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Biomarker for early warning of retained placenta of dairy cows and application thereof

A biomarker and retention of placenta technology, applied in biological testing, material inspection products, etc., can solve problems such as undetected blood urea nitrogen, achieve the effect of increasing economic income and improving production performance

Inactive Publication Date: 2019-04-16
HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology has not found whether blood urea nitrogen is related to the occurrence of retained placenta in dairy cows

Method used

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  • Biomarker for early warning of retained placenta of dairy cows and application thereof
  • Biomarker for early warning of retained placenta of dairy cows and application thereof
  • Biomarker for early warning of retained placenta of dairy cows and application thereof

Examples

Experimental program
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Embodiment Construction

[0022] The present invention will be described in detail below in conjunction with specific embodiments, but it should be understood that the protection scope of the present invention is not limited by specific embodiments. The test methods that do not indicate specific conditions in the following examples are usually operated according to conventional conditions, and the sources of unindicated test materials are commercially available. Since they do not involve the invention point, the steps are not described in detail.

[0023] The invention provides an application of blood urea nitrogen as a biomarker for early warning of retained placenta in dairy cows.

[0024] In order to verify the application, we conducted the following experiments.

[0025] (1) Validation of blood urea nitrogen as a biomarker for early warning of retained placenta in dairy cows

[0026] 134 peripartum dairy cows were selected from a pasture in Heilongjiang, and blood was collected from the tail vein ...

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Abstract

The invention belongs to the field of animal disease diagnostic reagents, and specifically relates to a biomarker for early warning of retained placenta of dairy cows and an application thereof. It isdiscovered for the first time that blood urea nitrogen (BUN) can be used as a biomarker for early discovery and early warning of retained placenta of the dairy cows, the optimal demarcation value isdetermined that the BUN is 10.25mg / dl at 7 days before delivery, the corresponding sensitivity is 52.9%, and the specificity is 92.3%. The biomarker provided by the invention has important significance for preventing retained placenta of the dairy cows, improving the productivity of the dairy cows and increasing the economic income.

Description

technical field [0001] The invention belongs to the field of reagents for diagnosing animal diseases, and in particular relates to a biomarker for early warning of dairy cow placenta retention and application thereof. Background technique [0002] During normal parturition in cattle, uterine smooth muscle contractions and immune responses contribute to the separation of the fetus and fetoplacenta from the mother. Under normal circumstances, depending on the parity and age of the delivery cow, the time for the fetus and fetal placenta to be discharged is also different, but the separation and inversion of the allantois will be completed within 8 hours after the start of delivery (the surface of the allantois is outward). All parts of the allantois and amniotic membrane need to be excreted within 0.5-12 hours after calving. However, not all cattle can successfully expel the fetal placenta within the specified time after delivery. The phenomenon that the fetal placenta cannot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N33/53
CPCG01N33/48G01N33/53
Inventor 鲁文赓原冬伟许美花孙宏亮金吉东
Owner HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY
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