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Application of four-spirit powder aqueous extract in preparation of anti-Parkinson's disease medicine

A technology of water extract and Parkinson's disease, applied in the preparation of anti-Parkinson drugs, water extract of Sishen powder, the field of traditional Chinese medicine compound Sishen powder, can solve the problem that there is no treatment method and so on

Active Publication Date: 2019-06-07
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no effective treatment

Method used

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  • Application of four-spirit powder aqueous extract in preparation of anti-Parkinson's disease medicine
  • Application of four-spirit powder aqueous extract in preparation of anti-Parkinson's disease medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment one Sishensan water extract

[0015] Preparation of Sishen Powder by decoction: weigh 6g of Angelica sinensis, 6g of Chuanxiong, 6g of dried ginger, and 6g of Radix Paeoniae Rubra, add 200mL of distilled water, soak for 20min, heat and boil for 30min, filter out the medicinal residue with gauze, and collect the medicinal liquid For standby, soak the medicine dregs in 150ml distilled water for 5-10min again, heat to boil and keep for 25min, filter the medicine dregs again with gauze to obtain the supernatant, combine the two medicine liquids, concentrate and dilute to 50ml, centrifuge at 12000rpm*10min 2 times, discard the insoluble precipitate, use a 0.22um water filter head to filter and sterilize, and store at -20°C after aliquoting.

Embodiment 2

[0016] The preparation of embodiment two comparative water extracts

[0017] Preparation of comparative preparations by decoction: Weigh 6 g of Angelica sinensis, 6 g of Rhizoma Chuanxiong, and 6 g of dried ginger, add 200 mL of distilled water, soak for 20 minutes, heat to boil and keep for 30 minutes, filter off the medicinal residue with gauze, collect the medicinal liquid for later use, and remove the medicinal residue Soak again in 150ml of distilled water for 5-10min, heat to boil and keep for 25min, filter out the medicinal residue with gauze again to obtain the supernatant, combine the two medicinal solutions, concentrate and dilute to 50ml, centrifuge twice at 12000rpm*10min, discard For the insoluble precipitate, use a 0.22um water filter head to filter and sterilize, and store it at -20°C after aliquoting.

Embodiment 3

[0018] The preparation of embodiment three Rhizoma Chuanxiong water extract

[0019] Preparation of Rhizoma Chuanxiong by decoction: Weigh 6g of Rhizoma Chuanxiong, add 200mL of distilled water, soak for 20min, heat to boil and keep for 30min, filter off the medicinal residue with gauze, collect the medicinal liquid for later use, soak the medicinal residue in 150ml of distilled water for 5-10min again , heated and boiled and kept for 25 minutes, then filtered off the medicinal residue with gauze to obtain the supernatant, combined the two medicinal solutions, concentrated and settled to 50ml, centrifuged twice at 12000rpm*10min, discarded the insoluble precipitate, and filtered with 0.22um water system Filter and sterilize, and store at -20°C after aliquoting.

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Abstract

The invention belongs to the field of biological medicine, provides a novel application of an aqueous extract of four-spirit powder, which is a traditional Chinese medicine compound, and concretely relates to an application of the four-spirit powder in preparation of anti-Parkinson's disease medicine. A result of an in-vivo experiment carried out by using model organism caenorhabditis elegans shows that the four-spirit powder aqueous extract can significantly inhibit expression of alpha-synuclein, which suggests that the four-spirit powder aqueous extract provided by the invention can be applied to the preparation of the anti-Parkinson's disease medicine.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of a traditional Chinese medicine compound Sishen powder. Specifically, the invention provides an application of an aqueous extract of Sishen powder in preparing anti-Parkinson medicine. Background technique [0002] Parkinson's disease (PD) is the second most common neurodegenerative disease, manifested by the decline of motor ability and cognitive function. Motor performance is manifested by muscle stiffness, bradykinesia, and tremor; behavioral and cognitive performance is manifested by dementia, depression, anxiety, and sleep disturbance. The incidence of this disease increases rapidly in people over 60 years of age. The quality of life of patients continues to decline with the development of the disease, until it becomes a burden on the family, bringing a heavy burden to society and the family. [0003] The main pathological feature of Parkinson's disease is the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/16
Inventor 李红玉朱澍芊支德娟李洋戴治娟
Owner LANZHOU UNIVERSITY
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