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Nematicidal fungus and anthelmintic combination preparation

A nematicidal and anthelmintic technology, applied in the directions of drug combination, fungal medical raw materials, pill delivery, etc., can solve the problems of affecting the use effect, fungal spore germination, increasing labor and time costs, etc. Good application prospect, easy to use effect

Active Publication Date: 2019-06-25
INNER MONGOLIA AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The team's research found that the combined application of Dudingtoniaflagrans and anthelmintics has been proven to be the most effective clinical application method for nematode fungi, which can not only kill adult nematodes in livestock, but also reduce the number of nematodes in the excreted feces of animals after deworming. Eggs hatch into larvae and continue to infect livestock; however, in clinical practice, two preparations of anthelmintic and fungal suspension are fed separately, which increases labor and time costs and brings a lot of inconvenience to animal husbandry production
In addition, during the storage and transportation of D. flagrans chlamydospore suspension, it is easy to cause the germination of fungal spores and affect its use effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of fungal D.flagrans-ivermectin joint preparation capsule

[0043] A capsule comprising a capsule shell, chlamydospores of the nematicidal fungus (Duddingtonia flagrans) (provided in the form of freeze-dried spore powder), and ivermectin. Each unit dose contains 40.1 mg of freeze-dried spore powder of nematicidal fungi and 1.0 mg of ivermectin.

[0044] The capsule shell model is 3#, about 15mm in length, and about 5mm in diameter. Divide the capsule shells into three groups, and each group has three parallel samples, which are precisely weighed, and the mass is within the range of 0.0622±0.0166g / capsule.

[0045] Calculated by formula (1), the net weight of the fungus and ivermectin mixture in each capsule is about 0.04g / capsule.

[0046] Present embodiment provides the preparation method of above-mentioned capsule simultaneously, specifically as follows:

[0047] Preparation of capsules: Arrange the 3# capsule body and capsule cap on the body...

Embodiment 2

[0090] A tablet consisting of freeze-dried spores of nematicidal fungi, albendazole, magnesium stearate, and a-lactose, each unit dose contains approximately 53.0 mg of freeze-dried spores of nematicidal fungi, albendazole 79.00mg, magnesium stearate 0.53mg, a-lactose 44.00mg.

[0091] This embodiment also provides the preparation method of the tablet, which is as follows: according to the ratio of the above-mentioned determined raw materials and auxiliary materials, weigh the raw powder and lactose of the active ingredients, mix well, sieve and granulate; then add stearin Magnesium acid, and then mix; use a tablet machine to compress tablets. Considering the problem of smooth feeding, the size of the tablet should be made as small as possible, with a diameter of about 7mm and a thickness of 4.5mm.

Embodiment 3

[0118] Adopt the tablet of embodiment 2, in animal husbandry production, directly mix in the feed, the sheep is easy to eat, does not need to expend manpower to feed medicine separately. In Inner Mongolia, for the two peak periods of parasitic infection in spring and winter, the combined preparations were given once each, which effectively improved and improved the actual effect of nematode infection prevention and control.

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Abstract

The invention provides a nematicidal fungus and anthelmintic combination preparation, wherein the active ingredients of the combination preparation are nematocidal fungus chlamydospore spore and an anthelmintic, wherein the anthelmintic is ivermectin or albendazole. The dosage form of the combination preparation is a tablet or a capsule. The successful preparation of the nematicidal fungus-ivermectin capsule and nematicidal fungi-albendazole combination preparation opens up a new mode of clinical application of nematicidal fungi at home and abroad, which is more convenient in clinical use, thepreparation further improves the efficiency of killing livestock parasites, and is more beneficial to the promotion and application of high-tech biological control technologies. The combination preparation is also beneficial to alleviate the problems of drug resistance, food safety and environmental pollution caused by drug residues. Under the current situation of sustainable and rapid development of animal husbandry in China, a mode of the nematicidal fungus and anthelmintic combination preparation is applied to the prevention and control of livestock parasitic nematodes in China, which is of great significance and has the very good application prospect.

Description

technical field [0001] The invention belongs to the field of animal biotechnology, and in particular relates to a parasitic infection prevention and control preparation for livestock. Background technique [0002] At present, the development of biological control in the field of veterinary parasitic nematode disease prevention and control in my country is still relatively slow, especially the research on its clinical application is still relatively small. Nematodes are the most common, most diverse, and most harmful type of parasites in animals. Its repeated infection is the most difficult problem in the prevention and control of animal parasites, because generally speaking, anthelmintics can only remove adult worms, and the eggs discharged from the disintegration of the uterus after the adult worms are killed are basically useless. With the grazing of livestock after deworming, the feces pollute the pasture everywhere, and the eggs can continue to develop into larvae to con...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61K31/7048A61K31/4184A61K9/48A61K9/20A61P33/10
Inventor 杨晓野王瑞王文蕊罗晓平乔蕾
Owner INNER MONGOLIA AGRICULTURAL UNIVERSITY
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