Longan leaf extract and preparation method and application

An extract and longan leaf technology, which is applied in the preparation and application of plant extracts, can solve the problem of not many longan leaves, and achieve the effect of abundant sources, low price, and controllable quality and safety

Inactive Publication Date: 2019-04-19
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are not many domestic research reports on longan leaves, mainly focusing on the extraction of flavonoids, and there is no extraction and separation method for its effective parts or extracts for lowering blood sugar

Method used

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  • Longan leaf extract and preparation method and application
  • Longan leaf extract and preparation method and application
  • Longan leaf extract and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of longan leaf extract comprises the following steps:

[0032] S1. Take 10 kg of dry longan leaves, crush them, use 95% ethanol and 50% ethanol to ultrasonically extract successively, filter, combine the extracts, recover the ethanol under reduced pressure and concentrate it into an extractum;

[0033] S2. Take the extract and add water to suspend, sequentially extract 3 times with petroleum ether (60-90°C), ethyl acetate, and n-butanol, and finally leave the water to obtain the corresponding extracts of each solvent;

[0034] S3. Take the extracts from each part, recover the solvent under reduced pressure, concentrate, and dry to obtain longan leaf petroleum ether extract, longan leaf ethyl acetate extract, longan leaf n-butanol extract, and longan leaf water extract.

Embodiment 2

[0036] The preparation method of longan leaf extract comprises the following steps:

[0037] S1. Take 10kg of dried longan leaves, pulverize them and extract them ultrasonically with absolute ethanol, and extract the extract under reduced pressure to reclaim ethanol to obtain an extractum;

[0038] S2. Take the ethanol extract and add water to suspend it, and then use petroleum ether (60-90° C.), ethyl acetate, and n-butanol to extract 3 times respectively, to obtain ethyl acetate extract and n-butanol extract;

[0039] S3. Take the ethyl acetate extract and the n-butanol extract respectively to recover the solvent under reduced pressure, concentrate and dry to obtain the longan leaf ethyl acetate extract and the longan leaf n-butanol extract.

Embodiment 3

[0041] The preparation method of longan leaf extract comprises the following steps:

[0042] S1. Take 10kg of dried longan leaves, crush them, extract them ultrasonically with 75% ethanol, filter, extract the extract under reduced pressure and reclaim ethanol to obtain an extractum;

[0043] S2. Take the extract and add water to suspend it, then extract with petroleum ether (30-60° C.), ethyl acetate and n-butanol for 3 times respectively to obtain ethyl acetate extract and n-butanol extract;

[0044] S3. Take the ethyl acetate extract and the n-butanol extract respectively to recover the solvent under reduced pressure, concentrate and dry to obtain the longan leaf ethyl acetate extract and the longan leaf n-butanol extract.

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Abstract

The invention discloses an extract prepared by extracting from longan leaves and having the activity of inhibiting alpha-glucosidase. The extract can be obtained by pulverizing the longan leaves and then performing ultrasonic extracting with ethanol, an ethanol extract is decompressed to recover ethanol, and then an extract is obtained by concentration, and the extract is suspended by adding water, the petroleum ether and ethyl acetate are used for extraction in order to obtain an ethyl acetate extract; and after extraction with the ethyl acetate, n-butanol is used for extraction to obtain then-butanol extract. Pharmacological experiments show that the effective part has a good inhibition of alpha-glucosidase activity, and the effect of ethyl acetate extract is more obvious. The method adopts the abundant and low-priced longan leaves as a raw material, and provides a wider source of diabetes therapeutic drugs, has good social value and economic value, and plays an important role in developing an efficient and safe hypoglycemic new drug.

Description

technical field [0001] The invention relates to the technical field of preparation and application of plant extracts, in particular to longan leaf extracts and a preparation method thereof, and also relates to applications of longan leaf extracts. Background technique [0002] With the continuous improvement of people's living standards and changes in diet structure, the number of diabetic patients is increasing year by year. Diabetes has become the "third killer" that threatens human beings after cardiovascular diseases and tumors. Therefore, the prevention and treatment of diabetes has become a global problem. . Diabetes is a metabolic disorder characterized by hyperglycemia. The first symptom in the pathogenesis is usually postprandial hyperglycemia, which is the early sign of diabetes. Especially in patients with type Ⅱ diabetes, postprandial hyperglycemia is not only It is very easy to induce various complications, and it will also greatly increase the mortality rate o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P3/10A61K127/00
CPCA61K36/77A61K2236/33A61K2236/333A61K2236/55
Inventor 梁洁黄春燕徐晖杨川川
Owner GUANGXI UNIV OF CHINESE MEDICINE
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