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Bio-absorbable Mg-Zn-Ca three-elements magnesium alloy material

A biological, magnesium alloy technology, applied in the direction of prosthesis, medical science, etc., can solve the problems of neurotoxicity, non-Al element, undiscovered, etc., and achieve the effect of good biocompatibility and mechanical properties

Inactive Publication Date: 2006-06-28
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The magnesium alloys studied in the literature contain Al and rare earth elements. Although the biocompatibility of magnesium is good, the Al element is not an essential trace element for the human body. It is considered to have neurotoxicity and is a factor leading to Alzheimer's disease. The biocompatibility of rare earth elements is also controversial, and it is generally believed that the accumulation of rare earth elements in the body will manifest as toxic effects
However, the existing Mg-Zn and its Mg-Zn-Ca ternary magnesium alloy materials are all used in general industries, and so far no reports have been found on the application of Mg-Zn-based multi-element magnesium alloy materials to biomedical materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] A ternary Mg-Zn-Ca alloy material, wherein the weight percentage of Zn is 1%, and Ca is 0.1%. The purity of the raw material Mg is not less than 99.99%, the purity of Zn is greater than or equal to 99.999%, and the purity of Ca is greater than or equal to 99.75%. After smelting and casting with high cleanliness under the protection of argon, it can be made into required profiles for use after heat treatment and deformation processing. The material has good biocompatibility and mechanical properties, its tensile strength is 230MPa, plasticity is 12%, and it can be degraded and absorbed in biological fluid or blood environment.

Embodiment 2

[0012] A ternary Mg-Zn-Ca alloy material, wherein the weight percentage of Zn is 6%, and Ca is 0.5%. The purity of the raw material Mg is greater than or equal to 99.99%, the purity of Zn is greater than or equal to 99.999%, and the purity of Ca is greater than or equal to 99.75%. After smelting and casting with high cleanliness under the protection of argon, it can be made into required profiles for use after heat treatment and deformation processing. The material has good biocompatibility and mechanical properties, its tensile strength is 300MPa, plasticity is 8%, and it can be degraded and absorbed in biological fluid or blood environment.

Embodiment 3

[0014] A ternary Mg-Zn-Ca alloy material, wherein the weight percentage of Zn is 8%, and Ca is 2%. The purity of the raw material Mg is greater than or equal to 99.99%, the purity of Zn is greater than or equal to 99.999%, and the purity of Ca is greater than or equal to 99.75%. After smelting and casting with high cleanliness under the protection of argon, it can be made into required profiles for use after heat treatment and deformation processing. The material has good biocompatibility and mechanical properties, its tensile strength is 260MPa, plasticity is 2%, and it can be degraded and absorbed in biological fluid or blood environment.

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Abstract

A medical Mg-Zn-Ca alloy material absorbable in biologic body is proportionally prepared from high-purity full-nutritive Mg and Zn to form MgZn phase for high strength and anticorrosion nature, and Ca for fining grains for high strength and plasticity. It has high biocompatibility and mechanical performance and can be used for intravescular scaffold, bone nail, bone plate, etc.

Description

technical field [0001] The invention relates to a multi-component magnesium alloy in the field of biomedical materials, specifically, a Mg-Zn-Ca ternary magnesium alloy material that can be absorbed in a living body. Background technique [0002] Biodegradable absorbent materials in vivo are one of the important directions for the development of biomaterials. The currently researched and developed biodegradable absorbent materials in vivo are mainly polymer materials and certain ceramic materials, such as polylactic acid, polycaprolactone, calcium phosphate, etc. However, because the mechanical properties of polymer materials are generally low, the plasticity and toughness of ceramic materials are poor, and metal materials have good comprehensive mechanical properties, therefore, metal-based biodegradable absorbable materials have important medical application value. Magnesium is one of the most abundant elements on the earth. It is also the fourth most abundant cation in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04
Inventor 张小农
Owner SHANGHAI JIAO TONG UNIV
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