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Use of apc analogue for wound healing

a technology of wound healing and analogues, applied in the field of wound repair and healing, can solve the problems of increasing the likelihood of chronic wound formation, increasing the degree of fibrosis and scar formation, and chronic inflammation, and achieve the effect of accelerating the rate of wound healing, and decreasing the wound area or volume of the dermal wound

Inactive Publication Date: 2018-08-30
ZZ BIOTECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

APC-3K3A effectively accelerates wound healing, reduces wound area, and minimizes inflammation, demonstrating improved wound repair outcomes compared to APC, even in the absence of significant apoptosis, and is suitable for both acute and chronic wounds.

Problems solved by technology

A protraction of the wound repair process beyond this time increases the likelihood of formation of a chronic wound.
In particular it has been observed that an absence of inflammation in wound healing is linked with regeneration, whereas presence of inflammation results in some degree of fibrosis and scar formation.
Further, extended inflammation can lead to chronic inflammation, and insofar as cutaneous wounds are concerned, a failure for a wound to properly close, and ulceration.

Method used

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  • Use of apc analogue for wound healing
  • Use of apc analogue for wound healing
  • Use of apc analogue for wound healing

Examples

Experimental program
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Effect test

examples

Example 1 APC-3K3A Promotes Wound Repair in an In Vivo Excisional Model

[0075]Materials & Methods

[0076]C57BL / 6J mice were at 7-8 weeks of age when starting wounding protocol. Mice were obtained from and housed at Kearns Facility, Kolling Medical Research Institute, under a 12 h light / 12 h dark cycle at 22° C.

[0077]Full-thickness skin wounds were made using an iris scissor and a sterile 6-mm punch biopsy tool was used to outline a pattern on the dorsum of the mice.

[0078]Recombinant (r)3K3A-APC, rAPC or phosphate buffered saline (PBS) control was injected into the skin at 4 points, each receiving 10 μl, around the internal periphery of the wounds, and 10 μl added topically to the wound, once a day for the first three consecutive days.

[0079]The animals were then kept under anaesthesia for 15 minutes to allow absorption of the solution. The wounds were left open and the animals were housed in individual cages.

[0080]Wound healing was monitored by taking digital photographs and blindly mea...

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Abstract

The invention relates to wound repair and healing, particularly to dermal or cutaneous wounds including but not limited to acute and chronic wounds, burns and ulcers.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 15 / 304,433, filed Oct. 14, 2016, which is a filing under 35 U.S.C. 371 of PCT / AU2015 / 050177, filed Apr. 16, 2015, which claims priority from Australian Patent Application No. 2014902900, filed Jul. 25, 2014, and Australian Patent Application No. 2014901397, filed Apr. 16, 2014. These prior applications are incorporated herein by reference in their entirety.FIELD OF THE INVENTION[0002]The invention relates to wound repair and healing, particularly to dermal or cutaneous wounds including but not limited to acute and chronic wounds, burns and ulcers.BACKGROUND OF THE INVENTION[0003]Reference to any prior art in the specification is not an acknowledgment or suggestion that this prior art forms part of the common general knowledge in any jurisdiction or that this prior art could reasonably be expected to be understood, regarded as relevant, and / or combined with other pieces of pri...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/48A61K9/00A61L26/00
CPCC12Y304/21069A61K9/0019A61L2300/252A61K38/4866A61L26/0076A61L26/0066A61K9/0014A61L26/008A61P17/02
Inventor XUE, MEILANGJACKSON, CHRISTOPHER JOHN
Owner ZZ BIOTECH LLC
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