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Flow cell device based on micro-cantilever sensor

A technology of micro-cantilever beam and flow cell, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of complex structure of flow cell, difficult operation of micro-cantilever beam, and inability to protect micro-cantilever beam, so as to reduce damage and ensure stability sexual effect

Inactive Publication Date: 2019-07-05
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the document "An optimized measurement chamber for cantilever array measurements in liquid incorporating an automated sample handling system", the structure of the flow cell used by the author is extremely complicated, and the clamping part is simply placed in the groove by the micro-cantilever beam, and a wedge block is used Pressed on the micro-cantilever beam and fixed by screws, the operation of placing the micro-cantilever beam is difficult, and the micro-cantilever beam cannot be effectively protected

Method used

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  • Flow cell device based on micro-cantilever sensor
  • Flow cell device based on micro-cantilever sensor
  • Flow cell device based on micro-cantilever sensor

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Such as figure 1 , figure 2 , image 3 As shown, a flow cell device based on a micro-cantilever beam sensor includes:

[0019] A flow cell substrate (1), the substrate is made of a cylinder made of stainless steel, the inside of the flow cell is in a three-level stepped shape, the groove (12) for placing the micro-cantilever beam is located on the step, and the top of the flow cell is sealed with a sealing ring ( 13), the glass sheet (10) and the metal cover plate (8) are fixed on the substrate (1) by screws (6) to form a closed environment;

[0020] A micro-cantilever clamping device (4), composed of a compression spring (7), a hemispherical working part (14) and a clamping base (4).

Embodiment 2

[0022] A flow cell device based on a micro-cantilever beam sensor uses the following steps:

[0023] The micro-cantilever beam used in the device is selected from the popular micro-cantilever beam of the German Micro-motive company Octo500c on the market, and the length and width are both 2.5mm;

[0024] Loosen the screw (6) with a screwdriver, and remove the metal cover (8), glass (10), and sealing ring (13); press the rear of the micro-cantilever clamping device (4), and the compression spring (7) is pressed Compression, the hemispherical part (14) at the front of the micro-cantilever clamping device (4) is lifted up, slowly put the micro-cantilever (3) into the notch of the micro-cantilever (12) with tweezers, and carefully adjust the position , and then slowly loosen the rear part of the micro-cantilever beam clamping device (4), the compression spring (7) rebounds, and the front hemispherical part (14) of the micro-cantilever beam clamping device (4) presses the micro-can...

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Abstract

The invention relates to a flow cell device based on a micro cantilever beam sensor. The flow cell device comprises a micro cantilever beam clamping device, a flow cell base body, a sealing ring, a transparent glass plate, a metal cover plate and a solution inlet and outlet pipeline, wherein the micro cantilever beam clamping device is composed of a compression spring with good tensile performance, a hemisphere and a micro cantilever beam clamping device base body; left and right ends of the flow cell base body are solution inlet and outlet, and the micro cantilever beam is placed in a grooveon a stair; the sealing ring, the glass plate and the metal cover plate are sequentially installed on the flow cell to create a closed environment; while the detection function of the micro cantileverbeam sensor is realized, the amount of the reaction solution flowing into the flow cell can be reduced, the waste is reduced, and the micro cantilever beam is protected to some extent.

Description

technical field [0001] The invention relates to a design of a flow cell device, in particular to a flow cell device based on a micro-cantilever beam sensor. Background technique [0002] Micro-Electro-Mechanical Systems (MEMS) is a micron-scale technology with electrically actuated mechanisms. The size of a typical MEMS component is 1-100 μm, and the size of the entire MEMS device is 20 μm-1 mm. Using microcantilever beam, the simplest MEMS element, by detecting the resonant frequency and deflection of microcantilever beam, real-time detection of specific biochemical reactions on the surface of microcantilever beam has the advantages of high sensitivity, no need for labeling, and real-time detection. At present, the existing flow cell devices at home and abroad are complex in structure, cumbersome in operation and mostly made of expensive materials, and cannot effectively protect the micro-cantilever beam during use. The flow cell and the micro-cantilever play a vital role...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N29/02G01N29/036G01N33/543B01J19/00
CPCB01J19/00B01J19/0073G01N29/022G01N29/036G01N33/54306
Inventor 丁松年唐毓李世琴梅永松张钊魏慧敏
Owner ANHUI UNIV OF SCI & TECH