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A doxycycline thermosensitive in vivo gel uterine perfusion solution for sows and its preparation method

A technology of body gel uterus and doxycycline, which is applied in the field of doxycycline temperature-sensitive in vivo gel uterine perfusion solution and its preparation, can solve the problems of sick sows such as anorexia, failure to heal, and complicated etiology , to achieve strong tissue positioning, uterine positioning, and good biocompatibility

Active Publication Date: 2021-12-24
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, postpartum endometritis in sows is a deep infectious inflammation, and the etiology is more complicated and harmful. The sick sows are anorexic, depressed, and drinking water is reduced. Trouble requires a lot of manpower and material resources, etc.

Method used

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  • A doxycycline thermosensitive in vivo gel uterine perfusion solution for sows and its preparation method
  • A doxycycline thermosensitive in vivo gel uterine perfusion solution for sows and its preparation method
  • A doxycycline thermosensitive in vivo gel uterine perfusion solution for sows and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0053] 1. A doxycycline temperature-sensitive in vivo gel uterine perfusion solution for sows, consisting of the following components by weight percentage: doxycycline raw material 2%; poloxamer 40720%; poloxamer Sham 1885%; Magnesium chloride 4.6%; Sodium bisulfite 0.2%, pH adjuster ethanolamine (adjust pH to 4.0±0.2), balance water.

[0054] 2. The method for preparing the above-mentioned doxycycline thermosensitive in vivo gel uterine perfusion solution comprises the following steps:

[0055] S1. Sprinkle the prescribed amount of temperature-sensitive material and temperature regulator evenly on the water surface, stir evenly, and put it in a refrigerator at 4°C for 24 hours until it is fully swollen to form a clear solution;

[0056] S2. Add the metal complexing agent, antioxidant, and principal agent to the solution in step S1 in sequence, stir thoroughly, and dissolve by ultrasonic;

[0057] S3. Adjust the pH of the solution in step S2 to 4.0±0.2 with a pH regulator, an...

Embodiment 2

[0059] 1. A doxycycline temperature-sensitive in vivo gel uterine perfusion solution, which is composed of the following components in weight percentage: 2% of doxycycline raw material, 20% of poly-N-isopropylacrylamide, polyethylene glycol Alcohol 5%, magnesium oxide 4.6%, sodium thiosulfate 0.2%, pH regulator 10% sodium hydroxide, balance water.

[0060] 2. The method for preparing the above-mentioned doxycycline thermosensitive in vivo gel uterine perfusion solution comprises the following steps:

[0061] S1. Sprinkle the prescribed amount of temperature-sensitive material and temperature regulator evenly on the water surface, stir evenly, and refrigerate at 10°C for 12 hours to fully swell to form a clear solution;

[0062] S2. Add the metal complexing agent, antioxidant, and principal agent to the solution in step S1 in sequence, stir thoroughly, and dissolve by ultrasonic;

[0063] S3. Adjust the pH of the solution in step S2 to 4.0±0.2 with a pH regulator, and then put...

Embodiment 3

[0065] 1. A doxycycline temperature-sensitive in vivo gel uterine perfusion solution, consisting of the following components in weight percentage: 2% doxycycline raw material, 20% chitosan, 5% polyethylene glycol, EDTA -2Na 4.6%, sodium bisulfite 0.2%, pH adjuster 10% sodium hydroxide, the balance water.

[0066] 2. The method for preparing the above-mentioned doxycycline thermosensitive in vivo gel uterine perfusion solution comprises the following steps:

[0067] S1. Sprinkle the prescribed amount of temperature-sensitive material and temperature regulator evenly on the water surface, stir evenly, and wait for 36 hours in the refrigerator at 0°C to fully swell to form a clear solution;

[0068] S2. Add the metal complexing agent, antioxidant, and principal agent to the solution in step S1 in sequence, stir thoroughly, and dissolve by ultrasonic;

[0069] S3. Adjust the pH of the solution in step S2 to 4.0±0.2 with a pH regulator, and then put it in a refrigerator at 0° C. u...

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Abstract

The invention discloses a doxycycline temperature-sensitive in vivo gel uterine perfusion solution for sows and a preparation method thereof. The doxycycline temperature-sensitive in-body gel uterine perfusion fluid consists of a main drug, a temperature-sensitive material, a temperature regulator, a metal complexing agent, an antioxidant, a pH regulator and ultrapure water. The preparation has solution-gel transition properties and bioadhesive properties. Compared with conventional sow uterine perfusate, the preparation can rapidly transform from liquid to semi-solid gel at the administration site, allowing the perfusate to reach deeper layers of the uterus site, and can closely adhere to the surface of the uterine mucosa, has a long-term effect on the drug site, effectively prevents drug burst release, can achieve uterine positioning, sustained release, improve its clinical drug effect, and greatly improve the clinical drug use of this type of disease convenience. Moreover, the preparation process is simple, the product is stable and clear, can be stored at room temperature, is non-toxic, less irritating, and has good biocompatibility, and has good prospects for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of veterinary preparations. More specifically, it relates to a doxycycline thermosensitive in vivo gel uterine perfusion solution for sows and a preparation method thereof. Background technique [0002] In recent years, with the increasing subsidy policy for breeding sows in my country, the production scale of self-propagation and self-raising of sows has continued to increase, and the number of sows that can reproduce has continued to increase, and postpartum diseases of sows have also become more and more protrude. If the postpartum management of sows is not in place, it is easy to cause postpartum endometritis, mastitis, agalactia syndrome, etc., especially endometritis is more common, which seriously affects the production performance of sows. Sow endometritis is purulent or mucinous inflammation of pig uterine mucosa. It is caused by pathogenic microorganisms such as E. inflammatory process. Generall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/02A61K31/65A61P31/04A61P15/00
CPCA61K47/02A61K47/10A61P15/00A61P31/04A61K9/0034A61K9/08A61K31/65
Inventor 黄显会华成云刘宇麻雨桥王波王文湘胡大兴
Owner SOUTH CHINA AGRI UNIV
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