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Micro-droplet generation device

A technology for generating devices and micro-droplets, which is applied in the direction of laboratory appliances, laboratory containers, chemical instruments and methods, etc., can solve problems that are not suitable for clinical testing applications, high cost, and high cost of batch processing of PDMS micro-droplet chips And other issues

Pending Publication Date: 2019-05-14
TARGETINGONE CORP +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hand-processed PDMS droplet chip has poor reliability
[0006] (2) The cost of batch processing of PDMS droplet chips is high
[0007] (3) PDMS micro-droplet chip sample injection and droplet collection are cumbersome manual procedures, which are not suitable for clinical testing applications
[0008] (4) Cross-contamination is prone to occur during droplet generation and collection
For RainDance’s micro-droplet generation device, oil phase samples need to be loaded with an external instrument, and the cost is high
The shortcomings of these micro-droplet generating devices limit their wide application in the field of clinical testing.

Method used

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Embodiment Construction

[0032] In order to enable those skilled in the art to better understand the technical solutions in the application, the present invention will be further described below in conjunction with the following examples. Obviously, the described embodiments are only a part of the embodiments of the application, rather than all Example. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the scope of protection of this application. The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0033] 1. Micro droplet generation device structure

[0034] Such as figure 1 As shown, the micro-droplet generation device of the present invention includes: a first part 1 and a second part 2, the first part 1 is a micro-droplet generation chip, and the second part 2 is micro-droplet sample loading and generation of droplet...

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Abstract

The invention provides a micro-droplet generation device. The micro-droplet generation device comprises a first part and a second part which are fixedly connected and is characterized in that the first part is a micro-droplet generation chip and used for generating micro-droplets; the second part is a micro-droplet sample feeding and micro-droplet collecting device and used for feeding the oil phase sample and water phase sample of the first part and collecting the generated micro-droplets. The micro-droplet generation device is capable of fast, reliably and parallelly generating uniform micrometer-scale 'water in oil' / 'oil in water' micro-droplets, low in material and batch processing cost, convenient in sample injection and droplet collecting and less prone to cross contamination in thewhole process.

Description

technical field [0001] The invention relates to the technical field of micro-droplet digital PCR, in particular to a micro-droplet generating device. Background technique [0002] Droplet digital PCR (ddPCR) is a technique for absolute quantitative analysis of nucleic acids based on single-molecule PCR. Micro-droplet digital PCR technology is becoming the next revolutionary technology in the industry due to its advantages of high sensitivity and high accuracy. In recent years, with the development of micro-nano fabrication technology and microfluidics technology (micro-nanofabrication and microfluidics), micro-droplet digital PCR technology has encountered the best opportunity to break through the technical bottleneck. This technology uses a microfluidic chip to generate droplets with a diameter of several microns to hundreds of microns; the microdroplets wrap single molecules or single cells to achieve fully closed and fully integrated reaction and detection. The working ...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 荆高山白宇王博苏世圣付明珠郭永王勇斗
Owner TARGETINGONE CORP
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