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Hemodialysis concentrate

A technology of hemodialysis and concentrate, applied in the field of hemodialysis, can solve the problem of no components that can improve the anemia of patients, and achieve the effect of preventing the loss of iron and improving the therapeutic effect.

Pending Publication Date: 2019-07-30
吉林省富生医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no component in hemodialysis solution that can improve anemia in patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) Before dialysis:

[0070] Blood side: normal saline, added with 85.9 mg of ferrous gluconate iron supplement, which is equivalent to 11.0 μmoL / L of iron ions;

[0071] Dialysate side: the formula of dialysis concentrate is selected from formula 1 in table 2, and wherein selected pH regulator is acetic acid, and selected iron replenishing agent is ferrous gluconate; And according to A: B: water=1:1.225: After 32.775 dilution, the ion concentration in the dialysate is shown in Table 3:

[0072] Ion concentration and pH value in dialysate after dilution in Table 3 Example 1

[0073]

[0074] (2) After dialysis:

[0075] The iron ion content in the blood and dialysate side after dialysis was detected by an automatic biochemical analyzer, and the results are shown in Table 4.

[0076] Table 4 Iron ion content in blood and dialysate after dialysis, unit: mmoL / L

[0077] sample test 1 Test 2 Test 3 Test 4 Test 5 average normal saline 10.5...

Embodiment 2

[0079] (1) Before dialysis:

[0080] Blood side: normal saline, added with 85.9 mg of ferrous gluconate iron supplement, which is equivalent to 11.0 μmoL / L of iron ions;

[0081] Dialysate side: the formula of dialysis concentrate is selected from formula 2 in table 2, and wherein selected pH regulator is citric acid, and selected iron supplement is ferrous gluconate; And according to A: B: water=1: After 1.225:32.775 dilution, the ion concentration in the dialysate is shown in Table 5:

[0082] Ion concentration and pH value in dialysate after dilution in Table 5 Example 2

[0083]

[0084] (2) After dialysis:

[0085] The iron ion content in the blood and dialysate side after dialysis was detected by an automatic biochemical analyzer, and the results are shown in Table 6.

[0086] Table 6 Iron ion content in blood and dialysate after dialysis, unit: mmoL / L

[0087] sample test 1 Test 2 Test 3 Test 4 Test 5 average normal saline 12.71 12.69...

Embodiment 3

[0089] (1) Before dialysis:

[0090] Blood side: normal saline, added with 85.9 mg of ferrous gluconate iron supplement, which is equivalent to 11.0 μmoL / L of iron ions;

[0091] Dialysate side: the formula of the dialysis concentrate is selected from the formula described in formula 3 in table 2, wherein the selected pH regulator is lactic acid, and the selected iron supplement is ferrous gluconate; and according to A: B: water = After 1:1.225:32.775 dilution, the ion concentration in the dialysate is shown in Table 7:

[0092] Ion concentration and pH value in dialysate after dilution in Table 7 Experimental Example 3

[0093]

[0094] (2) After dialysis:

[0095] The iron ion content in the blood and dialysate side after dialysis was detected by an automatic biochemical analyzer, and the results are shown in Table 8.

[0096] Table 8 Iron ion content in blood and dialysate side after dialysis Unit: mmoL / L

[0097] sample test 1 Test 2 Test 3 Test 4 ...

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Abstract

The invention belongs to the technical field of hemodialysis and particularly provides a hemodialysis concentrate. The concentrate contains an iron supplement, and the iron content of the hemodialysisconcentrate is 107.8-215.6 mg / L. The provided hemodialysis concentrate can achieve slow perfusion of iron which is lost in a dialysis process during specific application, and the perfusion process issimilar to a substitution process of magnesium, potassium, calcium and the like during dialysis. The provided hemodialysis concentrate can convey iron ions in a dialysate form, and an innovative method for treating anemia of patients is provided. During dialysis, once iron is introduced into blood, the iron is immediately combined with transferrin and then conveyed into the bone marrow for hematopoiesis. According to an experimental result of the embodiment, the provided hemodialysis concentrate can ensure the temperature of iron in the blood and prevent the iron in the blood from being lost.

Description

technical field [0001] The invention relates to the technical field of hemodialysis, in particular to a hemodialysis concentrate. Background technique [0002] Hemodialysis uses artificial methods to imitate the filtering function of the human kidney. Under the condition of extracorporeal circulation, it removes excess nitrogen-containing compounds, metabolic products or excess drugs and other toxic substances in the human blood, and adjusts the balance of water and electrolytes. Healing function. [0003] In my country, due to the limited source of kidney transplant donors, dialysis treatment (hemodialysis or peritoneal dialysis) will be an important way of life maintenance and long-term treatment for patients with end-stage renal disease (ESRD, uremia). Anemia is one of the more common complications of hemodialysis patients, which can lead to long-term fatigue, low appetite, cognitive and physical decline, sleep disturbance, depression, and affect physical function, menta...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K31/295A61K47/02A61P7/08A61P7/06
CPCA61K31/295A61K33/26A61K47/02A61P7/06A61P7/08A61K2300/00
Inventor 张海悦魏滢王姝孙景春吴悦
Owner 吉林省富生医疗器械有限公司
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