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Drug composition for treating radiation-induced oral mucositis and application thereof

A technology of oral mucositis and composition, which is applied in the field of medicine, can solve the problems such as radioactive oral mucositis has not been reported, and achieve the effects of shortening the symptom relief time, reducing the degree of damage, and good application prospects

Inactive Publication Date: 2019-03-26
JINSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But about a kind of pharmaceutical composition for the treatment of radiation oral mucositis of the present invention and its application, there is no report yet

Method used

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  • Drug composition for treating radiation-induced oral mucositis and application thereof
  • Drug composition for treating radiation-induced oral mucositis and application thereof
  • Drug composition for treating radiation-induced oral mucositis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 pharmaceutical composition (one)

[0030] Take the raw material medicine according to the ratio: add lidocaine hydrochloride injection 0.2g, vitamin B in 250ml of 20% mannitol injection successively 12 Injection 10mg, dexamethasone sodium phosphate for injection 5mg, racemic bepolamine hydrochloride injection 10mg, mix thoroughly and evenly.

Embodiment 2

[0031] Embodiment 2 pharmaceutical composition (two)

[0032] Take the raw material medicine according to the ratio: add lidocaine hydrochloride injection 0.1g, vitamin B in 250ml of 20% mannitol injection successively 12 Injection 15mg, dexamethasone sodium phosphate for injection 2mg, racemic bepolamine hydrochloride injection 15mg, mix thoroughly and evenly.

Embodiment 3

[0033] Embodiment 3 pharmaceutical composition (three)

[0034] Take the raw material medicine according to the ratio: add lidocaine hydrochloride injection 0.3g, vitamin B in 250ml of 20% mannitol injection successively 12 Injection 5mg, dexamethasone sodium phosphate for injection 8mg, racemic bepolamine hydrochloride injection 5mg, mix thoroughly and evenly.

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PUM

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Abstract

The invention relates to a drug composition for treating radiation-induced oral mucositis and application thereof. The drug composition is prepared from the following crude drugs: 20% of mannitol injection, lidocaine hydrochloride injection, vitamin B12 injection, dexamethasone sodium phosphate for injection and raceanisodamine hydrochloride injection. The invention also provides the application of the drug composition in preparation of a drug for treating radiation-induced acute oral mucositis. The drug composition and the application thereof have the advantages that (1) compared with the traditional drug for clinically treating the radiation-induced oral mucositis, the injury degree of the radiation-induced oral mucositis can be obviously relieved, the symptom relieving time can be obviously shortened, and the survival quality in the radiotherapy process of a patient can be improved; (2) the preparation process of a formula is simple, special process and conditions are not needed, the drugs needed by composition of the formula are clinically-common drugs respectively, the drug source is sufficient, the price is low, the preparation is convenient, the storage and transportation are convenient, the economic burden of the patient is low and the drug composition can be well applied on clinic.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating radiation-induced oral mucositis and its application. Background technique [0002] Tumor radiotherapy is often accompanied by damage to normal tissues, including skin damage, mucosal damage, and hair damage, due to the high-energy particles or rays (including high-energy electrons, protons, neutrons, gamma rays, X-rays, etc.) caused by direct radiation to tissue. Nasopharyngeal carcinoma is a relatively common type of head and neck tumors, with the highest incidence in southern China and the Guangdong and Guangxi regions. Currently, intensity-modulated radiation therapy is the preferred treatment for nasopharyngeal carcinoma. Because the anatomical location of the nasopharynx is close to the oropharynx and the oral cavity, acute radiation oral mucositis is the most common complication during radiotherapy for head and neck tumors when p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61K31/714A61K31/047A61K31/661A61K31/46A61P1/02
CPCA61K31/047A61K31/167A61K31/46A61K31/661A61K31/714A61P1/02A61K2300/00
Inventor 李轩段立洁
Owner JINSHAN HOSPITAL FUDAN UNIV