Biodegradable Metal Vascular Stents

A vascular stent and biodegradable technology, applied in the field of metal stents and human vascular stents, can solve problems such as excessive corrosion, loss of stent integrity, and failure to achieve expected results, improve mechanical properties and corrosion resistance, avoid Biosafety risk, effect of slowing down the rate of degradation

Inactive Publication Date: 2019-12-27
青岛市即墨区人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Corrosion too fast in body fluids and insufficient mechanical strength are the two main disadvantages of pure magnesium
Corrosion is too fast, on the one hand, the hydrogen, magnesium ions, and hydroxide ions generated by degradation will have a toxic effect on the human body; on the other hand, the stent will lose its integrity in a short period of time, failing to achieve the expected effect

Method used

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  • Biodegradable Metal Vascular Stents
  • Biodegradable Metal Vascular Stents

Examples

Experimental program
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Effect test

Embodiment Construction

[0018] Firstly, the magnesium alloy of the present application is produced by conventional preparation methods in the field, and the specific composition is shown in Table 1.

[0019] Table 1 Composition list of magnesium alloys

[0020]

[0021] It can be seen that the yield strength and elongation of the magnesium alloy for vascular stents of the present application are both better than those of the WE43 alloy in the prior art. In addition, according to GB / T 16886.5-2003, the in vitro cell (L-929 fibroblast) toxicity test was carried out on the magnesium alloy of samples 1-4, and the results showed that the magnesium alloy degradation products of this application had no effect on cell activity, and the cytotoxicity was 0 grade, showing excellent biocompatibility. However, in Comparative Example 1, because the Sn content was too low, the Sn / Sc≥3 requirement of the present application was not met, and the cytotoxicity was grade 1.

[0022] Sample preparation: ① In vitro t...

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Abstract

The invention relates to a biodegradable vascular scaffold, which comprises: a tubular biodegradable metal structure, optionally a biodegradable metal layer covering at least one part of the surface of the metal structure, and optionally a compound layer covering at least one part of the surface of the metal structure and / or the metal layer, wherein the thickness of the metal layer is 0-20 [mu]m, preferably 5-15 [mu]m, and the thickness of the compound layer is 0-5 [mu]m, preferably 1-4 [mu]m.

Description

technical field [0001] The invention generally relates to a biodegradable metal stent, in particular to a blood vessel stent for a human body, and belongs to the technical field of medical materials. Background technique [0002] Vascular stents are used to treat occlusions in the lumen of blood vessels in animals. Vascular stents are generally tubular in shape and open at both longitudinal ends. The stent is placed into the body in a collapsed shape, usually into the lumen of a vessel, and then expanded to an expanded shape when at the treatment site. Vascular stents have become the treatment of choice for vascular disease, especially where the vascular disease occurs in the coronary arteries and peripheral vessels. [0003] Traditional vascular stents are constructed of alloys such as stainless steel, nickel-titanium, and cobalt-chromium, which are designed to maintain structural integrity throughout the life of the recipient. Biodegradable materials can have many advan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/14
CPCA61L31/022A61L31/088A61L31/148A61L2420/04
Inventor 柳光栋李中昕王衍根赵兴全
Owner 青岛市即墨区人民医院
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