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Phlegm eliminating drug solution preparation for inhalation and preparing method thereof

A solution and preparation technology, applied in the field of pharmaceutical preparations, can solve the problems of hidden safety hazards and the lack of standardized use methods in the instructions, and achieve the effects of less dosage, no toxic side effects, and increased compliance.

Inactive Publication Date: 2019-10-11
INCREASEPHARM HENGQIN INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, injections are often used for nebulization inhalation, but there is no standardized method of use in the instruction manual, which is beyond the scope of use, so there are potential safety hazards in use
The prior art also does not have the special preparation for the prescription atomization inhalation of Qutanling

Method used

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  • Phlegm eliminating drug solution preparation for inhalation and preparing method thereof
  • Phlegm eliminating drug solution preparation for inhalation and preparing method thereof
  • Phlegm eliminating drug solution preparation for inhalation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]

[0039] (1) Take 200ml of fresh bamboo leek, add 0.05% activated carbon, stir well, let stand for more than 24h, filter, and ultra-filter to obtain the active ingredients of fresh bamboo leek;

[0040] (2) Get 80 g of Houttuynia cordata, add 8 times the amount of water, carry out distillation, collect 100 ml of distillate, and obtain the active ingredient of Houttuynia cordata;

[0041] (3) Get the active ingredient of fresh bamboo leek and Houttuynia cordata active ingredient, merge, stir and make dissolving; Add hydrochloric acid to adjust pH value to 3.0, add isotonic agent, filter, potting, sterilize, promptly obtain the present invention solution.

Embodiment 2

[0043] Qutanling solution preparation for inhalation 1000ml

[0044]

[0045] (1) Get 300ml of fresh bamboo leek, add 0.05% activated carbon, stir well, let stand for more than 24h, filter, and ultra-filter to obtain the active ingredients of fresh bamboo leek;

[0046] (2) Get 120 g of Houttuynia cordata, add 9 times the amount of water, carry out distillation, collect 150 ml of distillate, and obtain the active ingredient of Houttuynia cordata;

[0047] (3) Take the active ingredients of fresh bamboo leek and Houttuynia cordata, combine them, add an appropriate amount of co-solvent polysorbate 80 and stir to make them completely dissolved; add acetic acid and sodium acetate buffer solution to adjust the pH value to 4.0, add isotonic agent , filtered, potted and sterilized to obtain the solution of the present invention.

Embodiment 3

[0049] Qutanling solution preparation for inhalation 1000ml

[0050]

[0051] (1) Get 400ml of fresh bamboo leek, add 0.05% activated carbon, stir well, let stand for more than 24h, filter, and ultra-filter to obtain the active ingredients of fresh bamboo leek;

[0052] (2) Get 150 g of Houttuynia cordata and add 10 times the amount of water, carry out distillation, collect 200 ml of distillate, and obtain the active ingredient of Houttuynia cordata;

[0053] (3) Take the active ingredients of fresh bamboo leek and Houttuynia cordata, combine them, add an appropriate amount of co-solvent polysorbate 80 and stir to dissolve completely; add an appropriate amount of citric acid and sodium citrate buffer solution, and adjust the pH value to 5.0 , adding an isotonic agent, filtering, potting, and sterilizing to obtain the solution of the present invention.

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Abstract

The invention relates to a phlegm eliminating drug solution preparation for inhalation and a preparing method thereof, and belongs to the field of the pharmaceutics technology. The phlegm eliminatingdrug solution preparation for inhalation comprises an effective component, an isotonic agent and a solvent, wherein the effective component comprises effective components extracted from bamboo juice and houttuynia cordata. The phlegm eliminating drug solution preparation for inhalation can rapidly form aerosol through an atomizer and can directly and rapidly act on an affected part and be rapidlyabsorbed to have an effect; the use dosage is small, the effect is rapidly realized, the treatment effect is good, and no other toxic or side effects exist.

Description

technical field [0001] The invention relates to a Qutanling solution preparation for inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Expectorant, also known as expectorant, is the use of expectorant drugs to eliminate or dissipate turbid phlegm, and treat various phlegm diseases. Phlegm is a pathological product produced by the body's water-fluid metabolism disorder and water-dampness accumulation, and it acts as the cause of various phlegm diseases. Phlegm can stay not only in the lungs, but also in other parts of the human body, so there are many diseases and syndromes caused by phlegm, and the method of eliminating phlegm is widely used. It is often used for cough, wheeze and expectoration caused by stagnant phlegm in the lungs; chest tightness, palpitations, dizziness and mania caused by turbid phlegm in the heart; nausea and vomiting, fullness and discomfort caused by phlegm stagnant in the stomach; scroful...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/12A61K9/08A61P11/10A61P11/00
CPCA61K9/0078A61K9/08A61K9/12A61K36/78A61K36/899A61K2300/00
Inventor 张保献胡杰王志华
Owner INCREASEPHARM HENGQIN INST CO LTD
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