An injection composition comprising hyaluronidase for removal of topical fat

An injection composition, hyaluronidase technology, applied in the direction of enzymes, hydrolytic enzymes, glycosylases, etc., can solve problems such as unavoidable side effects, achieve skin lifting effect, slim and smooth skin regeneration, skin elasticity Keep the effect

Inactive Publication Date: 2019-06-25
孙维那
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composition also uses a high dose of hyaluronidase, and the injection of the composition is carried out at 4 to 6 points with an inte

Method used

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  • An injection composition comprising hyaluronidase for removal of topical fat
  • An injection composition comprising hyaluronidase for removal of topical fat

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0072] [Example] Preparation of injection composition

[0073] ingredient

[0074] For hyaluronidase, Liporase Inj. (1500IU / vial, including 13.3mg lactose hydrate) of Daehan New Pharm Co., Ltd was used, in which lidocaine (Hanmi Pharm. Co., Ltd.), pheniramine (Yuhan Co.), L-carnitine (Dream Pharma), and vitamin C (Daewoo Pharm Co., Ltd.), and the mixture was dissolved in a saline solution to prepare a 100cc injection solution composition .

Example Embodiment

[0075] [Example 1]

[0076] Lipolysis of the injection composition of the present invention

[0077] The changes in waist circumference after application of the injection composition of Example 4 and the injection compositions of Comparative Examples 1 to 3 and after cellulite endomology treatment for edema were measured and presented in Table 2.

[0078] The subjects of treatment were 40 patients (20 males, 20 females) with abdominal obesity and a BMI of 25 or higher, selected from adult outpatients aged 20 or above.

[0079] In the abdominal region between the ribs and the pubic bone, 1 cc of the injection composition was injected at 50 points, which were arranged at intervals of 1 cm from the belly button. Repeat the above injection every week for four weeks, each time you need to move the injection point. The reduction in waist circumference was measured 1 week after the completion of the treatment, and then measured again 1 month after the completion of the treatment. The aver...

Example Embodiment

[0090] [Example 2]

[0091] Evaluation of the side effects of the injection composition of the present invention

[0092] The injection compositions of Examples 1 to 4 and the injection compositions of Comparative Examples 1 to 3 were administered as in Example 1, and the side effects observed in each patient in the clinical trial are shown in Table 3.

[0093] [table 3]

[0094]

[0095] *Skin elasticity is determined by tactile evaluation using a 5-point scale: 1: very poor, 2: poor, 3: fair, 4: good, 5: very good.

[0096] As shown in Table 3, using the injection composition according to Example 1 of the present invention without a local anesthetic or antihistamine, compared with the high-dose composition of Comparative Example 2, side effects (for example, bruising or depression) Significant reduction, but pain and allergic reactions were observed. Compared with Example 1 or Comparative Example 2, the compositions of Examples 2, 3, and 4 containing local anesthetics and antihist...

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Abstract

The present invention relates to an injection composition comprising hyaluronidase for topical fat reduction. More particularly, the present invention relates to an injection composition comprising 300 IU to 600 IU of hyaluronidase and a local anesthetic, an antihistamine, a lipolysis stimulator and a collagen production stimulator. Still more particularly, the present invention relates to an injection composition for topical fat removal comprising 300 IU to 600 IU of hyaluronidase and, based on the weight of the total composition, 0.08 to 0.4 % by weight of a local anesthetic, 0.01 to 0.02 %by weight of an antihistamine, 0.01 to 4.0 % by weight of a lipolysis stimulator, and 0.1 to 2.0 % by weight of a collagen production stimulator, with the remainder being saline solution The present invention promotes the reduction of topical fat tissue, thereby improving obesity and helping weight loss and maintenance of body shape while preventing side effects or skin imbalance by the even removal of fat. Further, at the same time, the present invention can achieve a skin lifting effect where skin resilience is maintained by the stimulation of collagen production.

Description

technical field [0001] The present invention relates to an injectable composition comprising hyaluronidase for local fat removal. More specifically, the present invention relates to an injectable composition comprising 300 IU to 600 IU of hyaluronidase and one or more of local anesthetics, antihistamines, lipolysis stimulators and collagen production stimulators. Further, the present invention relates to a method for reducing localized fat by injecting an injection composition comprising 300 IU to 600 IU of hyaluronidase and one or more of local anesthetics, antihistamines, lipolysis stimulating agents and collagen production stimulators. Background technique [0002] With the recent increase in the obese population, obesity is receiving increasing attention, the number of obesity clinics is increasing, and various social problems caused by obesity are becoming a problem. [0003] In simple terms, obesity is defined as the excessive accumulation of body fat and leads to ad...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K31/4402A61K31/205A61K31/375A61K9/00A61K31/167A61K8/64A61Q19/06
CPCA61K8/44A61K2800/782A61K45/06A61K8/20A61K8/4926A61K8/66A61K8/676A61K9/0019A61K9/08A61K31/167A61K31/195A61K31/375A61K31/4402A61K38/47A61K47/02A61K2800/91A61Q19/06C12Y302/01035A61K2300/00A61K8/64A61K31/205A61K8/41A61K8/42
Inventor 孙维那
Owner 孙维那
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