Preparation method of medical micromolecular pectin

Abstract

The invention discloses a preparation method of medical micromolecular pectin. The method comprises the following steps of pretreatment, extraction, separation, purification and drying. The cellulaseand nitric acid are used for treatment; the extraction time is about 2 hours. Compared with a conventional acidolysis method, the preparation method has the advantages that the extraction efficiency can be greatly improved; the pectin molecules can be more dispersed through cellulase; the content of small molecule pectin in the solution is further improved; vacuum concentration and alcohol precipitation are used for purifying small molecule pectin; the purification purity is higher; the impurity content is small; the quality of the small molecule pectin is very good. The process design is reasonable; the obtained small molecule pectin has very good use effects in aspects of capsules of colloidal bismuth pectin capsules and the like.

Description

technical field

[0001] The invention belongs to the technical field of high molecular pectin production, in particular to a preparation method of medicinal small molecular pectin. Background technique

[0002] Pectin is a kind of galacturonic acid polymer that constitutes the structural components of cells, and is widely found in the cell walls of roots, stems, leaves, and fruits of various plants. Pectin has the functions of antibacterial, hemostasis, detumescence, detoxification, antidiarrheal, hypolipidemic, anti-radiation, etc. Material. However, the molecular chain of natural pectin is relatively large and cannot be absorbed by the human body. As a carrier for intravenous injection, polymer drugs need to control the molecular weight within a certain range. Studies have found that the molecular weight of pectin used as a carrier in the kidney excretion in the body should be controlled below 50,000, that is, small molecule pectin is more suitable for medical use, so a r...