T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta

A cell and cell receptor technology is applied in the field of a carrier for producing the polypeptide of the present invention, a monovalent CD123-binding polypeptide, and a kit for providing the polypeptide of the present invention, which can solve problems such as manufacturing
CN110177809AActive Publication Date: 2019-08-27ABLYNX NV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ABLYNX NV
Publication Date
2019-08-27

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Abstract

Polypeptides are provided that bind CD123 on a target cell and the constant domain of TCR on a T cell. The polypeptides can be used in methods for treatment of CD123 associated cancers or inflammatoryconditions.
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Description

[0001] field of invention

[0002] The present invention provides a multispecific T cell recruitment polypeptide comprising an immunoglobulin single variable domain that specifically binds to the constant domain of a T cell receptor (TCR), and one or more CD123 that binds to a CD123 expression expressed on a target cell. immunoglobulin single variable domain. The invention also relates to monovalent CD123-binding polypeptides useful in these multispecific polypeptides. The present invention also provides nucleic acids encoding the polypeptides as well as vectors, hosts and methods for producing the polypeptides of the present invention. The invention also relates to methods of treatment utilizing the polypeptides of the invention and kits providing the polypeptides of the invention. Background technique

[0003] CD123 (alpha subunit of the interleukin 3 receptor, IL-3Rα) is a 75 kDa glycoprotein that becomes 43 kDa after digestion with N-glycosidase (Sato et al., 1993, Blood...

Claims

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