Polyepoxypropylhexylguanidine hydrochloride and preparation method thereof

The technology of polyglycidyl hexylguanidine hydrochloride and guanidine hydrochloride is applied in the field of plastic antibacterial agents, and can solve the problems of delayed effect of silver-based antibacterial agents, easy discoloration of mammalian cytotoxicity, and PET plastic wire drawing process. Can not be carried out, affect the structure and performance of PET, etc., to achieve the effect of excellent sterilization effect, wide application range and low cost

Inactive Publication Date: 2019-03-22
上海高聚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this solution only solves the technical problem of poor compatibility with plastics when the silver-based antibacterial agent is added, and its production process is still costly and cumbersome, and the prepared plastic antibacterial agent does not solve the delayed effect of the silver-based antibacterial agent. Disadvantages such as non-toxicity, easy discoloration, and toxicity to mammalian cells
[0004] As we all know, organic antibacterial agents are generally eluted. After adding plastics, they cannot react with plastics for chemical modification, but only combine them by physical mixing. Therefore, antibacterial agents cannot be tightly combined with plastics and will be destroyed during use. Dissolution of water-based and oil-based solvents will not have a long-lasting antibacterial effect
Moreover, some organic polymer antibacterial agents (such as polyhexylguanidine hydrochloride) are even more problematic. Because the antibacterial agent is simply mixed with plastics, the terminal amino groups in the antibacterial agent molecules will degrade the ester groups in the PET plastic molecules. The effect will not only affect the structure and performance of PET, but also lead to the failure of the drawing process of PET plastics, thus limiting the application range of such antibacterial agents on plastics

Method used

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  • Polyepoxypropylhexylguanidine hydrochloride and preparation method thereof
  • Polyepoxypropylhexylguanidine hydrochloride and preparation method thereof
  • Polyepoxypropylhexylguanidine hydrochloride and preparation method thereof

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Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of polyglycidyl hexylguanidine hydrochloride solid a

[0032] S1: Keep the 500L reactor stirring at a constant speed, add 100.00kg of guanidine hydrochloride, 121.70kg of 1,6-hexamethylenediamine, and 0.30kg of malondialdehyde as an initiator in sequence. Stir the reaction at 5°C for 45 minutes, stir the reaction at 120±5°C for 80 minutes, and stir the reaction at 140±5°C for 90 minutes;

[0033] S2: Maintain the reaction temperature at 140±5°C, and add 60.80 kg of propylene oxide at a constant speed within 15 minutes, and then continue to stir for 20 minutes;

[0034] S3: Add 0.32 kg of stopper propylene glycol into the reactor, stop heating, continue to stir for 10 minutes, and then the reaction ends to obtain a polymer melt;

[0035] S4: Transfer the polymer melt in the reaction kettle to a hydrolysis tank, add 350kg of pure water for hydrolysis, and obtain an aqueous solution of polyglycidyl hexylguanidine hydrochloride crude product w...

Embodiment 2

[0038] Embodiment 2: the preparation of polyglycidyl hexylguanidine hydrochloride solid b

[0039]S1: Keep the 1000L reactor stirring at a constant speed, add 250.00kg of guanidine hydrochloride, 304.10kg of 1,6-hexamethylenediamine, and 0.90kg of the initiator succinic dialdehyde in sequence. Stir the reaction at 5°C for 70 minutes, stir the reaction at 120±5°C for 110 minutes, and stir the reaction at 140±5°C for 120 minutes;

[0040] S2: Maintain the reaction temperature at 140±5°C, and add 152.00 kg of propylene oxide at a constant speed within 25 minutes, and then continue to stir for 30 minutes;

[0041] S3: Add 0.94 kg of stopper butanediol into the reactor, stop heating, continue to stir for 20 minutes, and then the reaction ends to obtain a polymer melt;

[0042] S4: Transfer the polymer melt in the reaction kettle to a hydrolysis tank, add 1500kg of pure water for hydrolysis, and obtain an aqueous solution of polyglycidyl hexylguanidine hydrochloride crude product w...

Embodiment 3

[0044] Embodiment 3: the preparation of test sample

[0045] 1. The preparation of polyglycidyl hexylguanidine hydrochloride 0.5% (w / w) aqueous solution sample: get 5.00g polyglycidyl hexylguanidine hydrochloride solid a, dilute to 0.5% (w / w) with 995.00g pure water / w) aqueous solution, numbered as 1# sample.

[0046] ②Preparation of antibacterial plastic samples with 0.5% (w / w) polyglycidyl hexylguanidine hydrochloride powder added: take 150.0 g of polyglycidyl hexylguanidine hydrochloride solid a, and grind it into powder. Get 30.0g polyglycidyl hexyl guanidine hydrochloride powder, in the blow molding process in plastics production, 30.0g polyglycidyl hexyl guanidine hydrochloride powder is evenly added in the plastics of 5970g, keep temperature at Above 160°C for 10 minutes to make it fully react to produce antibacterial plastics. According to different plastic materials, according to this method, 6000g of antibacterial plastics made of PP, PE, PET, PVC, and PS were res...

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Abstract

The invention belongs to the technical field of plastic antibacterial agents, and particularly relates to polyepoxypropylhexylguanidine hydrochloride and a preparation method thereof. The preparationmethod of the polyepoxypropylhexylguanidine hydrochloride has the advantages that the technology is simple, and the cost is low. The polyepoxypropylhexylguanidine hydrochloride prepared by the preparation method has the advantages that the purity is high, and the yield rate can stably reach 90.0% to 95.0%; the sterilizing effect is excellent, and the poison and irritation are avoided; the polyepoxypropylhexylguanidine hydrochloride can be used as an antibacterial agent to be added into PP (polypropylene), PE (polyethylene), PET (polyethylene terephthalate), PVC (polyvinyl chloride) and other plastics to further prepare the antibacterial plastics, and the influence on the appearance, transparency, plasticity, hardness and other properties of the plastic is avoided; the polyepoxypropylhexylguanidine hydrochloride and the plastic can generate grafting copolymerizing reaction at the temperature of 160 DEG C, and the polyepoxypropylhexylguanidine hydrochloride cannot be dissolved out by thewater-based and oil-based solvents after combining, so that the prepared antibacterial plastic can realize lasting antibacterial characteristic.

Description

technical field [0001] The invention belongs to the technical field of plastic antibacterial agents, in particular to polyglycidyl hexylguanidine hydrochloride and a preparation method thereof. Background technique [0002] With the development of the economy and the improvement of people's health and safety awareness, antibacterial plastics have become a very popular product category and are widely used in industries, agriculture, medical care, daily life and public facilities. However, the various plastic antibacterial agents commonly used at present often cannot meet the actual production and use needs. [0003] Existing plastic antibacterial agents mainly include inorganic silver antibacterial agents and organic antibacterial agents. However, inorganic silver antibacterial agents have many disadvantages, for example: ① due to the rare and expensive silver raw materials, the cost of silver-based antibacterial agents is too high; ② silver ions are harmful to mammalian cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/00C08L23/12C08L23/06C08L67/02C08L27/06C08L25/06C08L79/00
CPCC08G73/00C08L23/06C08L23/12C08L25/06C08L27/06C08L67/02C08L79/00
Inventor 余刚
Owner 上海高聚生物科技有限公司
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