Wound healing

a wound and wound technology, applied in the field of wounds, can solve the problems of critical evidence of causality already lost, difficulty in human tissue collection, etc., and achieve the effects of improving the re-epithelialization of wounds, reducing wound infection, and increasing wound healing ra

Inactive Publication Date: 2016-11-24
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]In one aspect, a method of treating a wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. In some embodiments: a) the at least one antioxidant agent decreases wound infection; b) the at least one antioxidant agent increases the rate of wound healing; c) the at least one antioxidant agent is two or more antioxidant agents; d) the at least one antioxidant agent comprises a free radical scavenger, a lipid peroxidation inhibitor, or a combination thereof; e) the at least one antioxidant agent comprises N-acetyl cysteine, vitamin A, vitamin C, vitamin E, α-tocopherol, glutathione, lipoic acid, carotenes, coenzyme Q (ubiquinol), melatonin, ellagic acid, punicic acid, luteolin, catalase, superoxide dismutase, peroxiredoxins, cystei

Problems solved by technology

Challenges in doing research and understanding these problematic wounds result from varying disease etiologies, existing co-morbidities and, importantly difficulties with human

Method used

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Examples

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example 1

[0047]The methods in this Example were described in Sandeep Dhall, Danh C. Do, Monika Garcia, et al., “Generating and Reversing Chronic Wounds in Diabetic Mice by Manipulating Wound Redox Parameters,” Journal of Diabetes Research, vol. 2014, Article ID 562625, 18 pages, 2014. doi:10.1155 / 2014 / 562625, incorporated by reference herein.

Dermal Excision Wound Model, Preparation of Tissue for Extracts and for Histology

[0048]The surgical procedures discussed here were approved by the Institutional Animal Care and Use Committee of the University of California, Riverside. Buprenex and ATZ are administered 30 and 20 minutes before surgery, respectively. The mouse is then placed in an enclosed container that is hooked up to a isoflurane vaporizer in the chemical hood. Once the mouse is knocked out or no longer moving, it is placed on a white surgical pad and the head is fitted with a nose cone that is secured to allow continuous administration of isoflurane for the duration of the surgery. A w...

example 2

[0062]This Example shows whether early reduction in the antioxidant capacity immediately after wounding leads to the development of chronic wounds and whether application of antioxidants to these chronic ulcers reduces the oxidative stress and leads to restoration of normal healing.

I. Excessive Redox Environment in Impaired Wounds of the Diabetic Mouse Model, db / db− / −, Mimics the Environment Present in Human Chronic Wounds

[0063]Understanding how wounds become chronic will provide insights to reverse chronicity. We hypothesized that the high levels of oxidative stress (OS) in wound tissue is a critical component for generation of chronicity. To test this possibility we used the db / db− / − model of impaired healing and tested for key molecules involved in oxidative stress during wound healing (data are shown in the Figures). FIG. 1 shows a simplified version of the ROS / NOS cycle. We examined the levels of the molecules depicted in the boxes (FIG. 2). As early as 4 hrs after wounding, we...

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Abstract

A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. In some versions, the antioxidant agent is α-tocopherol or N-acetyl cysteine, or a combination of these compounds.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of Provisional Patent Application No. 62 / 165,156, filed on May 21, 2015, which is incorporated by reference herein.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]This invention was made in part with Government support under Grant No. R21A1078208 from the National Institutes of Health, National Institute of Allergy and Infectious Diseases. The Government has certain rights in this invention.BACKGROUND[0003]1. Field of the Invention[0004]The invention relates to creating and treating wounds.[0005]2. Related Art[0006]Wound healing is a dynamic process involving many factors and cell types including soluble mediators, blood cells, fibroblasts, endothelial cells, and extracellular matrix. Normal wound healing is divided into several sequential phases that overlap in space and time: homeostasis, inflammation, granulation tissue formation, and tissue remodeling. Chronic wounds develop as ...

Claims

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Application Information

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IPC IPC(8): A61K31/355A61K9/00A61K31/198
CPCA61K31/355A61K9/0014A61K31/198A61K45/06A61L15/44A61L26/0066A61L2300/412A61K2300/00
Inventor MARTINS-GREEN, MANUELADHALLI, SANDEEPDO, DANHSCHILLER, NEAL
Owner RGT UNIV OF CALIFORNIA
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