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Vitamin double-membrane liposome wrappage and preparation method thereof

A liposome and vitamin technology, applied in the field of skin care products, can solve the problems of accelerated melanin metabolism and excretion, vitamins are easily oxidized, accelerated skin metabolism, etc. Effect

Inactive Publication Date: 2019-09-17
广州维真渼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are VC whitening and freckle-removing products on the market, as well as VB 3 Whitening, but the actual effect of using these two ingredients alone is not ideal. Whitening and freckle removal must start from the following aspects at the same time: 1. Anti-oxidation, remove free radicals, and prevent free radicals from stimulating the skin. Too much melanin; 2. Do not release melanin. If the channel of melanin’s command is blocked, melanin cannot be released; 3. Accelerate the metabolism of melanin, and repair it in time to speed up skin metabolism
After many tests, the inventor found that the effect of using several vitamins with different functions at the same time is the best. However, simply mixing multiple vitamins can not achieve better actual results. The reason is that the vitamins used in skin care products are easily destroyed. Oxidation, poor stability, not easily absorbed by the skin

Method used

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  • Vitamin double-membrane liposome wrappage and preparation method thereof
  • Vitamin double-membrane liposome wrappage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Vitamin bilayer membrane liposome wrappings, including liposomes and active substances, the liposomes are multiple bilayer membrane structures, the liposomes include membrane bodies and a hydrophilic layer wrapped outside the membrane body, the membrane The body is natural soybean phospholipid, the hydrophilic layer is seaweed carrageenan, and the active substance includes hydrophilic vitamins wrapped in liposomes and lipophilic vitamins wrapped in liposome membranes.

[0026] In Example 1, hydrophilic vitamins include VB 12 , VC, VB 3 and VB 5 , the lipophilic vitamins include VF and VE.

[0027] In embodiment 1, the preparation method of vitamin bilayer membrane liposome wrapper comprises:

[0028] a. Spread natural soybean phospholipids with a purity of more than 96% on a fixed plane, and use microfluidic technology to supply seaweed carrageenan, so that seaweed carrageenan flows on the plane to wrap on soybean phospholipids to form a double-layer membrane lipid ...

Embodiment 2

[0031] In Example 2, the same parts as in Example 1 will not be described again, the difference is: the inventor combined the bilayer membrane liposome made in step a in Example 2 with deionized water at a temperature of 15°C Water is mixed according to the weight ratio of 1:1, and VB is added 12 , VC, VE, VB 3 and VB 5 , after ultrasonic dispersion for 7 minutes, the dispersion frequency is 25KHz, so that the hydrophilic vitamins are wrapped in the double-layer liposomes, and the lipophilic vitamins are wrapped in the suspension between the double-layer liposome membranes, so that the vitamin double Layer membrane liposome inclusions.

Embodiment 3

[0033] Vitamin bilayer membrane liposome wrappings, including liposomes and active substances, the liposomes are multiple bilayer membrane structures, the liposomes include membrane bodies and a hydrophilic layer wrapped outside the membrane body, the membrane The body is natural soybean phospholipid, the hydrophilic layer is seaweed carrageenan, and the active substance includes hydrophilic vitamins wrapped in liposomes and lipophilic vitamins wrapped in liposome membranes.

[0034] In Example 3, the hydrophilic vitamins include VB 12 , VC, VB 3 and VB 5 , the lipophilic vitamins include VF and VE.

[0035] In embodiment 3, the preparation method of vitamin bilayer membrane liposome wrapper comprises:

[0036] a. Spread natural soybean phospholipids evenly on a fixed plane, and use microfluidic technology to supply seaweed carrageenan, so that seaweed carrageenan flows on the plane to wrap on soybean phospholipids to form double-layer membrane liposomes;

[0037] b. Mix t...

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Abstract

The invention relates to the field of skin care products, in particular to a vitamin double-membrane liposome wrappage and a preparation method thereof. The vitamin double-membrane liposome wrappage comprises a liposome and an active substance, wherein the liposome adopts a multiple double-membrane structure; and the active substance comprises hydrophilic vitamins wrapped in the liposome and lipophilic vitamins wrapped between liposome membranes. The preparation method comprises the steps of uniformly spreading natural soybean phospholipid on a fixing plane, and supplying seaweed carrageenin through a micro-fluidic control technique so that the seaweed carrageenin flows on the plane to form the double-membrane liposome wrapped on the soybean phospholipid; and mixing the prepared double-membrane liposome with deionized water, adding VB12, VC, VE, VB3 and VB5, performing ultrasonic dispersion so that the hydrophilic vitamins are wrapped in the double-membrane liposome and the lipophilic vitamins are wrapped in suspension between the membranes of the double-membrane liposome, so as to obtain the vitamin double-membrane liposome wrappage. The vitamins after being wrapped through the double-membrane liposome are absorbed by skin, so that the biological availability is higher.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to a vitamin double membrane liposome wrap and a preparation method thereof. Background technique [0002] There are many reasons for the increase of melanin. Various reasons lead to the increase of free radicals, resulting in the increase of tyrosinase activity, which accelerates the oxidation of butyric acid into dopa, and under the action of tyrosinase, dopa is oxidized into dopaquinone to form dopa pigment. Basin produces melanin, and if melanin cannot be metabolized, the skin will turn black. If the melanin cannot be metabolized locally, spots will form. Diseases caused by melanin, such as freckles, chloasma, melanosis, etc., have become the subject of research in the beauty industry. [0003] There are VC whitening and freckle-removing products on the market, as well as VB 3 Whitening, but the actual effect of using these two ingredients alone is not ideal. Whitening and fre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/14A61K8/368A61K8/55A61K8/67A61Q19/02
CPCA61K8/14A61K8/368A61K8/553A61K8/67A61K8/673A61K8/675A61K8/678A61K8/73A61K2800/56A61K2800/592A61Q19/02
Inventor 靳惠民
Owner 广州维真渼生物科技有限公司
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