Biological macromolecule nanosphere containing NADH and preparation method and application thereof
A biopolymer and nanosphere technology is applied in the field of biopolymer nanospheres containing NADH and its preparation, which can solve the problems of unstable chemical properties of NADH, difficult to store, and cannot be taken orally, so as to prolong the storage time, prevent cancer, The effect of reducing the difficulty of saving
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[0044] Example 1
[0045] This embodiment provides a NADH-containing biopolymer nanosphere, which, in parts by weight, includes 20 parts of a biopolymer carrier and 1 part of NADH. The NADH is dispersed on the biopolymer carrier. The particle size is 200-1000nm, and the average particle size of NADH-containing biopolymer nanospheres is 500-1000nm. In this embodiment, the material of the biopolymer carrier is konjac glucomannan (KGM), and KGM is a natural polymer soluble dietary fiber. The fiber has a honeycomb three-dimensional interpenetrating network structure, and the mesh size of the network structure is From tens to thousands of nanometers, NADH enters through the mesh and is loaded on the surface of the KGM fiber network. The biopolymer nanospheres also include auxiliary materials, and the auxiliary materials include 0.05 parts of sodium alginate in parts by weight. Sodium alginate is a natural polysaccharide, which has the ability to concentrate solution, form gel and fo...
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[0067] Example 2
[0068] This embodiment provides a NADH-containing biopolymer nanosphere, which, in parts by weight, includes 80 parts of a biopolymer carrier and 20 parts of NADH. The NADH is dispersed on the biopolymer carrier. The particle size is 200-1000nm, and the average particle size of the NADH-containing biopolymer nanospheres is 500-1000nm. In this embodiment, the material of the biopolymer carrier is a mixture of quaternized konjac glucomannan (QKGM) and carboxymethyl konjac glucomannan (CKGM), and the mass ratio of the two is 1:1. Modified KGM is a natural polymer soluble dietary fiber. The fiber has a honeycomb three-dimensional interpenetrating network structure. The mesh size of the network structure is tens to thousands of nanometers. NADH enters through the mesh and is loaded on the surface of the KGM fiber network.
[0069] The biopolymer nanospheres also include auxiliary materials. In this embodiment, the auxiliary materials include 30 parts by weight of sod...
Example Embodiment
[0075] Example 3
[0076] This embodiment provides a NADH-containing biopolymer nanosphere, which, in parts by weight, includes 45 parts of a biopolymer carrier and 5 parts of NADH. The NADH is dispersed on the biopolymer carrier. The particle size is 200-1000nm, and the average particle size of the NADH-containing biopolymer nanospheres is 500-1000nm. In this embodiment, the material of the biopolymer carrier is deacetyl konjac glucomannan (da-KGM), and the modified KGM is a natural polymer soluble dietary fiber, which has a honeycomb three-dimensional interpenetrating network structure. The mesh size of the network structure is tens to thousands of nanometers, and NADH enters through the mesh and is loaded on the surface of the KGM fiber network.
[0077] The biopolymer nanospheres also include auxiliary materials. In this embodiment, the auxiliary materials include 15 parts by weight of sodium alginate.
[0078] The NADH-containing biopolymer nanospheres described in this embodi...
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