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Apparatus and method for measuring concentration, size and zeta potential of liquid nanoparticles in scattered light mode and fluorescence mode

A technology of nano-particles and light scattering, which is applied in the field of size and zeta potential devices and concentration, and can solve problems such as the difficulty of approaching particles

Active Publication Date: 2021-11-12
PARTICLE METRIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At this point, use the fact that the approach of particles charged in the same way is made more difficult by their electrostatic repulsion

Method used

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  • Apparatus and method for measuring concentration, size and zeta potential of liquid nanoparticles in scattered light mode and fluorescence mode
  • Apparatus and method for measuring concentration, size and zeta potential of liquid nanoparticles in scattered light mode and fluorescence mode
  • Apparatus and method for measuring concentration, size and zeta potential of liquid nanoparticles in scattered light mode and fluorescence mode

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Embodiment Construction

[0035] figure 1 An icon of Particle Metrix's proprietary PTA nanoparticle tracking measurement device is shown.

[0036] In the PTA, the imaging optics unit consists of an objective lens 6 directed at the particulate sample 28 in a measurement unit 29 and a camera for recording the particle motion. Laser 1 is used as an excitation light source for scattered light and fluorescence, and is usually irradiated at an angle of 90 degrees. Here, via the beam path 11, the scattered light from the scattered light plane 31 and the The light from the fluorescent plane 30 is recorded synchronously by the camera 5 or detector.

[0037] Both scattered light and fluorescence are emitted simultaneously by the same particle, the scattered light always having a high intensity. The resulting problem is that the orders of magnitude weaker fluorescence must be separated from the much stronger scattered light signal by optical edge filters. Due to the necessary resolution and high sensitivity...

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Abstract

The present invention relates to a device and method for measuring the concentration, size and zeta potential of nanoparticles in a liquid in scattered light mode and fluorescence mode, comprising the following features: a) a sample (28) is passed from above by a laser beam through a beam splitter (14) and an adjustable focus liquid lens (9) and the reflected beam of light is deflected to the detector (5) by the same beam splitter (14) and another liquid lens (8) and analyzed; b ) for the purpose of observing fluorescence, a fluorescence filter (19) is connected to the converging beam path between the liquid lens (8) and the detector (5) to increase the scattered light plane (31) and The distance between the fluorescent planes (30); and c) to control the measurement process, a particle tracking program, an optical controller (15) and a display (2) with a touch screen are used.

Description

technical field [0001] The present invention relates to a device and method for measuring the concentration, size and zeta potential of nanoparticles in a liquid in scattered light mode and fluorescence mode. Background technique [0002] Evaluation can be achieved by PTA (Particle Tracking Analysis; forthcoming ISO TS19430) or heterodyne DLS (Dynamic Light Scattering; ISO 22412). [0003] Suspensions and emulsions, which are systems of dispersed matter, are common forms of particles in liquids. Applications range from printer inks to cosmetic emulsions and pharmaceutical preparations. It is well known that dispersed systems are classified as thermodynamically unstable systems. The duration for which this dispersion remains stable is critical for applicability. Instability, which can be observed very frequently, arises through agglomeration of particles, which can lead to irreversible particle size growth or complete separation between liquid and particle phases. A numbe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/02G01N21/64
CPCG01N2015/0053G01N15/0211G01N2015/0222G01N2015/0038G01N2015/1027G01N2015/1029G01N27/44721
Inventor 哈诺·法其尼格玛格丽特·布克
Owner PARTICLE METRIX