Continuous array gradient nanofiber bionic stent and preparation method thereof

Abstract

The invention relates to a continuous array gradient nanofiber bionic stent and a preparation method thereof. The method comprises the following steps of: performing electrostatic spinning to obtain an array gradient nanofiber membrane, and performing sterilization and crosslinking treatment to obtain the continuous array gradient nanofiber bionic stent, wherein a receiving device adopted by electrostatic spinning comprises a printed circuit board and an annular electrode; the printed circuit board comprises an insulating substrate and a plurality of bonding pads; the bonding pads are distributed in a way that one bonding pad is distributed in the center of the insulating substrate, and the rest bonding pads form a plurality of annular array bonding pad groups which are distributed circularly; the bottom of the annular electrode is fixed on the insulating substrate; seen from the top of the annular electrode, a circle formed by the inner wall of the annular electrode and circles formed by the annular array bonding pad groups are concentric circles; the circle centers of the concentric circles are the center of the insulating substrate. The stent has a continuous array gradient fiber structure, so that a medicament can be released at the edge and the center of a wound surface at different concentrations.

Description

technical field [0001] The invention belongs to the technical field of bionic supports, and relates to a continuous array gradient nanofiber bionic support and a preparation method thereof. Background technique [0002] The high specific surface area of ​​electrospun nanofibers can improve the interaction between the dressing and the wound microenvironment, and at the same time, its ability to mimic the extracellular matrix makes them promising for wound care, drug delivery, and biotechnology applications. Nanofibrous mats have proven to be ideal for modern effective wound therapy and wound care, and they are efficiently and inexpensively produced during electrospinning, offering multiple highly promising strategies for modern wound therapy. [0003] Studies have shown that by incorporating drugs, growth factors, etc. into dressings, wounds can be healed faster and better, and gradient distribution of bioactive substances plays a vital role in the healing of skin wounds, gra...

AI Technical Summary

Problems solved by technology

[0004] Patent CN107510862B uses electrospinning junction electrode-ring electrode composite receiving device to prepare an ordered fiber scaffold carrying gradient concentration bioactive molecules, but there are few overlapping fibers and less chemokine loading; The interaction between them is weak, the mechanical properties of the scaffold are poor, and the performance of promoting wound healing is not good.

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