Partitioning device for partitioned bone-tendon interface scaffolds

Abstract

The present application discloses a separation device and a method for partitioning bone-tendon interface brackets. The method includes the following steps: S1. Place several three-phase tissue slices on the bottom of the first cavity from top to bottom to form several Triphasic tissue scaffolds of scaffold layers. S2. Press the partition plate on the three-phase tissue sheet, and form a bone partition area, a cartilage partition area, and a tendon partition area in the first cavity through the partition board, wherein the bone partition area, the cartilage partition area, and the tendon partition area are the same as the three The bone area, cartilage area and tendon area of ​​the phase tissue scaffold are matched. S3. Add bone growth factor liquid to the bone partition area, add cartilage growth factor liquid to the cartilage partition area, and add tendon growth factor liquid to the tendon area. The three-phase tissue sheet prepared by the above method has bionic properties, and has a relatively normal tissue type instead of a simple flat structure, which is more in line with the physiological structure of the human body.

Description

technical field [0001] The invention mainly relates to the defect repairing technology of the joint of bone and tendon, and in particular relates to a separation device and a separation method for partitioning the bone-tendon interface support. Background technique [0002] The following content is only the inventor's knowledge of the relevant technical field, and does not necessarily constitute prior art. [0003] The emergence and vigorous development of tissue engineering technology has encouraged clinicians and researchers to try to solve this problem through tissue engineering strategies. The traditional bone-tendon interface regeneration strategy of tissue engineering has the following problems: 1) Existing scaffolds are only biomimetic designed from one or two aspects of morphological structure, gradient mineralization, and mechanical properties, and lack multiple biomimetic properties; 2) Existing scaffolds Most of them are made of artificial synthetic materials, an...

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Problems solved by technology

The traditional bone-tendon interface regeneration strategy of tissue engineering has the following problems: 1) Existing scaffolds are only biomimetic designed from one or two aspects of morphological structure, gradient mineralization, and mechanical properties, and lack multiple biomimetic properties; 2) Existing scaffolds Most of them are made of artificial synthetic materials, and lack the characteristics of stem cell-directed differentiation induction in different areas of bone, fibrocartilage and tendon of the scaffold; 3) The introduction of exogenous seed cells has the risk of tumorigenesis, and the seed cells are loaded on the scaffold in vitro, The operation process of constructing tissue engineered grafts is cumbersome and difficult to preserve

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