A kind of bionic skin dressing with 3D micropattern structure and preparation method thereof
A micro-patterned, 3D technology, applied in the field of biomedical materials and tissue engineering, can solve problems such as blank structures and bionic pathways, achieve good mechanical strength and mechanical properties, protect wounds and wounds, and promote cell adhesion.
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Embodiment 1
[0036] A bionic skin dressing with a straight striped 3D micro-pattern structure, prepared by the following method:
[0037] (1) Prepare a straight stripe micropattern array on a silicon wafer by negative photoresist photolithography, the width of the straight stripes is 50 μm, the spacing is 50 μm, and the depth is 50 μm, and then the polydimethylsiloxane glue is molded on the silicon wafer, After curing in an oven at 80°C for 2 hours, a polydimethylsiloxane glue template with a straight stripe array 3D micropattern structure was prepared;
[0038] (2) 150ml of gelatin solution with a concentration of 10mg / ml, RGD peptide of 0.1mg / ml, and acetone solution with 30ml of triethylamine and 30ml of isocyanoethyl methacrylate dissolved in it were magnetically stirred in an environment of 37°C for 2 Then add the mixed solution into the dialysis bag, place it in the external environment of ultrapure water, change the ultrapure water once every 6 hours, to fully remove the residual or...
Embodiment 2
[0044] A bionic skin dressing with reticular stripe 3D micro-pattern structure is prepared by the following method:
[0045] (1) Prepare a straight stripe micropattern array on a silicon wafer by negative photoresist lithography, the width of the straight stripes is 50 μm, the spacing is 100 μm, and the depth is 40 μm, and then the polydimethylsiloxane glue is molded on the silicon wafer, After curing in an oven at 80°C for 2 hours, a polydimethylsiloxane glue template with a straight stripe array 3D micropattern structure was prepared;
[0046] (2) 150ml of gelatin solution with a concentration of 10mg / ml, RGD peptide of 0.1mg / ml, and acetone solution with 30ml of triethylamine and 30ml of isocyanoethyl methacrylate dissolved in it were magnetically stirred in an environment of 37°C for 2 Then add the mixed solution into the dialysis bag, place it in the external environment of ultrapure water, change the ultrapure water once every 6 hours, fully remove the residual organic s...
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