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Application of cyclic dipeptide in preparation of drugs for treating skin injury

A technology of skin trauma and cyclic dipeptide, which is applied in the application field of cyclic dipeptide, can solve the problems of poor penetration of necrotic tissue, damage of cell activity, and influence on appearance, etc., so as to improve the body's immune function, speed up healing, and simple structure Effect

Inactive Publication Date: 2016-02-03
陈光健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine prescriptions are made from Chinese herbal medicines through certain process steps, but there are other ingredients in Chinese herbal medicines besides the active ingredients. After treating burn and scald wounds with external preparations of traditional Chinese medicine, a large amount of pigment is deposited, which makes the scars more obvious after wound healing and affects the appearance
Western medicine is mainly based on anti-inflammatory and symptomatic treatment, and has relatively large side effects during the treatment process. For example, although the antibacterial effect of silver sulfadiazine has a significant effect on controlling wound infection, it has a certain damage to the activity of cells and has a certain effect on the penetration of necrotic tissue. poor sex

Method used

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  • Application of cyclic dipeptide in preparation of drugs for treating skin injury
  • Application of cyclic dipeptide in preparation of drugs for treating skin injury
  • Application of cyclic dipeptide in preparation of drugs for treating skin injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 The preparation method of ring-L-pro-L-propanedipeptide described in the present invention

[0020] Main pharmaceutical reagents: L-alanine, proline protected by Boc amino group

[0021] The process of preparing cyclo-L-pro-L-propane dipeptide:

[0022] (1) Preparation of alanine methyl ester hydrochloride: Add 10 g of L-alanine to a mixture of an appropriate amount of methanol and thionyl chloride, and stir at room temperature for 24 hours. TLC traced the completion of the reaction, and the solvent was spin-dried under reduced pressure to obtain 14.78 g of white alanine methyl ester hydrochloride.

[0023] (2) Neutralization and condensation reaction: Add alanine methyl ester hydrochloride obtained in step (1), 20 g of proline protected by Boc amino group, 20 ml of pyridine, and DMAP into 100 ml of anhydrous tetrahydrofuran, and wait until all are mixed , under the protection of argon, add (Boc) dissolved in anhydrous tetrahydrofuran 2 O, stirred at roo...

Embodiment 2

[0026] Application of embodiment 2 ring-L-pro-L-propanedipeptide in burns and scalds

[0027] The purpose of this example is to further illustrate the application of the cyclo-L-pro-L-propane dipeptide described in the present invention in the preparation of medicines for treating burns and scalds with the results of experimental burns in mice.

[0028] 1. Experimental materials

[0029] 1.1 Sample: Sample obtained according to Example 1: cyclo-L-pro-L-propanedipeptide

[0030] 1.2 Experimental animals: 180 healthy Kunming mice of 18-22g

[0031] 1.3 Experimental reagents: 10% sodium sulfide solution, ether, moist burn ointment (Shantou Meibao Pharmaceutical Co., Ltd.)

[0032] 2. Evaluation method for the functional effect of Cyclic-L-proline-L-propanedipeptide on burns and scalds in mice

[0033] 2.1 Effects on Experimental Scalding of Mice

[0034] 30 healthy Kunming mice were randomly divided into 3 groups, 10 in each group. The hair on the back of the mice was removed...

Embodiment 3

[0045] Example 3 Cyclic-L-pro-L-propanedipeptide regulates the immune function of the body

[0046] The purpose of this example is to further illustrate the role of the cyclo-L-pro-L-propanedipeptide described in the present invention in regulating the immune function of the body.

[0047] 1. Experimental materials

[0048] Sample: The sample prepared in Example 1: cyclo-L-pro-L-propane dipeptide.

[0049] Experimental animals: male BALB / C mice with a mass of 18-22g SPF

[0050] experimental method:

[0051] The mice were randomly divided into normal group, model group, positive group and cyclo-L-pro-L-propanedipeptide dosage group, with 10 mice in each group. The samples were made into 0.5mg / ml test solution and then administered to the mice. The normal group and the model group were given the same amount of normal saline, and the positive group was given astragalus essence at 20mL / kg, ig once a day for 14 consecutive days. On the 1st, 2nd, 3rd, 8th, 9th, and 10th days of...

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Abstract

The invention provides application of cyclic dipeptide in preparation of drugs for treating skin injury. The cyclic dipeptide is cyclo-L-prolyl-L-dipeptide, and is particularly used for burns and scalds. The dipeptide has the features of small molecular weight, simple structure and the like. The cyclic dipeptide has a remarkable effect on treatment of burns and scalds, can quickly permeate injured skin tissues and enter cells in a treatment process, repairs injured cells and activates self-repairing capability, wound healing speed is accelerated, recurrence rate is low after healing, scars are shallow, and potential side effects after treatment by traditional Chinese medicines and western drugs are avoided. Moreover, the cyclic dipeptide also has effects of inhibiting inflammation and stopping pain, and improving immunity.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of a cyclic dipeptide. Background technique [0002] Skin trauma is a common disease in people's daily production and life. If it is not treated in time, it will lead to infection, suppuration, scarring, and even systemic sepsis, which is life-threatening. [0003] Burns and scalds are common body injuries in wartime and daily life. With the development of modern industrial and agricultural production technology, chemical and electronic burns are also increasing. In disasters such as forest fires, flammable and explosive materials burning and explosions, and fires in public places, it is very likely that a large number of people will be burned and scalded. [0004] The pathological changes of the local tissues of deep burns are divided into three zones similar to concentric circles according to the different levels of local damage, namely: 1. The center is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61P17/02
Inventor 陈光健
Owner 陈光健
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