Nanoemulsion mouthwash and its preparation method and application method

A nanoemulsion and mouthwash technology, which is applied in the field of oral health care, can solve problems such as potential safety hazards, and achieve high safety, enhanced water dispersibility, and low equipment and energy consumption requirements

Active Publication Date: 2022-03-15
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mouthwash products containing chemically synthesized drugs have great potential safety hazards for users

Method used

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  • Nanoemulsion mouthwash and its preparation method and application method
  • Nanoemulsion mouthwash and its preparation method and application method

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preparation example Construction

[0026] A second aspect of the invention provides a method of preparing the above nano-emulsion type mouthwell, the preparation method comprising:

[0027] (1) Mix the Tween, ethanol, thymephenate and lemon essential oils are mixed, resulting in an oil phase;

[0028] (2) Mix the sorbitol and water and give aqueous phase;

[0029] (3) The oil phase and the aqueous phase are mixed well to obtain the nano-emulsion type mouthwater.

[0030] According to the present invention, preferably, step (1) is mixed with spitting and ethanol, then adding thymethyl acetate and lemon essential oil to mix well, to obtain an oil phase.

[0031] According to the present invention, preferably, in step (1), the mixed temperature is 20-30 ° C.

[0032] As a preferred embodiment, the components of the nano-emulsion type mouthwater of the present invention can be prepared by commercially available.

[0033] A third aspect of the present invention provides an application of the above nano-emulsion type mou...

Embodiment 1

[0037] In this embodiment, a nano-emulsion type mouthwater is provided. The specific preparation method is: weigh 10g Tween-80, 2G absolute ethanol in a 100 ml round bottom flask, stirred at room temperature for 15 minutes, then separate; add 0.4g thyme Phenol acetate and 0.2 g of lemon essential oils and continued to stir for 1 hour to form a uniform oil phase; mixed 0.5 g of sorbitol and 49.5 g of distilled water uniform, resulting in aqueous phase; mixed the oil phase and the aqueous phase, stirred to clear and transparent In the uniform state, the nano-emulsion type mouthwash is obtained.

Embodiment 2

[0039] This example provides a nano-emulsion type mouthwater, and the specific preparation method is: weigh 10 g of Tween-80, 2G anhydrous ethanol in a 100 ml round bottom flask, stirred at room temperature for 15 minutes, then 0.3 g of thyme phenol, respectively. Acetate and 0.3 g of lemon essential oils were continued for 1 hour to form a uniform oil phase; mixed 0.5 g of sorbitol and 49.5 g of distilled water uniform, gave aqueous phase; mixed the oil phase and the aqueous phase, stirred to clarify and transparent State, obtain the nano-emulsion type mouthwater.

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Abstract

The invention discloses a nanoemulsion type mouthwash and its preparation method and application method. Based on the total weight of the nanoemulsion type mouthwash, the mouthwash comprises: thymol acetate 0.2-0.7wt%, lemon essential oil 0.2 ‑0.7wt%, Tween 10‑20wt%, sorbitol 0.5‑1.5wt%, ethanol 2‑5wt%, and water 72‑87wt%. The active ingredient thymol acetate of the present invention has excellent bactericidal activity, especially has better bactericidal effect on Streptococcus mutans that causes dental caries; lemon essential oil has antibacterial activity and the effect of keeping breath fresh; the nanometer prepared by the present invention The emulsion type mouthwash can significantly enhance the water dispersibility of thymol acetate and lemon essential oil, and enhance the adsorption and bactericidal activity of the active ingredients.

Description

Technical field [0001] The invention belongs to the field of oral health care, and more particularly to a nano-emulsion type mouthwash and a preparation method thereof and a method of application. Background technique [0002] With the constant impact of people's living standards and the influence of flat bad habits, many oral problems, such as gingivitis, periodontitis, dental disease, etc., etc., thereby causing many troubles in life. The latest research shows that the bacteria in the periodontitis is the potential "behind-the-scenes hand" of Alzheimerism. Therefore, the cleaning and health of the oral cavity has an increasingly important impact on our lives and health. [0003] The advent of mouthwater products provides extremely convenient and practical choices to realize oral cleaning. Some chemical synthetic drugs contained in mouthwash can prevent and control the role of oral diseases to achieve an ideal effect. However, mouthwash with chemical synthetic drugs has a lot of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/06A61K8/34A61K8/37A61K8/49A61P1/02A61P31/04A61Q11/00
CPCA61K8/922A61K8/345A61K8/34A61K8/37A61K8/4993A61K8/06A61Q11/00A61P1/02A61P31/04
Inventor 贺军波黄双双齐玉堂韩立娟
Owner WUHAN POLYTECHNIC UNIVERSITY
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