Bionic three-phase tissue engineering scaffold

Abstract

The application discloses a bionic three-phase tissue engineering scaffold comprising a plurality of scaffold layers that are laminated longitudinally. The scaffold layers are composed of bone scaffolds, cartilage scaffolds and tendon scaffolds which are sequentially distributed in a transverse direction; the at least parts of the bone scaffolds of the adjacent layers are abutted against each other; at least parts of the cartilage scaffolds of the adjacent layers are abutted against each other; at least parts of the tendon scaffolds of the adjacent layers are abutted against each other; and the positions and / or proportions of the areas occupied by the bone scaffolds, the cartilage scaffolds and the tendon scaffolds in the at least two scaffold layers are different. According to the invention, the engineering scaffold obtained by lamination of all scaffold layers can have the bionic characteristic by controlling the positions and / or proportions of the areas occupied by the bone scaffolds, the cartilage scaffolds and the tendon scaffolds in all scaffold layers; and construction is performed based on the positions and / or proportions of the bone scaffold, the cartilage scaffold and thetendon scaffold in an actual tissue so as to form a normal tissue form instead of a simple flush structure, so that the engineering scaffold conforms to the physiological structure of a human body.

Description

technical field [0001] The invention mainly relates to the defect repair technology of the joint of bone and tendon, and in particular relates to a bionic three-phase tissue engineering scaffold and a construction method thereof. Background technique [0002] The following content is only the inventor's knowledge of the relevant technical field, and does not necessarily constitute prior art. [0003] The emergence and vigorous development of tissue engineering technology has encouraged clinicians and researchers to try to solve this problem through tissue engineering strategies. The traditional bone-tendon interface regeneration strategy of tissue engineering has the following problems: 1) Existing scaffolds are only biomimetic designed from one or two aspects of morphological structure, gradient mineralization, and mechanical properties, and lack multiple biomimetic properties; 2) Existing scaffolds Most of them are made of artificial synthetic materials, and lack the char...

AI Technical Summary

Problems solved by technology

The traditional bone-tendon interface regeneration strategy of tissue engineering has the following problems: 1) Existing scaffolds are only biomimetic designed from one or two aspects of morphological structure, gradient mineralization, and mechanical properties, and lack multiple biomimetic properties; 2) Existing scaffolds Most of them are made of artificial synthetic materials, and lack the characteristics of stem cell-directed differentiation induction in different areas of bone, fibrocartilage and tendon of the scaffold; 3) The introduction of exogenous seed cells has the risk of tumorigenesis, and the seed cells are loaded on the scaffold in vitro, The operation process of constructing tissue engineered grafts is cumbersome and difficult to preserve

However, the existing tissue engineering scaffolds do not consider how to simulate the normal bone-cartilage-tendon three-phase structure of the bone-tendon interface, resulting in the lack of dual bionic properties of normal tissue morphology and tensile mechanical properties of the existing scaffolds

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