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Application of evodine in preparation of anti-inflammatory medicine

A technology of rutaecarlide and anti-inflammatory drug, which is applied in the field of medicine and can solve the problems that there is no anti-inflammatory activity of rutadiellide

Inactive Publication Date: 2019-04-19
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no report of anti-inflammatory activity of evodiolide

Method used

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  • Application of evodine in preparation of anti-inflammatory medicine
  • Application of evodine in preparation of anti-inflammatory medicine
  • Application of evodine in preparation of anti-inflammatory medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] 1. Experimental materials

[0013] Lipopolysaccharides (LPS) were purchased from Sigma; dimethyl sulfoxide (DMSO) was purchased from Shanghai Macklin Biochemical Technology Co., Ltd.; Tianhang Biotechnology Co., Ltd.; DMEM high-glucose medium was purchased from Cellgro.

[0014] 2. Experimental method

[0015] 1. Cell culture

[0016] Take out the RAW264.7 cell line frozen in liquid nitrogen, quickly place it in a 37°C water bath and shake it until the cells melt, then transfer it to a centrifuge tube that has been added with the medium, centrifuge at 1000rpm for 5min, discard the supernatant, and add a small amount of Gently blow and aspirate the culture medium, the medium is DMEM high-glucose medium containing 10% fetal bovine serum and 1% double antibody, transfer the cell suspension into a culture dish, and store at 37°C, 5% CO 2 , cultured under saturated humidity conditions.

[0017] 2. Preparation of cell models

[0018] RAW264.7 cells in the logarithmic gro...

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Abstract

The invention discloses application of evodine in preparation of anti-inflammatory medicine. Inflammation caused by lipopolysaccharide is a classical inflammation molding model, and the expression level of related inflammation indexes such as IL-10 can be applied to indication of the seriousness degree of inflammation. In the experiment result, compared with a control group, the related index level of inflammation of the model group is obviously increased, and it is explained that the inflammation model is successfully molded. Compared with the model group, the related index level of inflammation in evodine group cells different in concentration is obviously lowered, the dose dependence is presented, it is explained that evodine has an obvious anti-inflammatory function, and evodine has the prospect of being developed into the anti-inflammatory medicine.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known compounds, in particular to the application of evodicarlide in the preparation of anti-inflammatory drugs. Background technique [0002] When infection and inflammation occur, the elevated level of inflammation-related indicators such as IL-10 is consistent with the severity of infection, and thus can be used to judge the severity of inflammation. [0003] So far, there is no report on the anti-inflammatory activity of evodiolide. Contents of the invention [0004] The object of the present invention is to provide the application of evodicarlide in the preparation of anti-inflammatory drugs. [0005] Above-mentioned purpose of the present invention is to realize by following technical scheme: [0006] Application of evodicarlide in the preparation of anti-inflammatory drugs. [0007] The application of the pharmaceutically acceptable salt of evodia lactone i...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P29/00
CPCA61K31/366A61P29/00
Inventor 谢治深袁永张振强高改王潘宋军营曾华辉王辉苏运芳李中华马金莲赵建平蒋亚丽张俊霞
Owner HENAN UNIV OF CHINESE MEDICINE