51results about How to "Speed ​​up wound healing" patented technology

The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications. Aspects of the invention provide nucleic acid molecules for the prophylactic treatment of wounding to reduce scarring. Herein, it is demonstrated that a specific nucleic acid molecule, RXI-109 (targeting connective tissue growth factor (CTGF)), given prophylactically, reduces scarring during wound healing.

Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing αv integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing αv integrins.

The invention discloses an acne removing and antiallergic cream which is prepared by mixing stearyl alcohol polyether-2, stearyl alcohol polyether-20, glycerin stearate, PEG (Polyethylene Glycol)-100 stearate, stearic acid, cetearyl alcohol, aloe oil, polydimethyl siloxane, isopropyl myristate, propyl p-hydroxybenzoate, methyl p-hydroxybenzene, tocopherol, azone, bisabolol, glycerol, xanthan gum, EDTA (Ethylene Diamine Tetraacetic Acid)-2Na, propylene glycol, ethanol, menthol, salicylic acid, a golden cypress extractive, a scutellaria baicalensis extractive, an India chinaberry leaf extractive, a spiraea ulmaria extractive, a bee milk extractive, an aloe leaf extractive, tea tree oil and sodium hydroxide. The acne removing and antiallergic cream disclosed by the invention can be used for removing acnes, promoting the facial blood circulation and skin cell regeneration, improving the skin tolerance and reducing or eliminating the allergic reaction of the skin; the allergic tolerance of the skin is improved, so that the cream is safe and effective; no any spices are added, so that allergens are greatly reduced.

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated CAR peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

The invention relates to an alginate dressing for treating bedsore and a preparing method thereof. The dressing has a double-layer composite structure, namely the dressing comprises a base layer and a surface layer. The base layer is an alginate composite film layer. The surface layer is a natural rubber film layer. The preparing method includes following steps of: A) preparing a shark collagen solution, B) preparing a coaxial electrospinning outer layer solution, C) preparing a coaxial electrospinning core layer solution, D) spinning, E) crosslinking, F) dipping, G) preparing an epoxy natural rubber film, and H) compositing. The dressing has good biocompatibility, and has controllable growth regulation, good hygroscopicity, good anti-inflammation performance and good antibacterial performance of synthetic biological materials. The dressing is capable of improving local blood supply of wounds, promoting tissue growth and accelerating wound healing, shows good multifunctional properties, has good porosity, soft and comfort hand feeling, good compliance and using convenience, and can be used in the field of modern biomedicine, especially in the field of bedsore treatment and nursing, and the like.

The invention belongs to the field of biological medicine, and particularly relates to composite hydrogel for promoting wound healing as well as a preparation method and application thereof. The composite hydrogel is composed of gelatin, antibacterial photodynamic peptide and recombinant human III-type collagen. A photosensitizer Ce6 is introduced for photodynamic antibacterial chemotherapy antibiosis, and the photosensitizer Ce6 generates active oxygen under laser irradiation to cause microbial molecule oxidation and bacterial cell damage and death, so that the photosensitizer Ce6 and antibacterial peptide generate a synergistic effect. The antibacterial composite hydrogel has high biocompatibility, keeps a wet environment around a wound surface, can stably convey loaded antibacterial photodynamic peptide and recombinant human collagen to the surface of the wound, guides fibroblasts to migrate and proliferate and increases deposition of new collagen on blood vessels for reconstructionin a dermal repair process, thereby accelerating wound healing, thereby improving wound healing quality.

The invention relates to a medicinal chitosan dressing which comprises the constituents of (by weight parts) chitosan 5-10, polyvinyl alcohol 6-15, gelatin 5-10, glycerol 10-20, water 45-75, and the preparing process consists of swelling with water, dissolving through water-bath, mixing solutions homogenously, adjusting pH to 4-7, filtering and removing foams.

A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. In some versions, the antioxidant agent is α-tocopherol or N-acetyl cysteine, or a combination of these compounds.

The invention discloses an emodin succinyl ester type compound as well as a preparation method and application thereof. The compound disclosed by the invention has a structure shown as a formula I (wherein, R is C1 to C5 alkyl); preferably, the compound is emodin succinyl ethyl ester. An experiment proves that the emodin succinyl ester type compound disclosed by the invention can be used for promoting the healing of diabetes mellitus wounds better when being compared with emodin, and can be used for preparing a medicine for promoting the healing of the diabetes mellitus wounds. Furthermore, the invention further discloses a method for preparing the compound; the method has a simple route, can effectively shorten the synthesis time and reduce the cost, is simple to operate and easy to implement, so that the method is suitable for industrial production. (The formula I is shown in the description.).

The invention relates to a method for raising seedlings of tomatoes through grafting. The method comprises the following steps: S1, selection of rootstocks; S2, preparation of a substrate; S3, cultivation of the rootstocks and scions: (1) determining a sowing date; (2) soaking seeds, and performing germination; and (3) performing sowing; S4, management after sowing is conducted: (1) performing rootstock management; and (2) performing scion management; S5, grafting: (1) performing preparation before grafting is conducted; and (2) determining a cutting grafting method; and S6, management after grafting is conducted: (1) performing heat preservation; (2) performing moisture preservation; (3) performing shading; (4) removing lateral buds; (5) performing management after survival is achieved; and (6) controlling diseases and pests. The method has the advantages that the grafting efficiency can be improved, the healing speed of wounds of the rootstocks and the scions is accelerated, and a high survival rate of the grafted seedlings, high disease resistance and good quality of the grafted seedling products are achieved; and the method is particularly suitable for tomato seedling graftingcultivation in scorching heat, high temperature, exposure to the sun and other harsh environments in summer.

The invention relates to an absorbable growth factor composite dressing which is mainly prepared from compound cellulose and growth factors, wherein the compound cellulose is prepared by compounding modified hydroxyethylcellulose and sodium alga acid. The dressing is prepared by compounding the modified hydroxyethylcellulose and the sodium alga acid to prepare the compound cellulose and then adding 0.02-0.05% of freeze-dried growth factor powder, and evenly mixing the compound cellulose with the powder. The dressing can promote rapid wound healing, shorten the treatment period and can be widely applied to various wounds comprising internal wounds and external wounds.

The invention provides application of cyclic dipeptide in preparation of drugs for treating skin injury. The cyclic dipeptide is cyclo-L-prolyl-L-dipeptide, and is particularly used for burns and scalds. The dipeptide has the features of small molecular weight, simple structure and the like. The cyclic dipeptide has a remarkable effect on treatment of burns and scalds, can quickly permeate injured skin tissues and enter cells in a treatment process, repairs injured cells and activates self-repairing capability, wound healing speed is accelerated, recurrence rate is low after healing, scars are shallow, and potential side effects after treatment by traditional Chinese medicines and western drugs are avoided. Moreover, the cyclic dipeptide also has effects of inhibiting inflammation and stopping pain, and improving immunity.

A method for treating or preventing oral cavity mucosal disorders, comprising a step of providing a lozenge containing an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and other ingredients and a step of placing the lozenge within the oral cavity for a period of time required for dissolution of the lozenge.

The invention relates to antibacterial hydrocolloid and a preparation method of the antibacterial hydrocolloid and belongs to the technical field of medicine. Through the fiber superfine pulverization technology, hydroxypropyl trimethylammonium chloride chitosan fiber with high antibacterial performance is processed into superfine powder bodies with the average particle diameter being 1 to 5mum, the superfine powder bodies, hot sol substances, moisture absorption macromolecules and tackifiers are sequentially added in different process stages, and the hydrocolloid is formed, so the potential biosafety risk caused by the use of nanometer metal as antibacterial agents is avoided. The traditional preparation process of the hydrocolloid is changed through the preparation method of the antibacterial hydrocolloid provided by the invention. When the antibacterial hydrocolloid prepared by the invention acts on wound, bacteria on the surfaces of the chronic wound can be killed, the wound infection can be prevented, meanwhile, a large amount of wound transudate can be absorbed, micro gel is formed after the transudate absorption, the humid environment is provided for the wound, and the wound healing is promoted.

The invention relates to the field of skin repair, and discloses a skin repair composition and a preparation method thereof. The skin repair composition is prepared from four active ingredients including collagen, Ectoine, polyhydric alcohol and a liquorice root extract. The prepared dressing has the effects of promoting wound healing, inhibiting bacteria, stopping bleeding, diminishing swelling and resisting inflammation. Compared with other similar products on the market, the product not only improves the wound healing speed and effectively repairs the skin barrier function injury, but also remarkably improves uncomfortable symptoms such as skin itch, scorching hot, skin tension and pain and reduces the risk of hyperpigmentation and scar formation after inflammation. The product is remarkable in curative effect, and can be produced on a large scale to meet the market requirements.

The invention discloses special fertilizer for water grass for rice-fish complex planting and breeding. The special fertilizer is prepared from the following raw material components in parts by weight: 20 to 30 parts of potassium sulfate type slow release fertilizer, 8 to 24 parts of humic acid, 18 to 25 parts of ammonium sulfate, 15 to 20 parts of calcium magnesium phosphate fertilizer, 4 to 8 parts of diaminoferric xanthohumate, 6 to 12 parts of attapulgite, and 6 to 10 parts of composite root growth promoting agent. According to the special fertilizer for the water grass for rice-fish complex planting and breeding provided by the invention, growth characteristics and fertilizer requirement laws of the water grass for rice-fish complex planting and breeding are combined, so that accuratenutrition is provided for the water grass, the water grass can quickly grow roots and grow continuously and are promoted to grow new roots and grow new buds, the water grass is developed in root systems and robust in stems, a soil holding force of the water grass is improved, the root amount is increased, the root taking vitality of the water grass is improved, the resistance of the water grass can be also improved, and the requirements of a rice-fish industry on the water grass are met.

Compositions and methods are provided for the prevention and treatment of chronic wounds such as pressure ulcers by transdermal delivery of an agent that increases activity of HIF-1alpha in the wound. Wound healing ability reduced in aged subjects can be restored by use of the iron chelator formulations and methods to be similar to that of young subjects.

The invention discloses a skin wound caring composition, a caring agent and a preparation method. The skin wound caring composition comprises the following raw materials in parts by weight: 2-20 partsof ethanol, 1-10 parts of aloe vera gel, 0.5-5 parts of propolis and 2-20 parts of mint oil. The skin wound caring agent comprises the skin wound caring composition. Compared with the prior art, theskin wound caring composition has the benefits as follows: the ethanol and the propolis in the skin wound caring composition have sterilization and anti-inflammatory functions and have heat clearing and pain relieving functions under assistance of mint oil, the aloe vera gel is used, so that the skin wound caring composition has the advantages of increasing skin wound healing speed and reducing bacterial infection risk of skin wounds. Meanwhile, the wound caring composition is simple in formula and low in cost.

The invention discloses application of FG-4592 to promotion of epidermal stem cell migration. On the basis of the FG-4592 structure and performances and specific administration route, dosage and administration frequency / time, epidermal stem cell migration can be effectively promoted by the FG-4592. According to researches, the FG-4592 is capable of promoting epidermal stem cell movement, remarkably increasing epidermal stem cell movement rate, promoting epidermal stem cell proliferation and improving epidermal stem cell proliferation activity, and a basis is provided for regulating epidermal stem cell migration to further regulate epidermal stem cell culture, epidermic grafting and wound healing. The FG-4592 can be applied to preparation of epidermal stem cell culture solution and auxiliary medicines for epidermic grafting and wound healing and brings good to patients suffering from burns, pressure sores, varicose ulcer of lower extremities and diabetic feet and patients with chronic and refractory wounds after skin flap transplantation and epidermic grafting, and a promising application and market prospect is achieved.

A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. in some versions, the antioxidant agent is α-tocopherol or N-acetyl cysteine, or a combination of these compounds. In other versions, a method of preparing a chronic wound animal model is provided.

The invention relates to the field of biological medicines and daily necessities, and specifically relates to tissue repair protein CHRD, and a coding gene and applications thereof. The protein is shown as the following a1 or a2: a1, the protein whose amino acid sequence is shown as a sequence 1 in a sequence table; and a2, the protein formed through the substitution and / or deletion and / or addition of one or several amino acid residues to the amino acid sequence shown as the sequence 1 in the sequence table and related to the repairing of skin wounds. Through the proving of experiments, the CHRD protein has significant repair effects on simple skin wound repair and wounds with radiation and skin damage; and compared with sterile medical gauze, the CHRD protein can make the healing speed ofthe wounds with radiation and skin damage accelerated about 30%.

The invention discloses a medical composition. The medical composition is a preparation prepared from the following components in parts by weight: 10 to 100 parts of nano-silver, 30 to 80 parts of hydrolyzed collagen, 10 to 50 parts of bletilla striata gelatin and 0.5 to 3 parts of asiaticoside. The invention further discloses a preparation method and application of the medical composition. The medical composition disclosed by the invention can be used for rapidly reducing a wound area of damaged skin, remarkably shortening scabbing, scab falling and wound healing time and accelerating skin wound healing speed; the medical composition can be used for effectively repairing the damaged skin and has relatively strong actual application value.

Disclosed are compositions and methods useful for targeting molecules to activated macrophages, such as tumor associated macrophages. The compositions and methods are based on peptide sequences, such as AMT peptides, that home to activated macrophages. The disclosed homing to activated macrophages is useful for delivering therapeutic and detectable agents to cells and tissues where immune system effects or inflammation are occurring.

The invention relates to a traditional Chinese medicine composition for treating gynecological postoperative pain and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials: 15 to 25 parts of caulis sargentodoxae, 10 to 20 parts of giant knotweed, 10 to 20 parts of carthamus tinctorius, 25 to 35 parts of herba lycopi, 15 to 25 parts of corydalis tuber, 10 to 20 parts of szechuan lovage rhizome, 5 to 15 parts of radix salviae miltiorrhizae, 5 to 15 parts of cortex moutan radicis, 10 to 20 parts of radix dipsaci, 10 to 20 parts of radix gentianae macrophyllae, and 5 to 15 parts of cattail pollen. The preparation method comprises the following steps: smashing the raw materials, mixing the smashed raw materials, adding water into the mixture, carrying out decocting for two times, filtering the liquid, combining the filtrate, carrying out concentration till the concentrated liquid is 1 / 2 of the original filtrate in volume to obtain a concentrated solution, concentrating the concentrated solution into thick extract of which the relative density is 1.20 to 1.24 (the measuring temperature is 80 DEG C), putting the thick extract into a drying oven for 50 to 70 DEG C drying till the water content is lower than 5 percent; adding auxiliary materials; preparing capsules, tablets, granules or enteric-coated tablets according to the conventional technology in the field.

The invention discloses a planting method of purple rice rich in trace elements such as zinc, selenium and titanium. The method includes the following steps: selecting varieties: selecting conventional high-yield purple rice with long growth period, strong heat resistance, wide adaptability, good disease resistance and stability. According to the method, starting from seed soaking, the seed matrixabsorbs trace elements such as zinc, selenium, titanium and the like, and a Yunlong No.1 agent containing zinc, selenium, titanium and other trace elements is sprayed 5 times in the whole process, sothat the purple rice crops can fully absorb nutrition and dimensionless elements, and pesticides and other agents are not required to prevent insects and diseases; and in addition, Yunlong bio-organic bacteria have sufficient fertilizer strength, are made of pure natural materials, are safe and pollution-free, only need to be applied once in the whole process, and the dosage tends to decrease year by year, so that the method is beneficial to saving the cost.

The invention discloses pectin repair gel and a preparation method thereof. The pectin repair gel is prepared from the following components in percentage by weight: 2-20% of pectin, 0.5-0.8% of organic calcium, 0.5-0.8% of a PVM / MA decadiene cross-linked polymer, 1.5-2% of chitosan, and the balance of water. According to the pectin repair gel and the preparation method, the deficiencies in the prior art are overcome; the moisturizing effect is good; the wound healing speed is increased; calcium ions are supplemented while water is supplemented for the skin; the repair of a skin barrier function is accelerated; and the pectin repair gel can be applied to daily accidental skin injury for controlling inflammation, so that secondary skin injury is reduced.

The invention relates to antibacterial hydrocolloid and a preparation method of the antibacterial hydrocolloid and belongs to the technical field of medicine. Through the fiber superfine pulverization technology, hydroxypropyl trimethylammonium chloride chitosan fiber with high antibacterial performance is processed into superfine powder bodies with the average particle diameter being 1 to 5mum, the superfine powder bodies, hot sol substances, moisture absorption macromolecules and tackifiers are sequentially added in different process stages, and the hydrocolloid is formed, so the potential biosafety risk caused by the use of nanometer metal as antibacterial agents is avoided. The traditional preparation process of the hydrocolloid is changed through the preparation method of the antibacterial hydrocolloid provided by the invention. When the antibacterial hydrocolloid prepared by the invention acts on wound, bacteria on the surfaces of the chronic wound can be killed, the wound infection can be prevented, meanwhile, a large amount of wound transudate can be absorbed, micro gel is formed after the transudate absorption, the humid environment is provided for the wound, and the wound healing is promoted.

The invention relates to a medical chitosan dressing, which is composed of chitosan, polyvinyl alcohol, gelatin and glycerin. The above-mentioned components are calculated in parts by weight: chitosan: 5-10, polyvinyl alcohol: 6-15, Gelatin: 5-10, glycerin: 10-20, water 45-75, fully swell polyvinyl alcohol and gelatin with water, then dissolve in a water bath, dissolve chitosan in glycerin aqueous solution, mix the two solutions together and stir well , adjust the pH value to 4-7, filter and defoam to obtain a medical chitosan dressing. The invention satisfies the moist requirement of the wound surface, absorbs infiltration without forming effusion with the wound surface, and re-forms a film after the wound surface dissolves, so as to provide an ideal healing environment and platform for the wound surface.