Application of eupatilin in preparing drug for treating or preventing glioma

A technology of eupholzanthin and glioma, applied in the application field of medicine, can solve the problem of high treatment cost

Inactive Publication Date: 2019-06-14
中国人民解放军总医院第七医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, drug-targeted therapy represented by the monoclonal antibody bevacizumab has emerged, but there is a problem of high treatment cost

Method used

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  • Application of eupatilin in preparing drug for treating or preventing glioma
  • Application of eupatilin in preparing drug for treating or preventing glioma
  • Application of eupatilin in preparing drug for treating or preventing glioma

Examples

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Embodiment Construction

[0019] The application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain related inventions, rather than to limit the invention. It should also be noted that, for ease of description, only parts related to the invention are shown in the drawings.

[0020] It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and embodiments.

[0021] Based on the background of the above-mentioned therapeutic effects of eupholzanthin on various tumors, the present inventors discovered the therapeutic effect and mechanism of eupholzanthin on glioma through in vitro cell experiments and in vivo nude mouse tumor formation experiments.

[00...

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Abstract

The invention provides application of eupatilin or a computer of eupatilin in preparing a drug composition for treating or preventing glioma. Treating or preventing the glioma is achieved by inhibiting the cellular activity of a glioma cell line by the eupatilin, or treating or preventing the glioma is achieved by inhibiting proliferation of the glioma cell line by the eupatilin, or treating or preventing the glioma is achieved by inhibiting the cyclical change of tumor cells by the eupatilin, or treating or preventing the glioma is achieved by inhibiting cell migration of the tumor cells by the eupatilin, or treating or preventing the glioma is achieved by inhibiting invasiveness of the tumor cells by the eupatilin. The application overcomes the severe shortcomings of single drug and drugresistance in the existing treatment or prevention of the glioma.

Description

technical field [0001] The present disclosure generally relates to new uses of eupatilin, and particularly relates to the application of eupatilin in the preparation of drugs for treating or preventing glioma. Background technique [0002] Glioma is the most common primary brain tumor arising from the canceration of glial cells in the brain and spinal cord. The annual incidence is about 3-8 per 100,000 population. Like other tumors (diseases), glioma is also caused by the interaction of innate genetic risk factors and environmental carcinogenic factors. Some known genetic diseases, such as neurofibromatosis (type I) and tuberculous sclerosis, are genetic susceptibility factors for glioma. Gliomas are divided into grade 1 (the lowest degree of malignancy and the best prognosis) to grade 4 (the most malignant degree and the worst prognosis) according to the degree of malignancy. Among them, the so-called anaplastic glioma in traditional cytopathology corresponds to WHO grad...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P35/00A61P35/04
Inventor 费晓炜徐如祥王重伍汪继陈晨丁柏匀陈文锦孙凯
Owner 中国人民解放军总医院第七医学中心
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