Bone graft implant and preparation method thereof

An implant and bone transplantation technology, applied in the field of preparation of the bone transplantation implant, can solve the problems of high absorption rate of demineralized bone matrix, limited clinical application, easy deformation and collapse, etc. Effects of strength and degradation cycles

Active Publication Date: 2019-11-29
北京科健生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, demineralized bone matrix has a high absorption rate and is easy t...

Method used

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  • Bone graft implant and preparation method thereof
  • Bone graft implant and preparation method thereof
  • Bone graft implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of completely demineralized bone matrix and partially demineralized bone matrix: take cortical bone or cancellous cortical mixed bone from the diaphysis part of allograft bone extremity bone that is deep-frozen (stored at -80°C for more than 6 months), and remove all Attached soft tissue, central bone marrow and cartilage are mechanically cut into prefabricated shapes with CNC machining tools, and multiple rows of small holes are precisely drilled, then degreased in 30% hydrogen peroxide at 38°C for 72 hours, and the liquid is changed every 24 hours; injection Rinse with water, remove residual hydrogen peroxide in 75% ethanol for 24 hours, rinse with water for injection; chloroform:methanol ratio is 3:1, at room temperature, partially deproteinize in chloroform:methanol (3:1) solution 4 Hours, rinse with water for injection; decalcify in 0.6M hydrochloric acid for 12-48 hours to prepare partially demineralized bone matrix. The Ca content in DBM is between 5-...

Embodiment 2

[0039] DBM and glycosaminoglycan DHT cross-linking reaction, configure 0.1% hyaluronic acid solution, fully stir to dissolve, immerse DBM in the solution, shake and incubate at room temperature at 80-10rpm for 8 hours, remove water by freeze-drying method, and lose weight on drying method Determine that the residual moisture content is lower than 15%, then place it in a vacuum dryer to pre-evacuate to 100Pa, start heating and heating, when the temperature rises to a predetermined temperature of 100°C, start timing and maintain the reaction temperature for 8 hours, then take out the sample and irradiate at 25kGy Sterilize.

[0040]Further, multiple rows of small holes are prefabricated on the surface of the material for suturing and fixing the material during the operation. The schematic diagram of its structure is shown in figure 1 shown.

Embodiment 3

[0042] The only difference from Example 2 is: the temperature of the thermal crosslinking reaction is 120° C., and the reaction temperature is maintained for 8 hours.

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Abstract

The invention provides a bone graft implant and a preparation method thereof. A decalcified bone matrix is used as a basic material; collagen in the decalcified bone matrix is subjected to a thermal cross-linking reaction, and collagen in the decalcified bone matrix and glycosaminoglycan are subjected to a thermal cross-linking reaction so as to obtain a bone graft implant. According to the invention, mechanical strength and degradation period of the bone graft implant are enhanced, which promotes cartilage cell conversion. The product can be used as the bone graft implant to be applied to nasal plastic surgery and other surgeries, and can replace autologous cartilage tissues to be used for comprehensive rhinoplasty under the condition that a patient is unwilling to use the autologous cartilage tissues or the autologous cartilage tissues is not applicable.

Description

technical field [0001] The invention relates to a bone graft implant, in particular to a bone graft implant prepared with decalcified bone matrix as the basic material. The invention also relates to a preparation method of the bone graft implant. The bone graft implant of the present invention can be used for comprehensive shaping of the nose and other parts. Background technique [0002] Comprehensive rhinoplasty is one of the common plastic and cosmetic surgeries, that is, to improve the appearance of the nose by filling various autologous or allogeneic tissues or tissue substitutes to elevate the external nose. The quality of rhinoplasty materials is a key factor in determining the effect of surgery. Silicone and expanded polytetrafluoroethylene are the most commonly used materials for prosthetic rhinoplasty in clinical practice. However, in recent years, many scholars have pointed out the shortcomings and shortcomings of silicone prosthesis through clinical trials, suc...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/20A61L27/50A61L27/56A61L27/58
CPCA61L27/20A61L27/3608A61L27/50A61L27/56A61L27/58A61L2430/06
Inventor 李智峰盖增苟元彬李湘杰李次会
Owner 北京科健生物技术有限公司
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