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Whole body hyperthermia system
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A whole body, body technology, applied in the field of anti-tumor compounds, can solve the problems of lack of safety, small discomfort and high efficiency, and achieve the effect of small damage
Active Publication Date: 2021-12-21
ELMEDIX BVBA
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Problems solved by technology
[0009] Lack of methods and devices that allow long-term whole-body hyperthermia with maximum safety, minimum discomfort, and high efficiency
Method used
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Examples
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example 1
[0213] Example 1. In vitro model for optimization of the first heating device.
[0214] A fibroblast cell line (normal human dermal fibroblasts (NHDF)) and a tumor cell line were incubated in 5% CO 2 Culture in DMEM with fetal bovine serum in an incubator. Suitable cell lines are eg HeLa cells, HT-1080 (connective tissue cell line with activated N-ras oncogene), A375 (malignant cutaneous melanoma cell line) and A549 (adenocarcinoma human alveolar basal epithelial cells).
[0215] Cells were placed in an incubator at 37°C and then the temperature was raised to 41.5°C over a period of time ranging from 30 minutes to 4 hours. The volume of medium on the cells is kept to a minimum to avoid delays in heating.
[0216] Determine cell viability and measure apoptosis and necrosis of cells.
[0217] This experiment allowed to determine the effect of a slow or sharp increase in temperature achieved by the first device when applied on the body.
example 2
[0218] Example 2. In vitro model for determining efficiency and specificity.
[0219] The above cells were cultured at different temperatures (37, 39, 40, 40.5, 41, 41.5 and 42° C.) for different time periods (4, 6, 8, 12, 16, 20, 24, 36 hours).
[0220] Determine cell viability and measure apoptosis and necrosis of cells.
[0221] This experiment allowed to determine the efficiency (percentage of tumor cells killed) and specificity (percentage of tumor cells killed versus normal cells killed) of the method.
[0222] The system described above can further be used to simulate conditions (hypoxia, pH) in tumor tissue and determine the effect on cells that have been treated or irradiated with cancer drugs.
example 3
[0223] Example 3. In vivo model for long-term hyperthermia.
[0224]Place tumor-bearing mice under anesthesia on a heating plate in a heating cabinet. For small laboratory animals, heat transfer is sufficient to provide whole body hyperthermia without the use of the first and second devices as described in the specification.
[0225] Mice were sacrificed and tumor tissues were examined for cell death.
[0226] The animal model allows comparing the cell death obtained in Example 2 and the mouse model using the same time period and the same temperature.
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Abstract
The present invention relates to whole-body hyperthermia systems for raising the body temperature of an individual's entire body to a predetermined target temperature T b and stabilize the body temperature at the target temperature T b , said system comprising means having a patient therein for raising said body temperature at a rate of at least 1 °C / hour and for further regulating body temperature to said target temperature T b at least a second thermal device, wherein said second thermal device comprises a fluid circuit at least partly inside the individual, which is heated to a set temperature T by a heat exchanger f The fluid circulates through the fluid circuit.
Description
technical field [0001] The present invention relates to a whole-body hyperthermia system for raising an individual's body temperature to a predetermined target temperature T b and stabilize the body temperature at the target temperature T b . The invention also relates to methods of subjecting a patient to whole body hyperthermic conditions and antineoplastic compounds for use in the treatment of, eg, cancer. Background technique [0002] Cancer therapy aims to remove the maximum amount of tumor tissue while sparing as much healthy tissue as possible. However, surgery and irradiation are applied locally, and the few cancer cells far from the intervention site are not detected or removed. Also, chemotherapy usually does not kill all tumor cells. [0003] Therefore, alternative antineoplastic therapies are needed. [0004] Tumor cells have been described to be sensitive to stressful conditions, such as elevated temperature. Indeed, treatment at temperatures between 40 an...
Claims
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Application Information
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