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Bidirectional regulation of osteoblast and osteoclast response behavior coating and its construction method

A two-way regulation, osteoclast technology, applied in coatings, pharmaceutical formulations, medical science, etc., can solve the problems of osteogenesis and osteoclast response behavior regulation, affecting bone injury healing, single function, etc., to achieve easy promotion, structure Stable, not easy to fall off effect

Active Publication Date: 2021-02-02
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current surface modification methods have single functions, which can only satisfy the process of promoting osteogenesis or inhibiting osteoclastosis, and cannot effectively regulate the response behavior of osteogenesis and osteoclastosis, which will affect the healing of bone injuries and even regenerate bone. Structure

Method used

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  • Bidirectional regulation of osteoblast and osteoclast response behavior coating and its construction method
  • Bidirectional regulation of osteoblast and osteoclast response behavior coating and its construction method
  • Bidirectional regulation of osteoblast and osteoclast response behavior coating and its construction method

Examples

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Effect test

Embodiment 1

[0027] A method for constructing a coating that bidirectionally regulates the response behavior of osteoblasts and osteoclasts, comprising the following steps:

[0028] (1) Substrate pretreatment: Grind the magnesium metal sheet with silicon carbide sandpaper with a mesh number of 320#, 600#, 1200# and 2000# until there are no obvious scratches on the surface, and then add the polished metal sheet to Ultrasonic cleaning with alcohol for 1 minute, cleaning 3 times, and finally drying the cleaned metal sheet with ear cleaning balls, and putting it in a vacuum drying oven;

[0029] (2) Alkali activation treatment: put the metal sheet dried in step (1) into a sodium hydroxide solution with a concentration of 3mol / L, soak it for 24 hours at 60°C, then take out the metal sheet, and wash it with deionized water for 3 times, then blow dry and put it in a vacuum drying oven;

[0030] (3) Prepare a mixed solution of organic phosphonic acid: take a phytic acid solution with a concentrat...

Embodiment 2

[0033] A method for constructing a coating that bidirectionally regulates the response behavior of osteoblasts and osteoclasts, comprising the following steps:

[0034] (1) Substrate pretreatment: Grind the magnesium metal sheet with silicon carbide sandpaper with a mesh number of 320#, 600#, 1200# and 2000# until there are no obvious scratches on the surface, and then add the polished metal sheet to Ultrasonic cleaning with alcohol for 1 minute, cleaning 3 times, and finally drying the cleaned metal sheet with ear cleaning balls, and putting it in a vacuum drying oven;

[0035] (2) Alkali activation treatment: put the metal sheet dried in step (1) into a sodium hydroxide solution with a concentration of 2mol / L, soak it for 20 hours at 60°C, then take out the metal sheet, and wash it with deionized water for 3 times, then blow dry and put it in a vacuum drying oven;

[0036] (3) Prepare a mixed solution of organic phosphonic acid: take a phytic acid solution with a concentrat...

Embodiment 3

[0039] A method for constructing a coating that bidirectionally regulates the response behavior of osteoblasts and osteoclasts, comprising the following steps:

[0040] (1) Substrate pretreatment: Grind the magnesium metal sheet with silicon carbide sandpaper with a mesh number of 320#, 600#, 1200# and 2000# until there are no obvious scratches on the surface, and then add the polished metal sheet to Ultrasonic cleaning with alcohol for 1 minute, cleaning 3 times, and finally drying the cleaned metal sheet with ear cleaning balls, and putting it in a vacuum drying oven;

[0041] (2) Alkali activation treatment: put the metal sheet dried in step (1) into a sodium hydroxide solution with a concentration of 2 mol / L, soak it for 24 hours at 60°C, then take out the metal sheet and wash it with deionized water for 3 times, then blow dry and put it in a vacuum drying oven;

[0042] (3) Prepare a mixed solution of organic phosphonic acid: take a solution of hydroxyethylidene diphosph...

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Abstract

The invention provides a method for constructing a coating for bidirectional regulation of response behaviors of osteoblasts and osteoclasts, comprising the following steps: substrate pretreatment; alkali activation treatment; configuration of organic phosphonic acid mixed solution; and construction of a bidirectional regulation functional coating. It also includes a bidirectional regulation osteoblast and osteoclast response behavior coating prepared by the above construction method. The invention optimizes the content ratio of polyphosphonic acid and bisphosphonic acid molecules, and the used polyphosphonic acid molecules and bisphosphonic acid molecules are respectively helpful to promote osteogenesis and inhibit osteoclastosis, obtain high-quality coatings, and achieve multiple The release of an organic phosphonic acid can be controlled to realize the bidirectional regulation function.

Description

technical field [0001] The invention belongs to the technical field of cell response behavior coating components, and in particular relates to a bidirectional regulation osteoblast and osteoclast response behavior coating and a construction method thereof. Background technique [0002] Bone injury is the main cause that affects the quality of life of human beings, and the number of patients is on the rise with the influence of population aging. Currently, implant intervention is an effective means of treating bone injuries. However, the biofunctionalization of most implant surfaces is insufficient to promote bone remodeling at the damaged site, and the long healing period of bone damage will bring economic and psychological burdens to patients. Therefore, it is urgent to make the surface of bone implant materials have osteogenic function through surface modification. [0003] At present, the most widely used method of surface modification of implant materials is to carry b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/28A61L27/04A61L27/50A61L27/54
CPCA61L27/047A61L27/28A61L27/50A61L27/54A61L2300/21A61L2400/18A61L2420/02A61L2420/06A61L2430/02
Inventor 万国江唐帅张文泰钱军余莫小山鲜鹏黄楠
Owner SOUTHWEST JIAOTONG UNIV
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