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Inhibiting or alleviating agent for a beta-induced damage

A medicament, a technology for oxidative damage, applied in the field of Aβ-induced damage inhibition or alleviation medicaments, and can solve the problem that the antioxidative effect of nerve damage is not clear and the like

Inactive Publication Date: 2019-10-25
刘军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the potential antioxidant effect of NTP against nerve injury has not yet been clarified

Method used

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  • Inhibiting or alleviating agent for a beta-induced damage
  • Inhibiting or alleviating agent for a beta-induced damage
  • Inhibiting or alleviating agent for a beta-induced damage

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Experimental program
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Effect test

Embodiment

[0036] (1) Cell culture, differentiation, Aβ 25-35 preparation and handling

[0037] Methods for the culture and differentiation of HT22 cells have been described in detail previously (see Liu J, Li L and Suo WZ. HT22 hippocampal neuronal cell line possesses functional cholinergic properties. Life Sci 2009; 84:267-271; and Zhao ZY, Luan P , Huang SX et al.Edaravoneprotects HT22 neurons from H 2 o 2 -induced Apoptosis by Inhibiting the MAPK Signaling Pathway. CNS Neurosci Ther 2013; 19:163-169). Briefly, HT22 cells were cultured in DMEM medium supplemented with 10% FBS, 100 U / mL penicillin, and 100 ug / mL streptomycin, and differentiated in neural basal medium with N2 supplement for 24 h before treatment . Aβ 25-35 Pre-age the peptides by diluting in sterile saline at a concentration of 0.5 mM and maintaining at 37°C for 7 days. According to our previous studies (see Fan S, Zhang B, Luan P et al. PI3K / AKT / mTOR / p70S6K Pathway is involved in Aβ25-35-induced autophagy. Biomed...

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PUM

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Abstract

An inhibiting or alleviating agent for amyloid beta (A beta)-induced damage in hippocampus including an extract from inflamed tissues inoculated with vaccinia virus. And the use of the extract from inflamed tissues inoculated with vaccinia virus in the preparation of an agent for inhibiting or alleviating A beta-induced damage in hippocampus.

Description

technical field [0001] The present invention relates to an agent for suppressing or alleviating β-amyloid (Aβ)-induced damage in the hippocampus, which includes an extract from inflamed tissue inoculated with vaccinia virus (hereinafter, it may be referred to as "extract") . Background technique [0002] According to the 2016 World Alzheimer Report, the global population is aging rapidly due to increasing life expectancy. Globally, 47 million people are reported to be living with dementia, and this number is expected to increase to more than 131 million by 2050. In China, this number is expected to increase to over 16 million by 2030. It is clear that the dementia epidemic has a huge impact on people's quality of life and the economy. [0003] Alzheimer's disease (AD) is the most common progressive dementia among the elderly. So far, there are no effective antidementia drugs available for AD management due to its complex mechanism. Moreover, the discovery, development a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61P25/28
CPCG01N33/6872G01N33/5023A61K35/36A61K9/0019A61K9/0053A61P25/16A61P25/28
Inventor 刘军
Owner 刘军
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