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Anti-gastrointestinal cancer drug composition, preparation method and application thereof

A gastrointestinal cancer and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of poor anti-gastrointestinal cancer effect, low extraction rate of active ingredients, and many impurities, and achieve good anti-gastrointestinal cancer, good effect, low polysaccharide content high effect

Inactive Publication Date: 2019-04-26
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of the existing anti-gastrointestinal cancer pharmaceutical composition, such as poor anti-gastrointestinal cancer effect, low extraction rate of active ingredients and more impurities in the preparation method, and provide an active ingredient Anti-gastrointestinal cancer drug composition with high content, preparation method and application thereof

Method used

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  • Anti-gastrointestinal cancer drug composition, preparation method and application thereof
  • Anti-gastrointestinal cancer drug composition, preparation method and application thereof
  • Anti-gastrointestinal cancer drug composition, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0034] The pharmaceutical composition for resisting gastrointestinal cancer comprises the following raw materials and their parts by weight: 8 parts of Hericium erinaceus mycelium, 5 parts of Scutellaria barbata, and 2 parts of Hedyotis diffusa.

[0035] The preparation method of the pharmaceutical composition for resisting gastrointestinal cancer is as follows: 1) take Hericium erinaceus mycelium by the above weight parts, and use 22 times of water (that is, the quality of water is 20 times the quality of Hericium erinaceus mycelium) at room temperature Stir and soak for 2 hours, then heat up to 50°C and soak for 1.5 hours, filter to obtain the filtrate and filter residue, the filtrate is vacuum concentrated at 60°C to a relative density of about 1.07, the concentrated solution is freeze-dried, crushed to obtain Hericium erinaceus mycelia, water extraction and freezing dry powder;

[0036] 2) Weigh Scutellaria barbata and Hedyotis diffusa, add water to extract twice, add 12 t...

Embodiment 2

[0038] The pharmaceutical composition for resisting gastrointestinal cancer comprises the following raw materials and their parts by weight: 12 parts of Hericium erinaceus mycelium, 3 parts of Scutellaria barbata, and 3 parts of Hedyotis diffusa.

[0039] The preparation method of the anti-gastrointestinal cancer pharmaceutical composition is as in Example 1.

Embodiment 3

[0041] The pharmaceutical composition for resisting gastrointestinal cancer comprises the following raw materials and their parts by weight: 10 parts of Hericium erinaceus mycelium, 4 parts of Scutellaria barbata, 2 parts of Hedyotis diffusa, 2 parts of Panax notoginseng, and 2 parts of tangerine peel.

[0042] The preparation method of the pharmaceutical composition for resisting gastrointestinal cancer is as follows: 1) take Hericium erinaceus mycelium by the above weight parts, and use 22 times of water (that is, the quality of water is 20 times the quality of Hericium erinaceus mycelium) at room temperature Stir and soak for 2 hours, then heat up to 40°C and soak for 1.5 hours, filter to obtain the filtrate and Hericium erinaceus mycelium filter residue, the filtrate is vacuum concentrated at 60°C to a relative density of about 1.07, the concentrate is freeze-dried, and crushed to obtain Hericium erinaceus Silk water extraction freeze-dried powder;

[0043] 2) Weigh Panax ...

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Abstract

The invention discloses an anti-gastrointestinal cancer drug composition. The anti-gastrointestinal cancer drug composition is prepared from the following raw materials in parts by weight: 8-12 partsof hericium erinaceus mycelia, 3-5 parts of herba scutelellariae barbatae, 1-3 parts of herba hedyotis, 1-3 parts of radix notoginseng, and 1-3 parts of pericarpium citri reticulatae. A preparation method of the anti-gastrointestinal cancer drug composition comprises the following steps: performing aqueous extraction on the hericium erinaceus mycelia to obtain filtrate and filter residues, and concentrating and drying the filtrate to obtain hericium erinaceus mycelial dry powder; soaking the radix notoginseng with ethyl alcohol, and then adding the hericium erinaceus mycelia filter residues, performing alcohol extraction, filtering a extracting solution, and concentrating to form an extract; performing aqueous extraction on the herba scutelellariae barbatae, the herba hedyotis and the pericarpium citri reticulatae for two times, filtering, concentrating, merging concentrated solutions after two times of extracting and uniformly mixing with the obtained extract, and drying to obtain drypowder; and mixing the dry powder and the hericium erinaceus mycelial dry powder to obtain the anti-gastrointestinal cancer drug composition. According to the invention, aqueous extraction is separately performed on the hericium erinaceus mycelia, and ergosterol content in the obtained composition is relatively high; in an extracting process of radix notoginseng powder, the hericium erinaceus mycelial filter residues are added, so that an extraction ratio of a notoginsenoside component is improved, and the effect of resisting to anti-gastrointestinal cancer is relatively good.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an anti-gastrointestinal cancer drug composition, a preparation method and an application thereof. Background technique [0002] Gastrointestinal cancer is the most common malignant tumor of the digestive tract. my country is a high-incidence area of ​​gastrointestinal cancer, with the highest incidence in Northwest China. The detection rate of this disease has an increasing trend year by year. Gastrointestinal cancer is more common in people over 40 years old, 2 / 3 of them are 41-60 years old, and the ratio of male to female is about 3.6:1. Clinically, the treatment methods for gastrointestinal cancer mainly include surgery, radiotherapy and chemotherapy, and traditional Chinese medicine treatment, and the treatment principle is based on the combination of traditional Chinese and Western medicine. [0003] Hericium erinaceus is a mushroom (fung...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61P1/00A61P35/00
CPCA61K36/07A61K36/258A61K36/539A61K36/748A61K36/752A61K2236/331A61K2236/39A61K2236/51A61P1/00A61P35/00A61K2300/00
Inventor 何述金朱克俭夏新华周代俊周准
Owner HUNAN XINHUI PHARMA
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