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Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid

A hydrocolloid and antibacterial water technology, applied in the field of medicine, can solve the problems of unclear negative biological effects and adverse reactions, application restrictions, etc., and achieve the effects of avoiding biological safety risks, preventing wound infection, and reducing pain.

Inactive Publication Date: 2012-10-10
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the clinical application of nano-silver-containing hydrocolloid dressings is greatly limited due to the negative biological effects and adverse reactions caused by the migration of nano-sized silver particles into the human body.

Method used

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  • Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid
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  • Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid

Examples

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preparation example Construction

[0032] Preparation of a hydroxypropyltrimethylammonium chloride chitosan fiber

[0033] Disperse chitosan fibers in isopropanol at a mass volume ratio of 1:20, and then add 2,3-epoxypropyl trimethyl chloride at a molar ratio of glucosamine residues of chitosan fibers of 1:4 ammonium, moved into a shaker, and oscillated evenly at room temperature to obtain a solid-liquid mixture of chitosan fibers. In the solid-liquid mixture of chitosan fibers, a sodium hydroxide solution with a concentration of 20wt% was added according to the chitosan fiber mass-volume ratio of 1:2. Shake the chitosan fiber reaction mixture evenly to obtain the chitosan fiber reaction mixture. After reacting the chitosan fiber reaction mixture in a constant temperature water bath at 90°C for 6.0 hours, separate the reacted chitosan fiber and wash it with 80v% ethanol aqueous solution and absolute ethanol in sequence. 2 times, the washed chitosan fibers were dried at 40°C to obtain hydroxypropyltrimethylammon...

Embodiment 1

[0048] Preparation of a hydroxypropyltrimethylammonium chloride chitosan fiber

[0049] Weigh 50g of chitosan fiber and disperse it in 1000mL of methanol, add 188g of 2,3-epoxypropyltrimethylammonium chloride, move it into a shaker, oscillate evenly at room temperature, then add 100g of NaOH solution with a concentration of 20wt%, Oscillate evenly at room temperature, react in a constant temperature water bath at 90°C for 6.0 hours, separate the reacted chitosan fibers, and wash them twice with 80v% ethanol aqueous solution and absolute ethanol in turn, and the washed chitosan fibers are at 40 drying under the condition of ℃ to obtain hydroxypropyltrimethylammonium chloride chitosan fiber with a substitution degree of 85%.

[0050] Preparation of b hydroxypropyl trimethyl ammonium chloride chitosan fiber powder

[0051] Weigh 50g of hydroxypropyltrimethylammonium chloride chitosan fiber and cut it into short fibers of 3mm with a fiber grinder, then process the short fibers in...

Embodiment 2

[0056] Preparation of a hydroxypropyltrimethylammonium chloride chitosan fiber

[0057] Weigh 50g of chitosan fiber and disperse it in 1000mL of methanol, add 188g of 2,3-epoxypropyltrimethylammonium chloride, move it into a shaker, oscillate evenly at room temperature, then add 100g of NaOH solution with a concentration of 20wt%, Oscillate evenly at room temperature, react in a constant temperature water bath at 90°C for 6.0 hours, separate the reacted chitosan fibers, and wash them twice with 80v% ethanol aqueous solution and absolute ethanol in turn, and the washed chitosan fibers are at 40 drying under the condition of ℃ to obtain hydroxypropyltrimethylammonium chloride chitosan fiber with a substitution degree of 85%.

[0058] Preparation of b hydroxypropyl trimethyl ammonium chloride chitosan fiber powder

[0059] Weigh 50g of hydroxypropyltrimethylammonium chloride chitosan fiber and cut it into short fibers of 4mm with a fiber grinder, then process the short fibers in...

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Abstract

The invention relates to antibacterial hydrocolloid and a preparation method of the antibacterial hydrocolloid and belongs to the technical field of medicine. Through the fiber superfine pulverization technology, hydroxypropyl trimethylammonium chloride chitosan fiber with high antibacterial performance is processed into superfine powder bodies with the average particle diameter being 1 to 5mum, the superfine powder bodies, hot sol substances, moisture absorption macromolecules and tackifiers are sequentially added in different process stages, and the hydrocolloid is formed, so the potential biosafety risk caused by the use of nanometer metal as antibacterial agents is avoided. The traditional preparation process of the hydrocolloid is changed through the preparation method of the antibacterial hydrocolloid provided by the invention. When the antibacterial hydrocolloid prepared by the invention acts on wound, bacteria on the surfaces of the chronic wound can be killed, the wound infection can be prevented, meanwhile, a large amount of wound transudate can be absorbed, micro gel is formed after the transudate absorption, the humid environment is provided for the wound, and the wound healing is promoted.

Description

technical field [0001] The invention relates to an antibacterial hydrocolloid and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Chronic wounds are skin tissue damages caused by external force factors such as surgery and heat. Often the healing process is partially or completely stopped due to infection and other reasons, making the healing time of the wounds more than 2 weeks. If not treated in time, It is easy to cause the deterioration of the primary disease and even endanger the life of the patient. Clinically, hydrocolloid dressings are generally used to treat wounds after debridement. After contacting with wound exudate, the dressing can absorb the exudate and form a gel to provide a moist environment for the wound, thereby promoting wound healing. However, due to the lack of antibacterial properties of this hydrocolloid dressing, the effect is often unsatisfactory when dealing with chronic wounds, especially...

Claims

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Application Information

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IPC IPC(8): A61L15/34A61L15/28A61L15/24A61L15/42C08L53/02C08L5/08C08L23/20C08L23/16C08K5/103C08K5/39C08B37/08
Inventor 周应山徐卫林
Owner WUHAN TEXTILE UNIV
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