Composition for treating ulcerative colitis as well as granules and preparation method thereof

Abstract

The invention belongs to the technical field of drug preparations, and particularly relates to a composition for treating uclerative colitis as well as granules and a preparation method thereof. The composition is prepared from the following components in parts by weight: 5-12 parts of radix scutellariae, 1-5 parts of rhizoma coptidis, 5-10 parts of cortex phellodendri and 4-10 parts of treated folium artemisiae argyi. The granules are prepared from the following raw materials in parts by weight: 15-37 parts of the composition for treating ulcerative colitis, 0.5-2 parts of a sweetening agent,0.5-2 parts of micro powder silica gel, 1-3 parts of sucrose fatty acid ester, 0.5-1.5 parts of crospolyvinyl pyrrolidone and 3-6 parts of microcrystalline cellulose. The composition for treating ulcerative colitis has an outstanding treatment effect on ulcerative colitis; meanwhile, the granules prepared by applying the composition have good stability, are uniformly dispersed after being dissolved in water, has good taste and low toxic and side effects, and is suitable for being applied and popularized.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a composition for treating ulcerative colitis, granules thereof and a preparation method thereof. Background technique [0002] Ulcerative colitis is a disease caused by the interaction of genetic background and environmental factors. It is a chronic inflammatory response state. The lesions are continuous and can involve different parts of the rectum and colon. Clinically, it alternates with attack, remission and relapse. It is one of the common intractable diseases of the digestive system. The clinical manifestations of patients with ulcerative colitis are: diarrhea with mucus and pus and blood, 3 to 4 times a day in mild cases, dozens of times in severe cases, or alternating diarrhea and constipation, sometimes accompanied by other symptoms such as abdominal distension, weight loss, fatigue, intestinal Ming, insomnia, dreaminess, fear of cold em...

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Problems solved by technology

For example, Chinese patent document CN 103356845 A discloses a traditional Chinese medicine formula and preparation process for treating ulcerative colitis. ~15 parts, 3-12 parts of Cortex Phellodendri, 6-18 parts of Angelica, 6-18 parts of Dabupi, and 3-12 parts of Muxiang. Acute colitis has a certain therapeutic effect. The preferred dosage form of this traditional Chinese medicine formula is granules, but the taste of the formula is extremely bitter, which is not conducive to taking

Chinese patent document CN 101829219 A discloses a Periplaneta americana pharmaceutical composition for treating ulcerative colitis and a preparation method thereof. Composed of a mixture of ingredients, the ratio is 0.8-1.2: 0.1-2.5: 0.15-4.5: 0.15-6: 0.15-15. The preparation method of the composition is simple, and the effect of the Periplaneta americana extract is fully exerted, effectively improving the healing effect on ulcers. However, the main active ingredient Periplaneta americana extract has a certain degree of toxicity and has a pungent taste, which will have side effects on the human body

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