Fiber wound repair scaffold loaded with phase change material particles and its preparation method and application

A technology for phase change materials and wound repair, which is applied in fiber processing, textiles, papermaking, bandages, etc. It can solve the problems of unable to adjust the timing and on-demand release of functional substances such as bioactive factors and antibacterial drugs, and achieve biodegradable performance Good, good biocompatibility, effect of improving wound healing effect

Active Publication Date: 2022-07-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current research on scaffold materials based on electrospinning mainly focuses on blending or post-processing antibacterial drugs and growth factors with electrospun nanofiber membranes. Most of the scaffolds obtained are simple composite scaffolds. Unable to adjust the timing and on-demand release of functional substances such as bioactive factors and antibacterial drugs

Method used

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  • Fiber wound repair scaffold loaded with phase change material particles and its preparation method and application
  • Fiber wound repair scaffold loaded with phase change material particles and its preparation method and application
  • Fiber wound repair scaffold loaded with phase change material particles and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] To prepare the solution:

[0074] Take metronidazole and add it to N,N-dimethylformamide, fully stir and ultrasonic to dissolve it to obtain its saturated solution A;

[0075] Take chlorhexidine acetate and add it to trifluoroethanol, fully stir and ultrasonic to dissolve it to obtain its saturated solution B;

[0076] Dissolve polycaprolactone in dichloromethane, stir magnetically at room temperature for 12 hours, and obtain solution C1 with a mass concentration of 6%;

[0077] Dissolve polylactic acid in trifluoroethanol and stir magnetically at room temperature for 12 hours to obtain solution C2 with a mass concentration of 6%;

[0078] Dodecanoic acid and octadecanoic acid were dissolved in a mixed solution of ethanol and dichloromethane with a volume ratio of 2:8 at a mass ratio of 8:2, and ultrasonicated for 10 minutes to obtain a solution F with a mass concentration of 20%;

[0079] Take recombinant human platelet-derived growth factor-BB and add it to sterile ...

Embodiment 2

[0088] To prepare the solution:

[0089] Take metronidazole and add it to trifluoroethanol, fully stir and ultrasonic to make it dissolve to obtain its saturated solution A;

[0090] Take tetracycline hydrochloride and add it to hexafluoroisopropanol, fully stir and ultrasonic to make it dissolve to obtain its saturated solution B;

[0091] Take the mass ratio of polycaprolactone particles and gelatin powder to be 60:40, respectively dissolve them in trifluoroethanol, and stir magnetically at room temperature for 12 hours to obtain a uniform polycaprolactone solution and gelatin solution. Mix the two solutions and stir them for 6 hours. A solution C1 with a mass concentration of 6% is obtained;

[0092] Dissolve polycaprolactone in trifluoroethanol, stir magnetically at room temperature for 12 hours, and obtain solution C2 with a mass concentration of 6%;

[0093] Dodecanoic acid and octadecanoic acid were dissolved in a mixed solution of ethanol and dichloromethane with a v...

Embodiment 3

[0103] To prepare the solution:

[0104] Take metronidazole and add it to N,N-dimethylformamide, fully stir and ultrasonic to dissolve it to obtain its saturated solution A;

[0105] Take chlorhexidine acetate and add it to trifluoroethanol, fully stir and ultrasonic to dissolve it to obtain its saturated solution B;

[0106] Dissolve polycaprolactone in dichloromethane, stir magnetically at room temperature for 12 hours, and obtain solution C1 with a mass concentration of 6%;

[0107] Dissolve polylactic acid in trifluoroethanol and stir magnetically at room temperature for 12 hours to obtain solution C2 with a mass concentration of 6%;

[0108] Dodecanoic acid and octadecanoic acid were dissolved in a mixed solution of ethanol and dichloromethane with a volume ratio of 2:8 at a mass ratio of 8:2, and ultrasonicated for 10 minutes to obtain a solution F with a mass concentration of 20%;

[0109] Take recombinant human platelet-derived growth factor BB and add it to sterile ...

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Abstract

The present invention relates to a fibrous wound repair scaffold loaded with phase change material particles, and a preparation method and application thereof. The invention uses aliphatic polyester, natural macromolecules and phase change materials as main raw materials, adds antibacterial drugs, active substance particles and growth factors, and prepares a multi-layered scaffold with biological activity through electrospinning, electrostatic spraying and the like. The fiber wound repair scaffold provided by the invention adds different kinds of antibacterial drugs to achieve multiple antibacterial effects; contains biologically active substance particles with increased deposition density gradient to promote cell recruitment and migration; contains phase change material particles that promote repair growth factors, To modulate the behavior of different cells by photothermally-triggered controllable delivery of growth factors. The scaffold material provided by the invention has excellent biocompatibility and degradability, can mediate cell migration, proliferation, differentiation and paracrine effect, and can speed up wound repair and improve wound healing effect.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a fiber wound repair scaffold material loaded with phase change material particles and a preparation method and application thereof. Background technique [0002] Due to the increasing incidence of full-thickness skin wounds caused by mechanical injury and burns or diabetes and malignant tumors, the repair of skin wounds has become a major medical problem in the field of wound repair. The “gold standard” of clinical treatment is autologous skin grafting; however, the lack of skin donor sites, secondary injury, and risk of infection limit its application. Therefore, it is urgent to develop artificial wound repair scaffold materials to solve the problems of insufficient autografts. [0003] Currently clinically available scaffold materials mainly play the role of isolation or antibacterial, but their biological activity is low and there is little load of active fact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/32A61L15/44A61L15/46A61L15/62D01D5/00
CPCA61L15/26A61L15/32A61L15/325A61L15/28A61L15/46A61L15/44A61L15/62D01D5/003A61L2300/406A61L2300/404A61L2300/414
Inventor 薛佳佳张馨丹张立群
Owner BEIJING UNIV OF CHEM TECH
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