Pneumatically actuated microdroplet generation device and method for regulating microdroplet size
A technology for pneumatically driven and generating devices, which is applied to chemical instruments and methods, laboratory containers, laboratory utensils, etc., and can solve the problems of increasing device cost and increasing device inflexibility
Active Publication Date: 2021-03-16
BEIJING UNIV OF TECH
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Problems solved by technology
According to this approach, having several different types of nozzles in reserve will increase the corresponding cost of the device, and changing nozzles will also increase the inflexibility of the device
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[0017] Microdroplet generating devices such as figure 1 As shown, it consists of a single liquid storage chamber 6, a single high-speed solenoid valve 2, a pressure regulating valve 3, an air intake path 4, an exhaust path 1, a nozzle 9, a pressure sensor 7, a CCD camera 8, an LED light 10 and a liquid filling hole 5 components; the liquid storage chamber 6 is used to store liquid, the solenoid valve 2 is used to control the opening and closing of the air pressure, the pressure regulating valve 3 adjusts the air pressure, the pressure sensor 7 monitors the pressure in the liquid storage chamber, and the CCD camera 8 monitors the micro-liquid drop, and use the image processing program to calculate the size of the micro-droplet, adjust the start time of the solenoid valve 2 according to the calculated size, the LED lamp 10 provides a light source for the CCD camera 8, and the liquid filling hole 5 is used to inject liquid into the liquid storage chamber .
[0018] The specific ...
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The invention discloses a pneumatically-driven micro-droplet generation device and a method for regulating size of micro-droplets. The device and the method are mainly applied in the fields of precisebiomedical micro-sample application, biological 3D printing, etc. A single high-speed solenoid valve controls the turn-on time of air pressure; a pressure-regulating valve is used for controlling theintensity of air pressure; a single liquid storage chamber is used for storing a liquid, and the bottom of the single liquid storage chamber is provided with a single micropore which is connected with a nozzle; and the center of the micropore diameter is aimed at the center of the single liquid storage chamber. When the single high-speed solenoid valve opens, Helmholtz oscillation is generated inthe single liquid storage chamber, pressure intensity in the single liquid storage chamber rapidly oscillates and attenuates, pressure intensity in the liquid storage chamber will be lower than the atmospheric pressure in the next 3-4 periods, and finally the air pressure inside and outside the single liquid storage chamber tends to balance. Though a CCD camera for monitoring the size of sprayedmicro-droplets, the expected size of micro-droplets is determined, thereby lowering corresponding equipment cost and reducing equipment inflexibility caused by replacement of the nozzle.
Description
technical field [0001] The invention relates to a micro-droplet generation device driven by pneumatics. By adjusting the opening time of the solenoid valve in the device, the control technology for adjusting the size of micro-droplets is realized. It is mainly used in the fields of precision biomedical micro-sample application, biological 3D printing, etc. Background technique [0002] With the development of biotechnology, micro-droplet generating devices have been designed and realized, and their applications in the biological field are becoming more and more extensive. The common injection methods mainly include piezoelectric-driven injection, thermal bubble-driven injection, and pneumatic-driven injection. It has been widely used because of its high survival rate and other advantages. In the practical application of a pneumatic-based micro-droplet generating device, micro-droplets of different sizes are usually ejected according to requirements. Micro-droplets. Accord...
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IPC IPC(8): B01L3/00
CPCB01L3/5027
Inventor 王志海王一玮王飞
Owner BEIJING UNIV OF TECH