A click chemistry method for rapid preparation of micron-scale functionalized porous polymer microspheres

Abstract

The invention relates to a method for rapidly preparing micron-scale functionalized porous polymer microspheres by click chemistry. A solution of polyvinylpyrrolidone and a polar solvent is used as a continuous phase, multifunctional thiol, multifunctional isocyanate and The other polar solvent is the dispersed phase, which rapidly reacts at normal temperature and pressure to generate porous polymer microspheres, and the diameter of the polymer microspheres is within 1-10um. Different from the traditional preparation of porous polymer microspheres, the click chemistry method does not require the addition of porogens, and the preparation process is simple, the reaction is rapid and efficient, and it is green and environmentally friendly, and is easy to industrialize production. The click chemistry with simple preparation process, rapid reaction and high efficiency and environmental protection generates nano-sized spheres first, and then the spheres react with each other through the functional groups on the surface, so that the spheres are connected together to form micro-sized spheres. During the connection of the beads, pores are formed between the beads, and finally porous polymer microspheres with uniform size are formed.

Description

technical field [0001] The invention belongs to a preparation method of polymer material microspheres, and relates to a method for rapidly preparing micron-scale functionalized porous polymer microspheres by click chemistry. Background technique [0002] With the development of material science, polymer microspheres with high strength, large specific surface area, easy functionalization, and light weight are more and more favored by researchers engaged in the research of carriers and separation and purification of functional polymer materials. How to control the structure of the polymer so that it has a high specific surface area and is easy to be functionalized is a difficult point in the preparation of materials. As an efficient and environmentally friendly chemical reaction, click chemistry has made a lot of achievements in the field of polymer microsphere preparation, but it is still very difficult to prepare porous microspheres by using click chemistry. Generally, the s...

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Problems solved by technology

This method is cumbersome and greatly increases the cost of material preparation. At the same time, some porogens remain in the closed pores inside the polymer microspheres, which seriously affects the later application of the microspheres.

In addition, the traditional preparation method takes a long time and consumes a lot of energy, which urgently needs to be improved.

[0004] So far, there are many reports on the preparation of polymer microspheres by click polymerization, but few reports on the preparation of porous polymers by click polymerization.

The inventor's research group has reported the preparation of microspheres by click suspension polymerization plus porogen, but there is no report on the preparation of porous microspheres by click polymerization without porogen

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