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Preventive and therapeutic approach for aberrant cell differentiation and isr-associated diseases

A disease, phosphorylation technology, applied in metabolic diseases, bone diseases, medical preparations containing active ingredients, etc., can solve problems such as deficiency

Pending Publication Date: 2019-07-05
THE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] Although the stress response often leads to apoptosis, current understanding of how cells adapt, survive, and molecularly understand the consequences of ISR induction on cell fate and differentiation in vivo is still lacking

Method used

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  • Preventive and therapeutic approach for aberrant cell differentiation and isr-associated diseases
  • Preventive and therapeutic approach for aberrant cell differentiation and isr-associated diseases
  • Preventive and therapeutic approach for aberrant cell differentiation and isr-associated diseases

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Embodiment Construction

[0029]The present invention provides a method of preventing, ameliorating and / or treating conditions, diseases or disorders associated with the integrated stress response (ISR) that interacts with eukaryotic initiation factor 2α ( p-eIF2α) pathway phosphorylation. As described herein, the eukaryotic initiation factor 2α pathway in which phosphorylation is involved, or the p-eIF2α pathway includes signaling pathways in which phosphorylated eIF2α or phosphorylated eIF2α are involved, and include dephosphorylation by eIF2α directly or indirectly or phosphorylation-affected signaling pathways.

[0030] ISR-related skeletal disorders

[0031] A first aspect of the present invention is to provide a method of preventing, ameliorating and / or treating a skeletal disorder associated with or caused by activation of the integrated stress response in a subject. Skeletal disorders to which the present invention is applicable may be caused by cellular stress, such as oxidative stress, hy...

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Abstract

What is described is a method of preventing, ameliorating and / or treating disorders or diseases associated with integrated stress response (ISR) involving the p-eIF2[alpha] pathway arising from various cellular stresses such as oxidative stress, hypoxia and ER stress, chronic or prolonged bio-mechanical stress. In one embodiment, it provides a method which prevents or alleviates aberrant cell differentiation that is caused by the activation of the integrated stress response and thereby prevents or alleviates conditions, disorders or diseases resulting therefrom. In one embodiment, ISR-associated diseases subject include but are not limited to skeletal dysplasias, cancers, inflammatory diseases, diabetes, fibrosis, obesity and neurodegenerative diseases. In another embodiment, it provides amethod of using a p-eIF2[alpha]-modulator for the prevention or treatment of conditions, disorders or diseases described herein.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application 62 / 398,514, filed September 22, 2016, the entire disclosure of which is incorporated herein by reference. This application also cites various publications, which are hereby incorporated by reference in their entireties. technical field [0003] The present application relates to a method for preventing, improving and / or treating diseases and disorders associated with an integrated stress response to cellular stress involving the phosphorylated eukaryotic initiation factor 2α (p-eIF2α) pathway. In one embodiment, the present invention provides a method of preventing or reducing abnormal differentiation of cells associated with the p-eIF2α pathway. Background technique [0004] Humans acquired congenital skeletal disorders lead to physical disabilities and difficulties in education, employment, and social life (1). Children who are particularly short...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61P19/08A61P3/08A61P29/00A61P35/00
CPCA61K31/165A61K31/519A61P3/08A61P29/00A61P35/00A61P19/08A61P19/00A61K31/136A61K31/47A61K31/4965C07C235/14C07C211/29C07C235/20
Inventor 谢赏恩陈振胜王承陈卓荣
Owner THE UNIVERSITY OF HONG KONG
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