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Fluorcalcidol tablet and preparation method thereof

A technology of alcohol tablets and calcidol, which can be used in pill delivery, pharmaceutical formulations, bone diseases, etc., and can solve the problems of less flucalcidol and less preparation research

Active Publication Date: 2020-10-20
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Of these, flucalcidol has been less studied, and even fewer studies have been conducted on its preparations

Method used

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  • Fluorcalcidol tablet and preparation method thereof
  • Fluorcalcidol tablet and preparation method thereof
  • Fluorcalcidol tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0047] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

[0048] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as are familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

[0049] Study on Stability of Experimental Fluorcalcidol with Di...

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Abstract

The invention relates to a fluorocitol tablet, and belongs to the field of pharmaceutical preparations. The fluorocitol tablet is prepared from the following components in parts by weight: 0.1-0.5 part of fluorocitol, 22-32 parts of a diluent, 25-35 parts of an adhesive, 18-25 parts of a disintegrating agent and 0.5-5 parts of a lubricant, wherein the diluent is selected from sugar alcohols, the adhesive is selected from cellulose derivatives, and the disintegrating agent comprises one or two of sodium carboxymethylcellulose and calcium carboxymethylcellulose. According to the fluorocitol tablet, a formula of the fluorocitol tablet is optimized and screened, the stability test shows that the fluorocitol is combined with mannitol, sorbitol, lactose, powdered sugar, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methylcellulose, so that the use stability is relatively good, the screened formula taking the sodium carboxymethylcellulose and the calcium carboxymethylcellulose as the disintegrating agent is relatively good in stability, finally, the pharmacodynamics of the fluorocitol tablet is studied, and the test result shows that the effect of the fluorocitol tablet is superior to that of a calcitriol tablet.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a flucalcidol tablet and a preparation method thereof. Background technique [0002] Osteoporosis, or osteoporosis, is a group of bone diseases caused by a variety of reasons. Bone tissue has normal calcification, and the ratio of calcium salt to matrix is ​​normal. It is a metabolic bone lesion characterized by a decrease in the amount of bone tissue per unit volume. . In most cases of osteoporosis, the loss of bone tissue is mainly due to increased bone resorption. Characterized by bone pain and susceptibility to fractures. [0003] Effective drug therapy to prevent and treat osteoporosis, including estrogen replacement therapy, calcitonin, selective estrogen receptor modulators, and bisphosphonates, which prevent bone resorption but have very little effect on bone formation . Drugs used to treat and prevent the development of osteoporosis are divided into two cat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/592A61K47/26A61K47/38A61P19/10A61P3/02A61P13/12A61P5/16A61P17/06
CPCA61K9/2018A61K9/2054A61K31/592A61P3/02A61P5/16A61P13/12A61P17/06A61P19/10
Inventor 陈阳生王明刚孙桂玉刘晓霞王清亭杜昌余刘振玉臧云龙
Owner CP PHARMA QINGDAO CO LTD
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