 10 bacteria 7 CFU); from the 8th day to the 14th day after birth, the mice were fed with 10 bacteria of Lactobacillus paracasei N1115 every day 8 CFU (20μl water contains 10 bacteria 8 CFU). The mice ...

Embodiment 2-7

[0051] Embodiment 2-7 utilizes the probiotic powder prepared by Lactobacillus paracasei N1115

[0052] Examples 2-7 are respectively a kind of probiotic powder prepared by utilizing Lactobacillus paracasei N1115, and they are all uniformly prepared by mixing curcumin, fructooligosaccharides, high-fat cocoa powder and Lactobacillus paracasei. The raw material proportioning of these embodiments sees the following table 1:

[0053] Table 1 Example 2-7 raw material ratio

[0054]

[0055] Embodiment 2-7 utilizes the combination of traditional Chinese medicine curcumin and Lactobacillus paracasei N1115 to better prevent colitis, but due to the low solubility of curcumin, it is necessary to increase the solubility of curcumin during reconciliation to make this embodiment more effective Therefore, the present embodiment has carried out a solubility test for curcumin, and the materials used in the test are: curcumin, common flavoring agents and prebiotics, and the flavoring agents...

Embodiment 8 Embodiment 2-7

[0079] Embodiment 8 The application of probiotic powder provided by embodiment 2-7

[0080] Each of the probiotic powders provided in Examples 2-7 was tested with newborn C57BL / 6 mice, and the mice used were 12 female and 12 male mice provided by Vanderbilt University in the United States. , weighing 1.5g, including:

[0081] Step 1. Intervention: 24 newborn C57BL / 6 mice were randomly divided into two groups, one group was the probiotic powder intervention group, and the other group was the control group. The mice in the intervention group were fed probiotic powder every day from the 1st day to the 7th day after birth (the amount of gavage was based on the number of Lactobacillus paracasei N1115 contained in 10 7 CFU calculation); from the 8th day to the 14th day after birth, the mice were fed with probiotic powder every day (the number of Lactobacillus paracasei N1115 contained in the stomach was taken as 10 8 CFU calculation). The mice in the control group were fed with t...

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Abstract

The invention provides application of lactobacillus paracasei N1115 in preventing colonitis, corresponding probiotic powder and application. The lactobacillus paracasei N1115 is used for early-stage intervention or prevention of colonitis and can effectively prevent colonitis. The probiotic powder prepared by utilizing the lactobacillus paracasei N1115 and capable of preventing colonitis can effectively prevent colonitis and is good in taste and suitable for all people.

Description

technical field [0001] The invention belongs to the field of bioengineering, and relates to an application of preventing colitis strains, specifically an application of Lactobacillus paracasei N1115 for preventing colitis; the invention also provides a preparation of Lactobacillus paracasei N1115 A probiotic powder and its application. Background technique [0002] Inflammatory bowel disease (IBD) is a group of chronic, non-specific intestinal inflammatory diseases of unknown etiology, mainly including ulcerative colitis and Crohn's disease. If the patient suffers from this disease and the symptoms cannot be effectively controlled, inflammation The substance will flow to the whole body with the blood, which may cause systemic immune diseases such as iritis, arthritis, erythema nodosum, etc. Therefore, IBD patients are more likely to suffer from colorectal cancer than ordinary people. [0003] Since the initial symptoms of IBD patients are quite similar to the common stress ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61K9/14A61K47/46A61K47/26A61P1/00A61P29/00A61K31/12C12R1/225
CPCA61K9/145A61K9/148A61K31/12A61K35/747A61P1/00A61P29/00C12N1/20A61K2300/00
Inventor 王世杰张栋朱宏冯丽莉薛玉玲荀一萍杨利刚魏立华
Owner JUNLEBAO DAIRY GRP CO LTD
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