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Triterpenoid compound in adiantum capillus-veneris, preparation method of triterpenoid compound and application of triterpenoid compound in electronic cigarettes

A technology of triterpenoids and bristle grass, which is applied in the field of phytochemistry, can solve the problems of no relevant reports in the application, and achieve good antifungal activity, reduce sweet and greasy feeling, and good antibacterial effect

Inactive Publication Date: 2019-05-10
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the compound and its application

Method used

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  • Triterpenoid compound in adiantum capillus-veneris, preparation method of triterpenoid compound and application of triterpenoid compound in electronic cigarettes
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  • Triterpenoid compound in adiantum capillus-veneris, preparation method of triterpenoid compound and application of triterpenoid compound in electronic cigarettes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A preparation method of triterpenoids in bristle grass, comprising the steps of:

[0044]Step (1), extraction of extract: crush the dry aboveground part of bristle grass to 30-50 mesh, use 70% ethanol aqueous solution as the extraction solvent, extract twice at room temperature, each time for 6 hours, filter the extract, Concentrate the filtrate under reduced pressure to obtain the extract;

[0045] Step (2), silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, the column silica gel is 200-300 mesh, and carry out gradient elution with a mixed organic solvent of petroleum ether and acetone; collect each gradient The gradient eluate was concentrated and monitored by TLC, and the same parts were combined to obtain seven parts A1-A7;

[0046] Step (3), gel chromatographic separation: use a mixed organic solvent of chloroform and methanol at a volume ratio of 1:1 as the eluent, and use gel chromatography to elute part...

Embodiment 2

[0048] A preparation method of triterpenoids in bristle grass, comprising the steps of:

[0049] Step (1), extraction of extract: crush the dry aboveground part of bristle grass to 30-50 mesh, use 95% ethanol aqueous solution as the extraction solvent, extract at room temperature 4 times, each time for 10 hours, filter the extract, Concentrate the filtrate under reduced pressure to obtain the extract;

[0050] Step (2), silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, the column silica gel is 200-300 mesh, and carry out gradient elution with a mixed organic solvent of petroleum ether and acetone; collect each gradient The gradient eluate was concentrated and monitored by TLC, and the same parts were combined to obtain seven parts A1-A7;

[0051] Step (3), gel chromatographic separation: use a mixed organic solvent of chloroform and methanol at a volume ratio of 1:1 as the eluent, and use gel chromatography to elute ...

Embodiment 3

[0056] A preparation method of triterpenoids in bristle grass, comprising the steps of:

[0057] Step (1), extraction of extract: crush the dried aboveground part of bristle grass to 30-50 mesh, use 80% ethanol aqueous solution as the extraction solvent, extract at room temperature for 3 times, each time for 8 hours, filter the extract, Concentrate the filtrate under reduced pressure to obtain the extract;

[0058] Step (2), silica gel column chromatography: apply the extract obtained in step (1) to silica gel column chromatography, the column silica gel is 200-300 mesh, and carry out gradient elution with a mixed organic solvent of petroleum ether and acetone; collect each gradient The gradient eluate was concentrated and monitored by TLC, and the same parts were combined to obtain seven parts A1-A7;

[0059] Step (3), gel chromatographic separation: use a mixed organic solvent of chloroform and methanol at a volume ratio of 1:1 as the eluent, and use gel chromatography to e...

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Abstract

The invention relates to a triterpenoid compound in adiantum capillus-veneris, a preparation method of the triterpenoid compound and application of the triterpenoid compound in electronic cigarettes,belonging to the technical field of phytochemistry. The structural formula of the compound is represented by a formula (I) (shown in the description). The compound is separated from the over-ground part of adiantum capillus-veneris for the first time and is determined as the triterpenoid compound by virtue of a magnetic resonance imaging and mass spectroscopy method, and a specific structure of the compound is represented. The compound presents remarkable antifungal activity to Helminthosporium maydis and Alternaria alternate, and the minimum inhibition concentration is 3.125ug / mL-12.5ug / mL. Meanwhile, the compound presents very good antifungal activity to Micrococcus lysodeikticus, Bacterium paratyphosum B and Pseudomonas aeruginosa and has very good application prospects, and the minimuminhibition concentration is 100ug / mL.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a triterpenoid compound in bristle grass, a preparation method thereof, and an application in electronic cigarettes. Background technique [0002] Bristle grass, the name of traditional Chinese medicine, is Adiantum plant Adiantum Adiantum capillus-veneris The whole plant of L. is distributed in East China, Central South, Southwest and Hebei, Shanxi, Shaanxi, Gansu and other places. It has the effects of clearing heat and detoxifying, promoting diuresis and treating stranguria. It can be used for cold and fever, lung heat cough, damp-heat diarrhea, dysentery, stranguria, leukorrhagia, breast abscess, scrofula, furunculosis, burns, snake bites. [0003] Triterpenoids are substances composed of several isoprenes connected end-to-end after removing hydroxyl groups. Most of them are 30 carbon atoms, and a small part are terpenoids with 27 carbon atoms. Triterp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24F47/00C07J63/00
Inventor 陈永宽赵伟洪鎏朱东来张霞巩效伟李寿波李廷华韩熠
Owner CHINA TOBACCO YUNNAN IND
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