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Bionic skin dressing with 3D micropattern structure and preparation method thereof

A micro-patterned, 3D technology, applied in the field of biomedical materials and tissue engineering, can solve problems such as blank structures and bionic pathways, achieve good mechanical strength and mechanical properties, promote tissue repair, and promote cell differentiation.

Active Publication Date: 2018-07-06
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current dressings only promote tissue repair from the composition, while the structure and bionic approaches are still blank

Method used

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  • Bionic skin dressing with 3D micropattern structure and preparation method thereof
  • Bionic skin dressing with 3D micropattern structure and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A bionic skin dressing with a straight striped 3D micro-pattern structure, prepared by the following method:

[0037] (1) Prepare a straight stripe micropattern array on a silicon wafer by negative photoresist photolithography, the width of the straight stripes is 50 μm, the spacing is 50 μm, and the depth is 50 μm, and then the polydimethylsiloxane glue is molded on the silicon wafer, After curing in an oven at 80°C for 2 hours, a polydimethylsiloxane glue template with a straight stripe array 3D micropattern structure was prepared;

[0038] (2) 150ml of gelatin solution with a concentration of 10mg / ml, RGD peptide of 0.1mg / ml, and acetone solution with 30ml of triethylamine and 30ml of isocyanoethyl methacrylate dissolved in it were magnetically stirred in an environment of 37°C for 2 Then add the mixed solution into the dialysis bag, place it in the external environment of ultrapure water, change the ultrapure water once every 6 hours, to fully remove the residual or...

Embodiment 2

[0044] A bionic skin dressing with reticular stripe 3D micro-pattern structure is prepared by the following method:

[0045] (1) Prepare a straight stripe micropattern array on a silicon wafer by negative photoresist lithography, the width of the straight stripes is 50 μm, the spacing is 100 μm, and the depth is 40 μm, and then the polydimethylsiloxane glue is molded on the silicon wafer, After curing in an oven at 80°C for 2 hours, a polydimethylsiloxane glue template with a straight stripe array 3D micropattern structure was prepared;

[0046] (2) 150ml of gelatin solution with a concentration of 10mg / ml, RGD peptide of 0.1mg / ml, and acetone solution with 30ml of triethylamine and 30ml of isocyanoethyl methacrylate dissolved in it were magnetically stirred in an environment of 37°C for 2 Then add the mixed solution into the dialysis bag, place it in the external environment of ultrapure water, change the ultrapure water once every 6 hours, fully remove the residual organic s...

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Abstract

The invention belongs to the field of biomedical materials and tissue engineering, and in particular relates to a bionic skin dressing having a 3D micropattern structure and a preparation method thereof. The biomimetic skin dressing is obtained by curing a polymer composite gel into a composite gel film having a 3D micropattern structure, and then using calcium alginate for high hydrophilic surface treatment. The polymer composite gel is prepared by compounding RGD-peptide-containing methacrylate gelatin and methacrylate hyaluronic acid in a mass ratio of 1:3 to 3:1. The bionic skin dressing having the 3D micropattern structure has a straight stripe groove or a mesh stripe groove array, RGD peptide in the groove array can promote cell adhesion, and the calcium alginate in a convex array structure region can effectively inhibit cell growth, so that cells can selectively grow on the surface of the bionic skin dressing to form the cell micropattern, and the 3D micropattern structure can promote the ability of stem cells to differentiate into fibroblasts and angioblast in vivo and in vitro.

Description

technical field [0001] The invention belongs to the field of biomedical materials and tissue engineering, and in particular relates to a bionic skin dressing with a 3D micro-pattern structure and a preparation method thereof. Background technique [0002] The skin is the largest organ of the mammalian body and serves several critical functions. In some cases, the skin is damaged by trauma (such as a laceration, abrasion, burn, or puncture) or by an ulcer (such as a diabetic foot ulcer), which is called a skin wound. [0003] Dressings refer to dressings, bandages, materials used to cover sores / wounds or other damage (such as ointment, gauze), etc. Traditional dressings are mainly dry gauze and oil gauze, while modern wound dressings include interactive wound dressings, calcium alginate dressings, silver dressings, foam dressings, hydrocolloid dressings, and hydrogel dressings. However, the current dressings only promote tissue repair from the composition, while the structu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0038A61L26/0066A61L26/008A61L2300/30C08L5/08C08L89/00C08L33/10C08L5/04
Inventor 张胜民周璇杨高洁
Owner HUAZHONG UNIV OF SCI & TECH
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