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Bone defect repair tissue engineering scaffold and preparation method thereof

A technology for tissue engineering scaffolds and bone defects, applied in the field of bone repair, can solve the problems of complex preparation methods of Ti6Al4V scaffolds and the need to improve osseointegration strength, achieve good osteogenic differentiation ability, facilitate large-scale promotion and application, and simple preparation methods Effect

Pending Publication Date: 2021-06-11
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Claims
  • Application Information

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Problems solved by technology

[0005] The preparation method of the Ti6Al4V scaffold provided by the related technology is complicated, and the osseointegration strength between it and the host bone bed needs to be improved

Method used

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  • Bone defect repair tissue engineering scaffold and preparation method thereof
  • Bone defect repair tissue engineering scaffold and preparation method thereof
  • Bone defect repair tissue engineering scaffold and preparation method thereof

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preparation example Construction

[0058] On the other hand, the embodiment of the present invention also provides a preparation method of the above-mentioned tissue engineering scaffold for bone defect repair, the preparation method comprising:

[0059] The metal stent body is aminated by an aminating agent to obtain an aminated stent body.

[0060] The aminated scaffold body is incubated in the cross-linking agent solution for a first set time to obtain a cross-linking group-modified scaffold.

[0061] The scaffold modified by the cross-linking group is immersed in the peptide solution for a second set time to obtain the tissue engineering scaffold for bone defect repair, wherein the peptide solution includes BMSC affinity peptide and BMP-2 mimic peptide.

[0062] In the preparation method of the tissue engineering scaffold for bone defect repair provided by the embodiment of the present invention, first, the metal scaffold body is aminated with an aminating agent to graft ammonium ions on the aminated scaffo...

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Abstract

The invention discloses a bone defect repair tissue engineering stent and a preparation method thereof, and belongs to the field of bone repair. The bone defect repair tissue engineering stent comprises a metal stent body, a BMSC affinity peptide and a BMP-2 mimic peptide, wherein the BMSC affinity peptide and the BMP-2 mimic peptide are grafted on the metal stent body. According to the bone defect repair tissue engineering stent and preparation method thereof of the present invention, the BMSC affinity peptide and the BMP-2 mimic peptide are synchronously bonded to the surface of the metal stent body, such that sufficient BMSC cells can be collected on an interface between a host bone bed and a joint prosthesis surface, the BMSC cells can gain the good osteogenic differentiation ability, and the osseointegration strength between the host bone bed and the joint prosthesis can be significantly improved; the BMSC affinity peptide and the BMP-2 mimic peptide are coupled to the surface of the metal stent body in a chemical grafting mode, so that the preparation method of the engineering stent is simple, and large-scale popularization and application of the engineering stent are facilitated.

Description

technical field [0001] The invention relates to the field of bone repair, in particular to a bone defect repair tissue engineering scaffold and a preparation method thereof. Background technique [0002] Bone and joint replacement is a common bone and joint treatment, for example, revision total hip arthroplasties (RTHA) is often used to treat advanced hip disease, using bone defects to repair tissue engineering scaffolds (also known as joint prostheses) Osseointegration with the host bone bed allows direct bone formation between the host bone bed and the joint prosthesis, so as to achieve the purpose of treatment. [0003] Ti6Al4V alloy has the characteristics of corrosion resistance, high mechanical strength and fracture toughness, and is usually used as a scaffold material. In order to improve the biological function of Ti6Al4V, the related technology uses Ti6Al4V to prepare a gradient 3D printed Ti scaffold with a gradient porous structure by 3D printing technology, for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/06A61L27/22A61L27/54
CPCA61L27/04A61L27/06A61L27/22A61L27/54A61L2430/02A61L2430/24A61L2300/252A61L2300/412A61L2400/18
Inventor 李伟韩晓娟沙丹满振涛徐海伦
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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