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Method for judging occurrence of Parkinson's diseases based on spontaneous fluorescence on fingernails and application thereof

A Parkinson's disease, autofluorescence technology, applied in the analysis, application, diagnosis and other directions using fluorescence emission, can solve the inconvenience of patients, non-invasive, fast and economical method for patients with Parkinson's disease, no non-invasive Parkinson's disease Methods of getting sick, etc.

Inactive Publication Date: 2019-10-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can only be tested by more expensive methods such as nuclear magnetic resonance in the hospital, which is very inconvenient for patients, takes a relatively long time and is expensive
So far, there is no non-invasive, fast, economical method that can be used at home to determine whether Parkinson's disease is present, and there is no non-invasive, fast, and economical method that can be used to screen out Parkinson's disease patients during physical examination

Method used

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  • Method for judging occurrence of Parkinson's diseases based on spontaneous fluorescence on fingernails and application thereof
  • Method for judging occurrence of Parkinson's diseases based on spontaneous fluorescence on fingernails and application thereof
  • Method for judging occurrence of Parkinson's diseases based on spontaneous fluorescence on fingernails and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: The excitation light is blue light band, the relationship between nail autofluorescence intensity and Parkinson's disease.

[0030] According to the present invention, for the nails of Parkinson's disease or high-risk groups, an instrument is used to perform real-time non-invasive imaging of nail autofluorescence. The experimental results show that compared with the autofluorescence intensity of each nail position in high-risk groups, the autofluorescence intensity of the corresponding positions of Parkinson's disease patients is significantly increased. ( figure 1 and figure 2 )

Embodiment 2

[0031] Example 2: The excitation light is in the blue light band, and the relationship between the difference in autofluorescence intensity at the left and right symmetrical positions of the subject's nails and Parkinson's disease.

[0032] According to the present invention, for Parkinson's disease or high-risk groups, the instrument is used to perform real-time non-invasive imaging of nail autofluorescence at symmetrical positions on the left and right sides. The experimental results show that the autofluorescence intensity of nails in high-risk groups is symmetrical, while the autofluorescence intensity of Parkinson's disease patients is asymmetrical. ( image 3 )

Embodiment 3

[0033] Example 3: The excitation light is in the blue light band, autofluorescence in various parts of the nail, and comparison between Parkinson's disease and cerebral apoplexy.

[0034] According to the present invention, for patients with Parkinson's disease or cerebral apoplexy, an instrument is used to perform real-time non-invasive imaging of nail autofluorescence. The experimental results showed that compared with the stroke population, the autofluorescence intensity of Parkinson's disease patients was significantly higher. However, the intensity difference between left and right symmetrical positions of autofluorescence is significantly reduced.

[0035] Based on the technology of the present invention, it will be applied (including but not limited to): 1. Parkinson's disease screening in population checkup. 2. Self-screening for Parkinson's disease at home. 3. Used in the diagnosis of Parkinson's disease in hospitals at all levels (including community hospitals and ...

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Abstract

The invention provides a method for judging the occurrence of Parkinson's diseases based on spontaneous fluorescence on fingernails and application thereof, and the application is the application ofa biomarker in preparing a product used for diagnosis of the parkinson's diseases. The biomarker uses excitation light of 400 nm to 750 nm to excite the spontaneous fluorescence intensity of the fingernails of a testee, and the wavelength range of the spontaneous fluorescence is between 420 nm and 800 nm. Based on the detection of the intensity and distribution of spontaneous fluorescence intensity of the fingernails, and the method for judging the occurrence of the Parkinson's diseases is noninvasive, efficient, simple, economical, high in accuracy and good in repeatability.

Description

technical field [0001] The invention relates to the intensity and left-right spatial distribution of nail autofluorescence as a method for judging the onset of Parkinson's disease. Specifically, it refers to judging whether the subject suffers from Parkinson's disease and the degree of onset of Parkinson's disease by comparing the nail autofluorescence intensity and the left and right fluorescence intensity distributions. Background technique [0002] Parkinson's disease (PD) is the most common movement disorder in the elderly and the second most common neurodegenerative disease. The main pathological features are the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain and the deposition of intracellular inclusion bodies - Lewy bodies. Clinically, the main manifestations are resting tremor, muscle rigidity and bradykinesia. [0003] In 2005, there were about 2 million cases of Parkinson's disease in China, and about 4.1 million cases worldwide. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/0071A61B5/4082
Inventor 殷卫海张铭超陶钺李雨嘉
Owner SHANGHAI JIAO TONG UNIV
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