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Compound preparation for treating oral ulcer and preparation method thereof

A compound preparation, oral ulcer technology, applied in the field of pharmaceutical preparations, can solve problems such as covering up the cause, and achieve the effects of complex combination, overcoming limitations, and difficult process

Pending Publication Date: 2019-07-23
FUZHOU CHENXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, oral ulcers are a signal of human illness or sub-health. Even if symptomatic treatment is effective, although it reduces the pain of the patient, it also covers up the real cause

Method used

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  • Compound preparation for treating oral ulcer and preparation method thereof
  • Compound preparation for treating oral ulcer and preparation method thereof
  • Compound preparation for treating oral ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0058] The preparation method of embodiment 1-4 and comparative example 1-4 is as follows:

[0059] (1) Pretreatment: Take the vitamin mixture, mineral mixture and Chuanxiong extract and pass through a 40-mesh sieve, and the Danshen extract and direct-pressing filler pass through a 80-mesh sieve.

[0060] (2) The vitamin mixture, mineral mixture, Chuanxiong extract, Danshen extract, and direct-pressing filler weighed according to the above-mentioned prescription proportions are mixed uniformly in an equal increasing manner to obtain an intermediate.

[0061] (3) Test the intermediate, and adjust the tablet press to press the tablet after passing the test.

[0062] In Comparative Examples 1 and 2, the influence of different direct compression fillers on the results was investigated. When pregelatinized starch was used as the direct compression filler, the difference in tablet weight was unqualified, the hardness of the tablet was not enough, and cracks appeared in the friabilit...

Embodiment 5

[0063] Embodiment 5 Solubility experiment

[0064] Take 6 tablets obtained in Example 1 according to "Chinese Pharmacopoeia" 2015 edition two detection-paddle method, rotating speed 50 rpm, with 900 ml respectively, concentration is 0.1mol / L hydrochloric acid solution (pH 1.2), acetic acid-sodium acetate buffer solution (pH4.5), phosphate buffer (pH6.8), water as the dissolution medium, 37±0.5°C, 1, 2, 5, 8, 10, 20, 30, 40, 60, 120 min sampling 2 mL (At the same time, add the same amount of dissolution medium at the same temperature, filter with a 0.8 μm microporous membrane, take 10 μL of the subsequent filtrate for HPLC determination, and calculate the cumulative dissolution of the drug. The results are shown in figure 1 ,Depend on figure 1 It can be seen that ligustrazine is completely released in different dissolution media, and the dissolution curve is less affected by pH, which indicates that it can be better released in vivo and exert its drug effect.

Embodiment 6

[0065] Embodiment 6 drug effect test

[0066] According to previous studies and curative effect observations, the compound tablet obtained in Example 1 has an effective rate of more than 95% in treating oral ulcers, and the recurrence rate within 6 months is almost zero.

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Abstract

The invention relates to a compound preparation for treating oral ulcer and a preparation method thereof. Each preparation unit of the compound preparation comprises the following components in percentage by mass: 16.67 to 28.57 percent of a vitamin mixture, 27.50 to 47.14 percent of a mineral mixture, 1.50 to 2.57 percent of danshen root extract, 0.83 to 1.43 percent of Sichuan lovage rhizome extract and 20.29 to 53.50 percent of microcrystalline cellulose. The preparation method sieves and mixes the components, and directly performs tabletting, and the main medicine of ligustrazine can be well dissolved out. According to the invention, from the viewpoint of balancing nutrients and improving microcirculation, vitamins and minerals are combined with traditional Chinese medicines for promoting blood circulation and removing blood stasis to be prepared into compound tablets, capsules and other oral dosage forms which can treat and prevent oral ulcer well.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound tablet, capsule and other oral preparations for preventing and treating oral ulcers. Background technique [0002] Oral ulcer is a common oral mucosal disease, which is more common in the inner lip, tongue, soft palate and other parts. When it occurs, the pain is severe and the local burning pain is obvious. In severe cases, it will affect eating and speaking, causing great inconvenience to daily life. Commercially available medicines for the treatment of oral ulcers include iodine-containing tablets, dexamethasone acetate pasting tablets, vitamin B2 tablets, and compound Chinese medicine preparations. The main component of iodine-containing tablets is iodine, which is mainly used for sterilization and disinfection. Oral ulcers are not caused by bacterial infections, and at most they can only prevent secondary infections, and the effect is not very significan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61K9/48A61P1/02A61K31/07A61K31/355A61K31/59A61K31/714A61K33/06A61K33/26A61K33/34
CPCA61K36/537A61K36/236A61K31/07A61K31/355A61K31/59A61K31/714A61K33/06A61K33/26A61K33/34A61K9/2095A61K9/2054A61K9/4866A61P1/02A61K2300/00
Inventor 陈丽余越
Owner FUZHOU CHENXING PHARMA
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