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Application of balicatinib in the preparation of anti-filovirus infection drugs

A technology of balicativa and virus infection, which is applied in the field of medicine, can solve the problem of anti-filovirus of balicatix, and achieve the effect of high clinical value, epidemic relief and mild side effects

Active Publication Date: 2022-07-15
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the literature, there is no report on the anti-filovirus (including Ebola virus, Marburg virus, Cueva virus) or any anti-viral activity of balicati

Method used

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  • Application of balicatinib in the preparation of anti-filovirus infection drugs
  • Application of balicatinib in the preparation of anti-filovirus infection drugs
  • Application of balicatinib in the preparation of anti-filovirus infection drugs

Examples

Experimental program
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Embodiment Construction

[0043] Example balicatinib anti-filovirus activity

[0044] 1. The principle of screening model

[0045] Filovirus entry into host cells is the first step in viral infection, and inhibition of viral entry can effectively block viral infection. Glycoprotein (GP) on the surface of filovirus envelope is a key protein in the entry process of filovirus.

[0046] The present invention applies filovirus envelope GP gene, including Zaire Ebola virus Mayinga strain envelope GP gene (EBOV-Mayinga GP, Gene Accession No. L11365), Zaire Ebola virus Makona strain Envelope GP gene (EBOV-Makona GP, Gene Accession No.KJ660346.2), Sudan Ebola virus envelope GP gene (EBOV-Sudan GP, ​​Gene Accession No.FJ968794.1), Cote d'Ivoire Ebola virus Envelope GP gene (EBOV- Forest GP, Gene Accession No.FJ217162.1), Reston type Ebola virus envelope GP gene (EBOV-Reston GP, ​​Gene Accession No.U23152.1), Bandibugyo type Ebola virus envelope GP gene (EBOV-Bundibugyo GP, Gene Accession No. KR063673.1); Ma...

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Abstract

The invention discloses the application of balicarat in anti-filovirus infection. The present invention includes the application of balicatinib in the prevention or treatment of filovirus infection or the combined application with other antiviral drugs.

Description

technical field [0001] The invention relates to the application of balicatib (Balicatib, CAS: 354813-19-7) in anti-filovirus infection, and belongs to the technical field of medicine. The present invention encompasses the single or combined use of balicatinib in filovirus prophylaxis or treatment. Background technique [0002] Filoviruses belong to the Filoviridae family (Filoviridae), including three viruses: Ebola virus (EBOV), Marburg virus (Marburg virus, MARV), Cueva virus (Cuevavirus, LLOV). Both Ebola and Marburg are controlled viruses and are classified as Class A bioterrorism agents, and live viruses need to be completed in a Biosafety Level 4 (P-4) laboratory [Centers for Disease Control and Prevention / NationalInstitutes of Health. Biosafety in Microbiological and Biomedical Laboratories. 4th ed. Washington, DC: U.S. Department of Health and Human Services, U.S. Government Printing Office; 1999. DHHS Publication CDC 93-8395.]. Human infection with these two virus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/495A61P31/14
Inventor 郭颖陈盼盼陈勍唐克
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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