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A kind of hydrogel composite material for 3D printing and its preparation method and application

A composite material and 3D printing technology, applied in the field of 3D printing, can solve problems such as limited applications, achieve good biocompatibility, meet demand, and have abundant sources

Active Publication Date: 2021-06-29
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, chitosan has limited its application due to its insolubility in water

Method used

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  • A kind of hydrogel composite material for 3D printing and its preparation method and application

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preparation example Construction

[0038] In a second aspect, the present invention provides a method for preparing the above-mentioned hydrogel composite material, comprising the following steps:

[0039] Dissolving PEG-modified chitosan and gelatin with water to obtain solution A;

[0040] Dissolve α-cyclodextrin with an equal volume of water to obtain solution B;

[0041] Solution A and solution B were mixed to obtain a hydrogel composite material.

[0042] In the present invention, when dissolving PEG-modified chitosan, gelatin and α-cyclodextrin, the volume of water used is the same.

[0043] Specifically, the water is deionized water.

[0044] In a third aspect, the present invention provides an application of the above-mentioned hydrogel composite material in 3D printing.

[0045] Further, the method of 3D printing includes the following steps:

[0046] Fill the hydrogel composite material into the printing cylinder and place it in the printer water tank;

[0047]Take out the printing cylinder from ...

Embodiment 1

[0056] The molecular weight of 0.1g is 5×10 4 Da chitosan was dissolved in 20mL of MES buffer solution with a pH of 5.0, and a certain volume of dilute hydrochloric acid was added to promote dissolution; in addition, a certain amount of PEG-COOH with a molecular weight of 350Da was added to a round-necked flask to make it with The molar unit ratio of chitosan is 1:1, then add a certain amount of EDC and NHS to make the molar unit ratio of chitosan 4:1, dissolve it in 10mL MES buffer solution with pH 5.0, and react for one hour Finally, the mixed solution was added to the previously dissolved chitosan solution and reacted in the dark for 24 hours. The reacted solution was dialyzed in deionized water for 3 days with a dialysis bag with a molecular weight cut-off of 8000Da-14000Da, and finally PEG-modified chitosan powder was obtained by freeze-drying, and the grafting rate was calculated to be about 60%.

[0057] Get 0.2g of prepared PEG-modified chitosan powder and 0.2g of gel...

Embodiment 2

[0064] 0.1g molecular weight is 10 5 Da chitosan was dissolved in 20mL of MES buffer solution with a pH of 5.0, and a certain volume of dilute hydrochloric acid was added to promote dissolution; in addition, a certain amount of PEG-COOH with a molecular weight of 1000Da was added to a round-necked flask to make it with The molar unit ratio of chitosan is 1:1, then add a certain amount of EDC and NHS to make the molar unit ratio of chitosan 4:1, dissolve it in 10mL MES buffer solution with pH 5.0, and react for one hour Finally, the mixed solution was added to the previously dissolved chitosan solution and reacted in the dark for 24 hours. The reacted solution was dialyzed in deionized water for 3 days with a dialysis bag with a molecular weight cut-off of 8000Da-14000Da, and finally PEG-modified chitosan powder was obtained by freeze-drying, and the grafting rate was calculated to be about 60%.

[0065] Get 0.2g of prepared PEG-modified chitosan powder and 0.2g of gelatin pow...

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Abstract

The invention discloses a hydrogel composite material for 3D printing, a preparation method and application thereof. The present invention firstly discloses a hydrogel composite material for 3D printing. The hydrogel composite material comprises the following components in mass percentage: 10% to 40% of PEG modified chitosan, 10% to 40% % gelatin and 30% to 60% α-cyclodextrin. The invention further discloses the preparation method and application of the hydrogel composite material. In the present invention, when the hydrogel composite material is used for 3D printing, a supramolecular hydrogel system is formed by PEG and α-cyclodextrin before printing, and the remaining amino groups of chitosan and the amino groups in gelatin after printing are double physical cross-linked. The formation of ionic cross-links with sodium β-glycerophosphate improves the strength of the printed hydrogel model structure, and has good printability, biocompatibility and operability.

Description

technical field [0001] The invention relates to the technical field of 3D printing. More specifically, it relates to a hydrogel composite material for 3D printing and its preparation method and application. Background technique [0002] 3D printing technology has been widely used in aerospace, construction, electronic devices and other fields because of its ability to quickly and efficiently manufacture personalized products. Especially in recent years, with the continuous development of printing technology, material science and cell level, 3D printing technology has been introduced into the biological field more, making it possible to use 3D printing technology to obtain specific functional tissues, that is, 3D bioprinting technology. 3D bioprinting technology refers to a technology that can position and assemble biological materials or cell units according to the principle of additive manufacturing under the drive of digital three-dimensional models, and manufacture medi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/26B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/26A61L27/50A61L27/52A61L2430/02A61L2430/10A61L2430/24B33Y10/00B33Y70/00B33Y80/00C08L89/00C08L5/16C08L87/005
Inventor 牛忠伟崔晓亮吴曼
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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